Method of altering the refractive properties of an eye
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-009/007
A61F-009/008
A61F-009/013
A61F-007/00
A61F-009/009
출원번호
US-0874453
(2015-10-04)
등록번호
US-9681984
(2017-06-20)
발명자
/ 주소
Peyman, Gholam A.
출원인 / 주소
Peyman, Gholam A.
대리인 / 주소
The Law Office of Patrick F. O'Reilly III, LLC
인용정보
피인용 횟수 :
0인용 특허 :
16
초록▼
The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and a
The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.
대표청구항▼
1. A method of altering the refractive properties of the eye, said method comprising: soaking a lens implant in a cross-linking solution that includes a photosensitizer, the lens implant having a predetermined shape for changing the refractive properties of an eye, and the lens implant including ant
1. A method of altering the refractive properties of the eye, said method comprising: soaking a lens implant in a cross-linking solution that includes a photosensitizer, the lens implant having a predetermined shape for changing the refractive properties of an eye, and the lens implant including anterior and posterior sides;forming a pocket in stromal tissue of a cornea of the eye, the pocket being circumscribed by a bounding wall formed from the stromal tissue;after the pocket in the cornea has been formed, inserting the lens implant with the photosensitizer thereon inside the pocket so that the photosensitizer permeates the stromal tissue that forms the bounding wall circumscribing the pocket and the anterior and posterior sides of the lens implant, the photosensitizer facilitating cross-linking of the stromal tissue that forms the bounding wall; andirradiating the cornea to activate cross-linkers in the stromal tissue that forms the bounding wall circumscribing the pocket so as to incorporate the lens implant within a portion of the stromal tissue devoid of keratocytes, stiffen the cornea, prevent corneal ectasia of the cornea, and prevent a rejection of the lens implant by the eye. 2. The method according to claim 1, wherein the step of inserting the lens implant with the photosensitizer thereon inside the pocket comprises inserting the lens implant using forceps or an injector. 3. The method according to claim 1, wherein the photosensitizer of the cross-linking solution comprises riboflavin. 4. The method according to claim 1, wherein the step of irradiating the cornea so as to activate cross-linkers in the portion of the tissue bounding the pocket comprises irradiating the cornea with at least one of ultraviolet light and microwaves. 5. The method according to claim 1, wherein the step of irradiating the cornea so as to activate cross-linkers in the portion of the tissue bounding the pocket comprises irradiating the cornea such that only a predetermined anterior stromal portion of the cornea to which the photosensitizer was applied is cross-linked, thereby leaving an anterior portion of the cornea and a posterior stromal portion of the cornea uncross-linked. 6. The method according to claim 1, wherein the step of forming the pocket in the cornea of the eye includes cutting the pocket using a femtosecond laser, the pocket being cut so as to have a diameter between about 10 millimeters and about 13 millimeters such that the diameter of the pocket is substantially equal to an overall diameter of the cornea from one side of the limbus to the other side of the limbus. 7. The method according to claim 1, wherein the lens implant is formed from an organic material. 8. The method according to claim 7, wherein the organic material forming the lens implant is transplanted corneal tissue. 9. The method according to claim 7, wherein the organic material forming the lens implant is tissue culture grown stromal material. 10. The method according to claim 1, wherein the lens implant is formed from a synthetic material. 11. The method according to claim 10, wherein the synthetic material forming the lens implant is a polymeric material. 12. The method according to claim 1, wherein the lens implant is formed from a porous organic material or a porous synthetic material. 13. The method according to claim 1, wherein the lens implant is formed by three-dimensional (3D) printing. 14. The method according to claim 13, wherein the lens implant is formed from a combination of organic and synthetic materials, a porous organic material, or a porous synthetic material. 15. A method of altering the refractive properties of the eye, said method comprising: soaking a porous lens implant in a cross-linking solution that includes a photosensitizer, the porous lens implant having a predetermined shape for changing the refractive properties of an eye, and the porous lens implant including anterior and posterior sides;forming a pocket in stromal tissue of a cornea of the eye by making an intrastromal incision across a width of the cornea, the pocket being circumscribed by a bounding wall formed from the stromal tissue;after the pocket in the cornea has been formed, inserting the porous lens implant with the photosensitizer thereon inside the pocket so that the photosensitizer permeates the stromal tissue that forms the bounding wall circumscribing the pocket and the anterior and posterior sides of the porous lens implant, the photosensitizer facilitating cross-linking of the stromal tissue that forms the bounding wall; andirradiating the porous lens implant and the cornea to simultaneously activate cross-linkers in the porous lens implant and in the stromal tissue that forms the bounding wall circumscribing the pocket so as to cross-link the porous lens implant and incorporate the porous lens implant within a portion of the stromal tissue devoid of keratocytes, stiffen the cornea, prevent corneal ectasia of the cornea, and prevent a rejection of the porous lens implant by the eye. 16. The method according to claim 15, wherein the bounding wall of the pocket extends across a central portion of the cornea of the eye.
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이 특허에 인용된 특허 (16)
Peyman,Gholam A., Adjustable inlay with multizone polymerization.
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