Adhesive-containing wound closure device and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-017/08
A61F-013/02
A61B-017/00
출원번호
US-0207984
(2008-09-10)
등록번호
US-9655622
(2017-05-23)
발명자
/ 주소
Jonn, Jerry
Hoskin, Glenn
Quintero, Julian
출원인 / 주소
Ethicon, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
80
초록
A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.
대표청구항▼
1. A method of bonding tissue, comprising: placing a single strip of flexible material over a section of tissue, wherein said flexible material comprises a polymerization initiator or rate modifier disposed in or on said flexible material, and an adhesive substance disposed on at least a portion of
1. A method of bonding tissue, comprising: placing a single strip of flexible material over a section of tissue, wherein said flexible material comprises a polymerization initiator or rate modifier disposed in or on said flexible material, and an adhesive substance disposed on at least a portion of a bottom side of said flexible material;applying a polymerizable adhesive composition over and fully covering a top surface of the single strip of flexible material; andallowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said tissue. 2. The method of claim 1, wherein the flexible material is a mesh. 3. The method of claim 2, wherein the mesh is formed of either woven or non-woven fabrics or materials. 4. The method of claim 1, wherein the polymerization initiator or rate modifier is selected from the group consisting of detergent compositions, nonionic surfactants, cationic surfactants, anionic surfactants, stannous octoate (tin (II) 2-ethylhexanoate), sodium tetradecyl sulfate, amphoteric or zwitterionic surfactants, amines, imines, amides, phosphines, phosphates, phosphonium salts, alcohols, methyl gallate, ascorbic acid, tannins, tannic acid, inorganic bases and salts, sulfur compounds, polymeric cyclic ethers, cyclic and acyclic carbonates, phase transfer catalysts, organometallics, manganese acetylacetonate, radical initiators and radicals, and bioactive compounds or agents. 5. The method of claim 4, wherein the polymerization initiator is one or more quaternary ammonium halide. 6. The method of claim 5, wherein the polymerization initiator is one or more alkylbenzyldimethylammonium chloride having an alkyl ranging from 6-18 carbon atoms. 7. The method of claim 5, wherein the polymerizable adhesive composition is a monomeric composition. 8. The method of claim 7, wherein polymerizable adhesive composition comprises one or more 1,1-disubstituted ethylene monomers. 9. The method of claim 8, wherein polymerizable adhesive composition comprises one or more monomer selected from the group consisting of methyl cyanoacrylate, ethyl cyanoacrylate, n-butyl cyanoacrylate, 2-octyl cyanoacrylate, methoxyethyl cyanoacrylate, ethoxyethyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, hexyl cyanoacrylate, butyl lactoyl cyanoacrylate, butyl glycolcyl cyanoacrylate, ethyl lactoyl cyanoacrylate, and ethyl glycoloyl cyanoacrylate. 10. The method of claim 1, wherein the adhesive substance is a pressure sensitive adhesive. 11. The method of claim 1, wherein the polymerizable adhesive composition is a monomeric composition. 12. The method of claim 11, wherein polymerizable adhesive composition comprises one or more 1,1-disubstituted ethylene monomers. 13. The method of claim 12, wherein polymerizable adhesive composition comprises one or more monomer selected from the group consisting of methyl cyanoacrylate, ethyl cyanoacrylate, n-butyl cyanoacrylate, 2-octyl cyanoacrylate, methoxyethyl cyanoacrylate, ethoxyethyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, hexyl cyanoacrylate, butyl lactoyl cyanoacrylate, butyl glycolcyl cyanoacrylate, ethyl lactoyl cyanoacrylate, and ethyl glycoloyl cyanoacrylate. 14. The method of claim 1, wherein the flexible material is a polypropylene mesh, the polymerization initiator is benzalkonium chloride, the adhesive substance is a pressure sensitive adhesive, and the polymerizable adhesive composition comprises 2-octyl cyanoacrylate monomer. 15. A method of bonding tissue, comprising: placing a single strip of biodegradable flexible material over a section of tissue, wherein said flexible material comprises a polymerization initiator or rate modifier disposed in or on said flexible material;applying a polymerizable adhesive composition comprising at least one alkyl ester cyanoacrylate monomer over and fully covering a top surface of the single strip of biodegradable flexible material; andallowing the polymerizable adhesive composition to permeate into and under the biodegradable flexible material and polymerize to form a composite structure bonded to said tissue. 16. The method of claim 1 or 15 wherein the flexible material is elastic. 17. The method of claim 1 or 15 wherein the flexible material is memory retentive. 18. The method of claim 1 or 15 wherein the flexible material is placed over the longitudinal axis of the tissue to be bonded. 19. The method of claim 18 wherein the step of applying the polymerizable adhesive composition over and fully covering a top surface of the single strip of flexible materials includes extending the application of the polymerizable adhesive composition over and beyond the edges of the flexible material.
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이 특허에 인용된 특허 (80)
Narang Upvan ; Nicholson William S. C., 1,1-disubstituted ethylene adhesive compositions containing polydimethylsiloxane.
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