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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0144651 (2016-05-02) |
등록번호 | US-9662461 (2017-05-30) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 5 인용 특허 : 884 |
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, inc
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
1. A dry powder inhaler comprising: at least one rigid air conduit and a housing configured to accept a cartridge, the cartridge comprising a lid anda movable container having a dry powder, the container configured to move relative to the cartridge lid from a storage position to a dispensing positio
1. A dry powder inhaler comprising: at least one rigid air conduit and a housing configured to accept a cartridge, the cartridge comprising a lid anda movable container having a dry powder, the container configured to move relative to the cartridge lid from a storage position to a dispensing position to form a flow path between one or more inlet ports and one or more dispensing ports within the inhaler; andwherein the dry powder inhaler is configured to emit greater than about 75% of a dry powder from the container as powder particles in a single inhalation, and the powder particles emitted have a volumetric median geometric diameter of less than about 5 microns when the single inhalation generates a peak inspiratory pressure of about 2 kPa within two seconds. 2. The dry powder inhaler of claim 1 having a resistance value to airflow ranging from about 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute. 3. The dry powder inhaler of claim 1, wherein the dry powder is a formulation for pulmonary delivery and comprises an amount from about 1 mg to about 30 mg of the dry powder. 4. The dry powder inhaler of claim 1, wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof. 5. The dry powder inhaler of claim 4, wherein the diketopiperazine is of the formula 3,6-bis(N-X-4-aminobutyl)-2,5-diketopiperazine, wherein X is selected from the group consisting of fumaryl, succinyl, maleyl, and glutaryl. 6. The method of claim 5, wherein the diketopiperazine is 7. The dry powder inhaler of claim 1, wherein the dry powder comprises a drug or an active agent. 8. The dry powder inhaler of claim 7, wherein the active agent is an endocrine hormone. 9. The dry powder inhaler of claim 1, wherein the dry powder comprises a peptide, a polypeptide, or fragments thereof, a small organic molecule or a nucleic acid molecule. 10. The dry powder inhaler of claim 9, wherein said peptide is insulin, glucagon, glucagon-like peptide-1, parathyroid hormone, oxytocin, oxyntomodulin, peptide YY, an exendin, analogs thereof or fragments thereof. 11. The dry powder inhaler of claim 9, wherein the small organic molecule is a vasodialator, a vasoconstrictor, a neurotransmitter agonist or a neurotransmitter antagonist. 12. The dry powder inhaler of claim 1, wherein the single inhalation generates an area under the curve (AUC) from a pressure versus time curve within one second of at least about 1.0, 1.1 or 1.2 kPa*sec. 13. The dry powder inhaler of claim 1, wherein the container is integrated into the housing and filled with a dry powder. 14. The dry powder inhaler of claim 1, wherein the inhaler does not include a cartridge. 15. The dry powder inhaler of claim 1, wherein the cartridge is provided separate from the inhaler and is filled with a dry powder. 16. A method of delivering of a dry powder using a high resistance dry powder inhaler comprising: a) providing a dry powder inhaler with an airflow resistance value ranging from about 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute, the inhaler containing a dose of the dry powder within a movable container configured to move within the inhaler from a storage position to a dispensing position to form a flow path between one or more inlet ports and one or more dispensing ports within the inhaler,b) applying sufficient force to reach a peak inspiratory pressure of at least 2 kPa within 2 seconds; andc) generating an area under the curve in the first second (AUC0-1 sex) of a inspiratory pressure versus time curve of at least about 1.0, 1.1 or 1.2 kPa*sec; wherein greater than 75% of the dose of the dry powder is discharged or emitted from the inhaler as powder particles. 17. The method of claim 16, wherein the dry powder is a formulation for pulmonary delivery and comprises an amount from about 1 mg to about 30 mg of the dry powder. 18. The method of claim 17, wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof. 19. The method of claim 18, wherein the diketopiperazine is of the formula 3,6-bis(N-X-4-aminobutyl)-2,5-diketopiperazine, wherein X is selected from the group consisting of fumaryl, succinyl, maleyl, and glutaryl. 20. The method of claim 19, wherein the diketopiperazine is
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