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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0995667 (2016-01-14) |
등록번호 | US-9649093 (2017-05-16) |
발명자 / 주소 |
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출원인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 386 |
A mass includes particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns. The mass exhibi
A mass includes particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns. The mass exhibits enhanced detectability by ultrasound energy during the lifetime; the lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward; and a zero or non-zero fluid-to-solid ratio.
1. A mass comprising: particles that exhibit an in vivo lifetime and that include a bioresorbable materialandbubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns;the mass exh
1. A mass comprising: particles that exhibit an in vivo lifetime and that include a bioresorbable materialandbubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns;the mass exhibits enhanced detectability by ultrasound energy during the lifetime;andthe lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward. 2. The mass of claim 1 wherein the lifetime ends between about 6 and about 12 weeks afterward. 3. The mass of claim 2 wherein all of the length, width, and height dimensions are less than or equal to about 2000 microns. 4. The mass of claim 3 wherein all of the length, width, and height dimensions are between about 10 and about 500 microns. 5. The mass of claim 4 wherein all of the length, width, and height dimensions are between about 20 and about 200 microns. 6. The mass of claim 3 having a volume between about 0.2 and about 1.2 ml. 7. The mass of claim 6 having a volume of about 0.5 ml. 8. The mass of claim 6 wherein the bioresorbable material comprises a bioresorbable polymeric material. 9. The mass of claim 8 wherein the bioresorbable polymeric material comprises polymers, copolymers, polymer alloys, polymer mixtures, or other combinations of poly(esters), poly(hydroxy acids), poly(lactones), poly(amides), poly(ester-amides), poly(amino acids), poly(anhydrides), poly(orthoesters), poly(carbonates), poly(phosphazines), poly(thioesters), poly(urethanes), poly(ester urethanes), polysaccharides, polylactic acids, polyglycolic acids, polycaproic acids, polybutyric acids, or polyvaleric acids. 10. The mass of claim 9 wherein the bioresorbable polymeric material: comprises polymers, copolymers, polymer alloys, polymer mixtures, or other combinations of polyglycolic acids, polylactic acids, and polycaproic acidsandhas an average molecular weight of less than about 60 kD. 11. The mass of claim 10 wherein the bioresorbable material comprises about 65% by weight polylactic acid and about 35% by weight polyglycolic acid. 12. The mass of claim 8 further comprising less than or equal to 10% by weight of a blowing agent. 13. The mass of claim 12 further comprising less than or equal to 5% by weight of a blowing agent. 14. The mass of claim 13 further comprising less than or equal to 2% by weight of a blowing agent. 15. The mass of claim 14 wherein the blowing agent comprises any one or any combination of sodium bicarbonate, ammonium carbonate, sodium boron hydride, silicon oxy-hydride, hydrochlorofluorocarbon compounds, chlorofluorocarbon compounds, mixtures of sodium bicarbonate, ammonium carbonate, sodium boron hydride, silicon oxy-hydride, hydrochlorofluorocarbon compounds, and chlorofluorocarbon compounds, hexane, heptane, heptene, propyl alcohol, or isopropyl alcohol. 16. The mass of claim 15 wherein the blowing agent comprises sodium bicarbonate. 17. The mass of claim 12 further comprising a binding agent. 18. The mass of claim 17 wherein the binding agent comprises gelatin, polyethylene glycol, polyvinyl alcohol, glycerin, acrylic hydrogels, organic hydrogels, or their combinations. 19. The mass of claim 17 comprises gelatin in a weight proportion of about 1 part gelatin to between about 2 parts polymeric material to about 5 parts polymeric material. 20. The mass of claim 19 wherein the weight proportion of about 1 part gelatin to between about 1 part polymeric material to about 3 parts polymeric material. 21. The mass of claim 20 wherein gelatin comprises bovine collagen, porcine collagen, ovine collagen, equine collagen, synthetic collagen, agar, synthetic gelatin, or their combinations. 22. The mass of claim 19 further comprising a magnetic resonance imaging (MRI) agent, a colorant, a radioactive material, or a radiopaque material. 23. The mass of claim 22 comprising a radiopaque marker formed in a recognizable shape not naturally found within a patient's body. 24. The mass of claim 22 further comprising a biocompatible liquid. 25. The mass of claim 24 wherein the biocompatible liquid comprises any one or any combination of sterile saline, sterile saline containing an pharmaceutical agent, sterile saline containing an anesthetic agent, sterile saline containing a hemostatic agent, sterile saline containing a colorant, sterile saline containing a radio contrast agent, sterile saline containing an osmotic agent, sterile sugar solution, sterile sugar solution containing a pharmaceutical agent, sterile sugar solution containing an anesthetic agent, sterile sugar solution containing a hemostatic agent, sterile sugar solution containing a colorant, sterile sugar solution containing a radio contrast agent, biocompatible oils, biocompatible oils containing an pharmaceutical agent, biocompatible oils containing an anesthetic agent, biocompatible oils containing a hemostatic agent, biocompatible oils containing a colorant, biocompatible oils containing a radio contrast agent, adrenochrome, algin, alginic acid, aminocaproic acid, batroxobin, carbazochrome salicylate, cephalins, cotarmine, ellagic acid, epinephrine, ethamsylate, factor VIII, factor IX, factor XIII, fibrin, fibrinogen, naphthoquinone, oxamarin, oxidized cellulose, styptic collodion, sulamrin, thrombin, thromboplastin (factor III), tolonium chloride, tranexamic acid, or vasopression. 26. The mass of claim 25 wherein said biocompatible liquid comprises a pharmaceutical agent selected from the group consisting of penicillins, cephalosporins, vancomycins, aminoglycosides, quinolones, polymyxins, erythromycins, tetracyclines, streptomycins, sulfa drugs, chloramphenicols, clindamycins, lincomycins, sulfonamides, paclitaxel, docetaxel, acetyl sulfisoxazole, alkylating agents, antimetabolites, plant alkaloids, mechlorethamine, chlorambucil, cyclophosphamide, melphalan, ifosfamide, methotrexate, 6-mercaptopurine, 5-fluorouracil, cytarabine, vinblastine, vincristine, etoposide, doxorubicin, daunomycin, bleomycin, mitomycin, carmustine, lomustine, cisplatin, interferon, asparaginase, tamoxifen, flutamide, amantadines, rimantadines, ribavirins, idoxuridines, vidarabines, trifluridines, acyclovirs, ganciclovirs, zidovudines, foscarnets, interferons, prochlorperzine edisylate, ferrous sulfate, aminocaproic acid, mecamylamine hydrochloride, procainamide hydrochloride, isoproterenol sulfate, phenmetrazine hydrochloride, bethanechol chloride, methacholine chloride, isopropamide iodide, tridihexethyl chloride, phenformin hydrochloride, methylphenidate hydrochloride, theophylline cholinate, cephalexin hydrochloride, diphenidol, meclizine hydrochloride, prochlorperazine maleate, phenoxybenzamine, thiethylperzine maleate, anisindone, diphenadione erythrityl tetranitrate, isoflurophate, acetazolamide, methazolamide, bendroflumethiazide, chloropromaide, tolazamide, chlormadinone acetate, phenaglycodol, allopurinol, aluminum aspirin, hydrocortisone, hydrocorticosterone acetate, cortisone acetate, dexamethasone and its derivatives such as betamethasone, triamcinolone, methyltestosterone, 17-S-estradiol, ethinyl estradiol, ethinyl estradiol 3-methyl ether, prednisolone, 17-hydroxyprogesterone acetate compounds, 19-nor-progesterone, norgestrel, norethindrone, norethisterone, norethiederone, progesterone, norgesterone, norethynodrel, aspirin, indomethacin, naproxen, fenoprofen, sulindac, indoprofen, nitroglycerin, isosorbide dinitrate, propranolol, timolol, atenolol, alprenolol, cimetidine, clonidine, imipramine, dihydroxyphenylalanine, theophylline, calcium gluconate, ketoprofen, ibuprofen, cephalexin, haloperidol, zomepirac, ferrous lactate, vincamine, diazepam, phenoxybenzamine, milrinone, capropril, mandol, quanbenz, hydrochlorothiazide, ranitidine, flurbiprofen, fenufen, fluprofen, tolmetin, alclofenac, mefenamic, flufenamic, difuinal, nizatidine, sucralfate, etintidine, tetratolol, minoxidil, chlordiazepoxide, diazepam, amitriptyline, imipramine, prostaglandins, coagulation factors, adrenochrome, algin, alginic acid, aminocaproic acid, batroxobin, carbazochrome salicylate, cephalins, cotarmine, ellagic acid, epinephrine, ethamsylate, factor VIII, factor IX, factor XIII, fibrin, fibrinogen, naphthoquinone, oxamarin, oxidized cellulose, styptic collodion, sulamrin, thrombin, thromboplastin (factor III), tolonium chloride, tranexamic acid, or vasopression or analogs of these compounds, derivatives of these compounds, or pharmaceutically acceptable salts of these compounds, analogs, or derivatives. 27. The mass of claim 24 wherein said bio-resorbable material is effective to form a gel upon introduction within the body of an animal.
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