|국가/구분||United States(US) Patent 등록|
|국제특허분류(IPC7판)||A61K-038/10 C07K-014/47 A61K-038/45 A61K-038/46 C07K-007/08 G01N-033/573 A61K-038/17|
|발명자 / 주소|
|출원인 / 주소|
|대리인 / 주소||
|인용정보||피인용 횟수 : 0 인용 특허 : 18|
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.
1. A method for inhibiting prostate cancer cell growth in a subject in need thereof, the method comprising: administering an effective amount of an isolated peptide comprising the amino acid sequence of the Src-modulating peptide (P3) having SEQ ID NO:2, sufficient to inhibit prostate cancer cell growth. 2. The method of claim 1, wherein the isolated peptide is linked to a cell-penetrating peptide selected from the group consisting of: penatratin (TAT) having SEQ ID NO: 47, and atennapedia (AP) having SEQ ID NO: 48. 3. A method for inhibiting prostate ca...