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특허 상세정보

Methods of treatment of cancer using SRC-modulating peptides

국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-038/10    C07K-014/47    A61K-038/45    A61K-038/46    C07K-007/08    G01N-033/573    A61K-038/17   
출원번호 US-0607426 (2015-01-28)
등록번호 US-9663561 (2017-05-30)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    MacMillan, Sobanski & Todd, LLC
인용정보 피인용 횟수 : 0  인용 특허 : 18
초록

A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.

대표
청구항

1. A method for inhibiting prostate cancer cell growth in a subject in need thereof, the method comprising: administering an effective amount of an isolated peptide comprising the amino acid sequence of the Src-modulating peptide (P3) having SEQ ID NO:2, sufficient to inhibit prostate cancer cell growth. 2. The method of claim 1, wherein the isolated peptide is linked to a cell-penetrating peptide selected from the group consisting of: penatratin (TAT) having SEQ ID NO: 47, and atennapedia (AP) having SEQ ID NO: 48. 3. A method for inhibiting prostate ca...

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