Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-007/00
A61M-021/02
A61F-007/10
A61M-019/00
A61M-021/00
A61B-017/00
출원번호
US-0749590
(2015-06-24)
등록번호
US-9669185
(2017-06-06)
발명자
/ 주소
Nofzinger, Eric A.
출원인 / 주소
University of Pittsburgh—Of the Commonwealth System of Higher Education
대리인 / 주소
Shay Glenn LLP
인용정보
피인용 횟수 :
1인용 특허 :
132
초록
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to and/or during sleep to enhance sleep, which may be particularly beneficial to treat insomnia.
대표청구항▼
1. A method of enhancing sleep by non-invasively applying hypothermal therapy to at least a portion of a subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subje
1. A method of enhancing sleep by non-invasively applying hypothermal therapy to at least a portion of a subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex;maintaining the applicator temperature so that the thermal transfer region is cooled to between about 10° C. and about 25° C.;maintaining the temperature for a time period extending at least 15 minutes. 2. The method of claim 1, further comprising maintaining contact between the subject's skin over the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex and the thermal transfer region so that the metabolism in the cortex is slowed. 3. The method of claim 1, wherein positioning the applicator comprises securing the applicator in position. 4. The method of claim 1, wherein positioning the applicator comprises adhesively securing the applicator. 5. The method of claim 1, wherein positioning the applicator comprises securing the applicator over just the subject's forehead region. 6. The method of claim 1, further comprising ramping the temperature of the thermal transfer region from ambient temperature to the temperature between about 10° C. and about 25° C. over at least five minutes. 7. The method of claim 1, further comprising warming the thermal transfer region to a neutral temperature at the end of a night's sleep. 8. The method of claim 1, wherein maintaining the temperature comprises maintaining the temperature for at least 30 minutes. 9. The method of claim 1, wherein maintaining the temperature comprises maintaining the temperature for at least one hour. 10. The method of claim 1, further comprising changing the temperature of the thermal transfer region to a second temperature. 11. The method of claim 1, further comprising cooling the thermal transfer region to a second temperature that is between about 10° C. and 30° C. 12. The method of claim 11, wherein the second temperature is between about 20° C. and about 25° C. 13. The method of claim 11, further comprising maintaining the second temperature for a second time. 14. The method of claim 11, further comprising maintaining the second temperature for more than one hour. 15. The method of claim 11, further comprising maintaining the second temperature for more than four hours. 16. The method of claim 11, further wherein the second temperature is maintained by adjusting the temperature of the thermal transfer region based on feedback from the patient. 17. The method of claim 11, further wherein the second temperature is maintained by adjusting the temperature of the thermal transfer region based on subject selection of a user-selectable input. 18. The method of claim 1, wherein the method of enhancing sleep is a method of reducing sleep onset in a subject with insomnia. 19. A method of enhancing sleep by non-invasively applying hypothermal therapy to at least a portion of a subject's frontal cortex prefrontal cortex or frontal and prefrontal cortex, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex;cooling the thermal transfer region to between about 10° C. and about 25° C.; andmaintaining contact between the subject's skin over the at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex and the thermal transfer region for at least 15 minutes. 20. The method of claim 19, wherein maintaining contact comprises maintaining the contact between the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex and the thermal transfer region for at least 30 minutes. 21. The method of claim 19, further comprising warming the thermal transfer region to a neutral temperature. 22. The method of claim 19, further comprising cooling the thermal transfer region to a second temperature between about 10° C. and 25° C. 23. The method of claim 19, further comprising maintaining the temperature of the thermal transfer region between about 10° C. and about 25° C. 24. A method of enhancing sleep in a subject by non-invasively applying hypothermal therapy to at least a region of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex; andmaintaining, after the subject has fallen asleep, the thermal transfer region between about 10° C. and 25° C. for a first time period extending at least 30 minutes. 25. The method of claim 24, wherein maintain comprises maintaining the thermal transfer region between about 10° C. and about 18° C. 26. The method of claim 24, wherein positioning the applicator comprises adhesively securing the applicator. 27. The method of claim 24, wherein positioning the applicator comprises securing the applicator over the subject's forehead region. 28. The method of claim 24, wherein the method of enhancing sleep in a subject is a method of sustaining sleep in a subject with insomnia. 29. The method of claim 24, further comprising warming the thermal transfer region to a neutral temperature. 30. The method of claim 24, further comprising maintaining, after the subject has fallen asleep, the thermal transfer region at a second temperature between about 10° C. and 25° C. for a second time period. 31. The method of claim 30, further wherein the second temperature is maintained by adjusting the temperature of the thermal transfer region based on feedback from the patient. 32. The method of claim 30, further comprising ramping the temperature of the thermal transfer region from ambient temperature to the between about 10° C. and about 25° C. over at least five minutes. 33. The method of claim 30, further wherein the second temperature is maintained by adjusting the temperature of the thermal transfer region based on feedback from the patient. 34. A method of enhancing sleep in a subject by non-invasively applying hypothermal therapy to the subject's frontal cortex, prefrontal cortex, or frontal and prefrontal cortex, the method comprising: positioning an applicator comprising a thermal transfer region in communication with the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex, or frontal and prefrontal cortex;cooling the thermal transfer region to between about 10° C. and about 25° C.; andmaintaining, after the subject has fallen asleep, the thermal transfer region between about 10° C. and 25° C. while maintaining contact between the subject's skin over at least a portion of the subject's frontal cortex, prefrontal cortex or frontal and prefrontal cortex extending at least 30 minutes.
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이 특허에 인용된 특허 (132)
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