초록

A separator disk for use in centrifugal separation of components is designed to automatically position itself during separation at the interface between the supernatant and the remaining components. Preferably the interface is between plasma and red blood cells.

대표청구항 ▼

1. A system comprising: a container;a physiological fluid subjected to centrifugation in the container so as to provide an interface in the physiological fluid with red blood cells separated from at least one desired component of the physiological fluid; anda floating separator structure floating wi

1. A system comprising: a container;a physiological fluid subjected to centrifugation in the container so as to provide an interface in the physiological fluid with red blood cells separated from at least one desired component of the physiological fluid; anda floating separator structure floating within the physiological fluid within the container, the floating separator structure having a shape and material that define a center of buoyancy of the floating separator structure in the physiological fluid within the container;wherein the floating separator structure includes: an outer periphery having an outer diameter smaller than an interior diameter of the container and having an axial height, an upwardly facing concave accumulating surface recessed lower than the axial height of the outer periphery and positioned radially inward from the outer periphery, and the center of buoyancy of the floating separator structure is located relative to the upwardly facing concave accumulating surface such that the upwardly facing concave accumulating surface is located just below the interface with the separated red blood cells to accumulate a small layer of red blood cells thereon while the outer periphery extends above the interface with the separated red blood cells. 2. The system according to claim 1, wherein the red blood cells reduce the surface tension between the at least one desired component and the accumulating surface, thereby facilitating release of the desired component from the accumulating surface. 3. The system according to claim 1, wherein the separator structure fits into the container such that a gap is formed between the outer periphery of the separator structure and the interior diameter of the container, the gap being of such a dimension that the red blood cells below said separator structure after separation do not flow appreciably through the gap at about 1G. 4. The system according to claim 1, wherein the accumulating surface of the separator structure is curved. 5. The system according to claim 1, wherein the accumulating surface of the separator structure is angled relative to a horizontal cross section of the container. 6. The system according to claim 1 wherein the separator structure is shaped such that its center of buoyancy is located above the accumulating surface of the separator structure. 7. The system according to claim 1, further comprising an elongated central portion extending from the upwardly facing concave accumulating surface of the separator structure. 8. The system of claim 7, wherein the elongated central portion has an axial height greater than the axial height of the outer periphery of the separator structure. 9. The system of claim 7, wherein the elongated central portion is joined with the upwardly facing concave accumulating surface of the separator structure, and the center of buoyancy of the floating separator structure is at least partially defined by the outer periphery, the elongated central portion, and the material of the floating separator structure.