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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0161134 (2014-01-22) |
등록번호 | US-9662298 (2017-05-30) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 11 인용 특허 : 582 |
Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are subs
Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
1. A foamable composition for a pharmaceutical comprising: A. a carrier comprising: a. at least about 20% by weight of a liquid wax comprising one or more free fatty acids, wherein at least one free fatty acid is oleic acid and wherein the oleic acid is at least about 20% by weight of the carrier;b.
1. A foamable composition for a pharmaceutical comprising: A. a carrier comprising: a. at least about 20% by weight of a liquid wax comprising one or more free fatty acids, wherein at least one free fatty acid is oleic acid and wherein the oleic acid is at least about 20% by weight of the carrier;b. a surface-active agent;c. a polymeric agent; andd. a solid wax comprising a solid paraffin wax;wherein the ratio of liquid wax to solid wax is about 3:1 to about 10:1, andB. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable composition;wherein the composition has a water content less than about 5% by weight;wherein the composition is not an emulsion; andwherein, upon release from a pressurized container, a breakable foam is produced. 2. The foamable composition of claim 1, wherein the solid wax further comprises a solid wax selected from the group consisting of a fatty acid, a fatty alcohol, a microcrystalline wax, a petroleum wax, a polyethylene wax, a beeswax, a candelilla wax, a castor wax, a Chinese wax, a Fischer-Tropsch wax, a rice bran wax, a tallow, a wool wax, and a mixture of any two or more thereof. 3. The foamable composition of claim 2, wherein the solid wax further comprises a solid wax selected from the group consisting of stearic acid, cetyl alcohol, behenyl alcohol, stearyl alcohol, and a mixture of any two or more thereof. 4. The foamable composition of claim 1, wherein the liquid wax enables the solid wax to solubilize. 5. The foamable composition of claim 1, wherein solid wax crystals are not visible and the composition is flowable through an aerosol valve. 6. The foamable composition of claim 1, wherein the polymeric agent is present in the composition at a concentration of about 0.01% to about 5% by weight of the carrier and is selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent, and a phase change agent. 7. The foamable composition of claim 1, wherein the surface-active agent is selected from the group consisting of a polysorbate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, a polyoxyethylene fatty acid ester, polyoxyethylene (8) stearate, polyoxyethylene (20) stearate, polyoxyethylene (40) stearate, polyoxyethylene (100) stearate, a polyoxyethylene alkyl ether, a polyoxyethylene cetyl ether, polyoxyethylene (23) cetyl ether, polyoxyethylene (2) cetyl ether, polyoxyethylene (10) cetyl ether, a sucrose ester, a partial ester of sorbitol, sorbitan monolaurate, a monoglyceride, a diglyceride, isoceteth-20, steareth 2, glyceryl stearate, steareth-21, sorbitan stearate, laureth 4, sorbitan monooleate, ceteareth 20, steareth 20, ceteth 20, macrogol cetostearyl ether, PEG-30 dipolyhydroxystearate, sucrose distearate, cetomacrogol ether, cetearyl glucoside, polysorbate 20; methyl glucose sesquistearate, a sucrose stearic acid ester, a phospholipid, and a mixture of any two or more thereof. 8. The foamable composition of claim 7, wherein the surface-active agent is selected from the group consisting of sorbitan stearate, glyceryl monostearate, and a mixture thereof. 9. The foamable composition of claim 1, wherein the surface active agent also functions as a solvent. 10. The foamable composition of claim 1, wherein the polymeric agent is selected from the group consisting of a cross-linked polyacrylate polymer, acrylates/C10-30 alkyl acrylate crosspolymers, a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenin gum, a xanthan gum, a quince seed extract, a tragacanth gum, a guar gum, a cationic guar, a hydroxypropyl guar gum, a starch, an amine-bearing polymer, a chitosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, a methylhydroxyethylcellulose, a carboxymethylcellulose, a hydroxyethylcarboxymethylcellulose, a cationic cellulose, an aluminum starch octenylsuccinate, a sodium starch octenylsuccinate, and a mixture of any two or more thereof. 11. The foamable composition of claim 1, wherein the composition further comprises a solvent selected from the group consisting of an organic carrier, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and a mixture thereof. 12. The foamable composition of claim 11, wherein the solvent comprises dimethyl sulfoxide. 13. The foamable composition of claim 11, wherein the solvent comprises a polyethylene glycol. 14. The foamable composition of claim 1, wherein the surface active agent is between about 0.2% to about 8% by weight. 15. The foamable composition of claim 1, further comprising an additional component selected from the group consisting of a modulating agent, a polar solvent, an anti perspirant, an anti-static agent, a buffering agent, a bulking agent, a chelating agent, a colorant, a conditioner, a deodorant, a diluent, a dye, an emollient, fragrance, a humectant, an occlusive agent, a penetration enhancer, a perfuming agent, a permeation enhancer, a pH-adjusting agent, a preservative, a skin penetration enhancer, a sunscreen, a sun blocking agent, a sunless tanning agent, a vitamin, and a mixture of any two or more thereof. 16. The foamable composition of claim 1, further comprising an active agent. 17. The foamable composition of claim 16, wherein at least 95% of the active ingredient has been solubilized. 18. The foamable composition of claim 16, wherein the active agent is selected from the group consisting of an active herbal extract, an acaricide, an age spot and keratose removing agent, an allergen, an analgesic, a local anesthetic, an antiacne agent, an antiallergic agent, an antiaging agent, an antibacterial, an antibiotic, an antiburn agent, an anticancer agent, an antidandruff agent, an antidepressant, an antidermatitis agent, an antiedemic, an antihistamine, an antihelminth, an antihyperkeratolyte agent, an antiinflammatory agent, an antiirritant, an antilipemic, an antimicrobial, an antimycotic, an antiproliferative agent, an antioxidant, an anti-wrinkle agent, an antipruritic, an antipsoriatic agent, an antirosacea agent, an antiseborrheic agent, an antiseptic agent, an antiswelling agent, an antiviral agent, an antiyeast agent, an astringent, a topical cardiovascular agent, a chemotherapeutic agent, a corticosteroid, a dicarboxylic acid, a disinfectant, a fungicide, a hair growth regulator, a hormone, a hydroxy acid, an immunosuppressant, an immunoregulating agent, an immunomodulatory, an insecticide, an insect repellent, a keratolytic agent, a lactam, a metal oxide, a mitocide, a neuropeptide, a steroid, a non-steroidal anti-inflammatory agent, an oxidizing agent, a pediculicide, a photodynamic therapy agent, a retinoid, a sanative, a scabicide, a vasoconstrictor, a vasodilator, a vitamin, a vitamin D derivative, a wound healing agent, a wart remover; an agent having activity against superficial basal cell carcinomas, actinic keratoses, Bowen's disease, or other squamous cell carcinomas and molluscum contagiosum; an agent having activity against herpes simplex virus infections, other viral infections, or eczema; a vaccine adjuvant, and a mixture of any two or more thereof. 19. The foamable composition of claim 18, wherein the active agent is an anti-cancer agent. 20. A method of treating or ameliorating a skin, mucosal or body cavity cancer disorder of a mammalian subject, comprising administering the foamable composition of claim 19 to the skin, a mucosal surface, or a body cavity of said mammalian subject. 21. The method of claim 20, wherein the cancer disorder is selected from the group consisting of skin neoplasia, skin neoplasms, skin cancer, ischemic necrosis, moles, Kaposi's sarcoma, melanoma, basal cell carcinoma, squamous cell carcinoma, scleroderma, vulvar intraepithelial neoplasia, genital cancer, cancer of the cervix, cancer of the vulva, cancer of the vagina, anal cancer, polyps of the colon and rectum, superficial basal cell carcinomas, and Bowen's disease. 22. A foamable composition for a pharmaceutical comprising: A. a carrier comprising: a. a solvent comprising: i. at least about 20% by weight of a liquid wax comprising one or more free fatty acids, wherein at least one free fatty acid is oleic acid and wherein the oleic acid is at least about 20% by weight of the carrier; andii. at least one potent solvent, wherein the concentration of the potent solvent is more than about 60% by weight of the solvent;b. a surface-active agent;c. a polymeric agent; andd. a solid wax comprising a solid paraffin wax;wherein the ratio of liquid wax to solid wax is about 3:1 to about 10:1, andB. a liquefied hydrocarbon gas propellant at a concentration of about 3% to about 35% by weight of the foamable composition;wherein,the foamable composition a water content less than about 5% by weight;wherein the foamable composition is not an emulsion; andupon release from a pressurized container, a breakable foam is produced. 23. The foamable composition of claim 1, wherein the solid wax comprises a paraffin wax, stearyl alcohol, behenyl alcohol, or a mixture of any two or more thereof; wherein the surface-active agent comprises glyceryl monostearate, sorbitan monostearate, or a mixture thereof; wherein the polymeric agent comprises a methylcellulose; wherein the composition further comprises a polar solvent comprising dimethyl sulfoxide, polyethylene glycol, or a mixture thereof; and wherein the composition further comprises an anti-cancer agent. 24. The foamable composition of claim 1, wherein the surface active agent is between about 0.2% to about 8% by weight; wherein the polymeric agent is present in the composition at a concentration of about 0.01% to about 5% by weight, and wherein the composition further comprises a polar solvent at a concentration of about 40% to about 80% by weight. 25. The foamable composition of claim 22, wherein the solid wax further comprises stearyl alcohol, behenyl alcohol, or a mixture thereof; wherein the surface-active agent comprises glyceryl monostearate, sorbitan monostearate, or a mixture thereof; wherein the polymeric agent comprises a methylcellulose; wherein the potent solvent comprises dimethyl sulfoxide, polyethylene glycol, or a mixture thereof; and wherein the composition further comprises an anti-cancer agent. 26. The foamable composition of claim 22, wherein the surface active agent is between about 0.2% to about 8% by weight; wherein the polymeric agent is present in the composition at a concentration of about 0.01% to about 5% by weight. 27. The foamable composition of claim 22, wherein the composition is waterless. 28. The foamable composition of claim 1, wherein the composition has a water content of less than about 2%. 29. The foamable composition of claim 1, wherein the composition has a water content of less than about 1.5%. 30. The foamable composition of claim 22, wherein the composition has a water content of less than about 2%. 31. The foamable composition of claim 22, wherein the composition has a water content of less than about 1.5%.
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