A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/p
A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/plasma insulin concentration.
대표청구항▼
1. A method of increasing carnitine retention in human and/or animal skeletal muscle of a subject, the method comprising orally administering to the subject L-carnitine and an agent to increase blood plasma/serum insulin concentration to greater than 50 mU/L, wherein the amount of L-carnitine is 0.2
1. A method of increasing carnitine retention in human and/or animal skeletal muscle of a subject, the method comprising orally administering to the subject L-carnitine and an agent to increase blood plasma/serum insulin concentration to greater than 50 mU/L, wherein the amount of L-carnitine is 0.25 g to 3 g and the amount of the agent is 30 g to 450 g. 2. A method for promoting carnitine accumulation in skeletal muscle of a subject in need thereof comprising increasing the serum insulin concentration to greater than 50 mU/L in the subject and orally administering L-carnitine to the subject, wherein the amount of L-carnitine is 0.25 g to 3 g. 3. The method of claim 2, wherein the serum insulin is increased using an agent. 4. The method of claim 3, wherein the agent comprises a carbohydrate. 5. The method of claim 1, wherein the agent is operable to increase sodium dependent carnitine uptake into skeletal muscle. 6. The method of claim 1, wherein the agent is operable to increase insulin activity in skeletal muscle. 7. The method of claim 1, wherein the agent comprises a carbohydrate and/or an amino acid and/or a protein. 8. The method of claim 1, wherein the agent comprises a carbohydrate. 9. The method of claim 1, wherein the agent comprises an amino acid. 10. The method of claim 8, wherein the carbohydrate is a sugar. 11. The method of claim 8, wherein the carbohydrate comprises glucose, sucrose, and/or fructose. 12. The method of claim 1, wherein the amount by weight of the agent is between 10 and 150 times the amount by weight of said L-carnitine. 13. The method of claim 1, wherein the amount by weight of the agent is between 10 and 95 times the amount by weight of said L-carnitine. 14. The method of claim 1, wherein the amount by weight of the agent is between 10 and 40 times the amount by weight of said L-carnitine. 15. The method of claim 1, wherein the amount of L-carnitine is 0.25 g to 3 g and the amount of agent is 30 g to 120 g. 16. The method of claim 1, wherein the amount of L-carnitine is 0.25 g to 3 g and the amount of agent is 230 g to 285 g. 17. The method of claim 1, wherein the L-carnitine and the agent are in the form of a solution. 18. The method of claim 1, wherein the L-carnitine and the agent are in the form of an aqueous solution. 19. The method of claim 3, wherein the agent is operable to increase sodium dependent carnitine uptake into skeletal muscle. 20. The method of claim 3, wherein the agent is operable to increase insulin activity in skeletal muscle. 21. The method of claim 3, wherein the agent comprises a carbohydrate and/or an amino acid and/or a protein. 22. The method of claim 3, wherein the agent is a carbohydrate. 23. The method of claim 3, wherein the agent comprises an amino acid. 24. The method of claim 4, wherein the carbohydrate is a sugar. 25. The method of claim 4, wherein the carbohydrate comprises glucose, sucrose, and/or fructose. 26. The method of claim 3, wherein the amount by weight of the agent is between 10 and 150 times the amount by weight of said L-carnitine. 27. The method of claim 3, wherein the amount by weight of the agent is between 10 and 95 times the amount by weight of said L-carnitine. 28. The method of claim 3, wherein the amount by weight of the agent is between 10 and 40 times the amount by weight of said L-carnitine. 29. The method of claim 3, wherein the amount of agent is 30 g to 120 g. 30. The method of claim 3, wherein the amount of agent is 230 g to 285 g. 31. The method of claim 3, wherein the amount of agent is 30 g to 450 g. 32. The method of claim 2, wherein the L-carnitine is in the form of a solution. 33. The method of claim 2, wherein the L-carnitine is in the form of an aqueous solution. 34. The method of claim 2, wherein the serum insulin concentration in the subject is increased to greater than 50 mU/L and less than or equal to 70 mU/L.
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