IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0537249
(2012-06-29)
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등록번호 |
US-9682229
(2017-06-20)
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발명자
/ 주소 |
- Wu, Paul H.
- Taylor, Catherine E.
- Williams, Terrel M.
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출원인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
3 |
초록
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An electrode of an implantable medical lead is coated with a polymeric composition that includes (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone; (ii) a copolymer formed from monomer subunits consisting essentially
An electrode of an implantable medical lead is coated with a polymeric composition that includes (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone; (ii) a copolymer formed from monomer subunits consisting essentially of vinyl acetate and alkyl methacrylate; and (iii) polyvinyl pyrrolidone. The coating does not substantially adversely affect impedance properties of the electrode.
대표청구항
▼
1. An implantable medical lead comprising: an electrode configured to contact tissue when implanted;a contact electrically coupled to the electrode, wherein the contact is configured to electrically couple the lead to a medical device; anda coating on the electrode, the coating comprising: (A) a pol
1. An implantable medical lead comprising: an electrode configured to contact tissue when implanted;a contact electrically coupled to the electrode, wherein the contact is configured to electrically couple the lead to a medical device; anda coating on the electrode, the coating comprising: (A) a polymer composition that includes (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone;(ii) a copolymer formed from monomer subunits consisting essentially of vinyl acetate and alkyl methacrylate; and(iii) polyvinyl pyrrolidone; and(B) optionally, one or more therapeutic agents,wherein the coating is otherwise free from electrically conductive material and does not substantially adversely affect impedance properties of the electrode. 2. The implantable medical lead of claim 1, wherein the polymer composition comprises from about 60 to about 70 weight percent of the terpolymer, from about 20 to about 30 weight percent of the copolymer, and from about 5 to about 15 weigh percent of the polyvinyl pyrrolidone. 3. The implantable medical lead of claim 1, wherein the polymer composition comprises about 63 weight percent of the terpolymer, about 27 weight percent of the copolymer, and about 10 weight percent of the polyvinyl pyrrolidone. 4. The implantable medical lead of claim 1, wherein the relative mole percent of the monomer subunits of the terpolymer comprises from about 2% to about 30% vinyl acetate, from about 40% to about 77% alkyl methyl acrylate, and from about 15% to about 30% n-vinyl pyrrolidone. 5. The implantable medical lead of claim 1, wherein the relative mole percent of the monomer subunits of the copolymer comprises from about 2% to about 70% vinyl acetate and from about 30% to about 97% alkyl methyl acrylate. 6. The implantable medical lead of claim 1, wherein the alkyl methacrylate of the terpolymer and the alkyl methacrylate of the copolymer are independently selected from the group consisting of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, pentyl methacrylate, and hexyl methacrylate. 7. The implantable medical lead of claim 1, wherein the alkyl methacrylate of the terpolymer is n-hexyl methacrylate and wherein the alkyl methacrylate of the copolymer is n-butyl methacrylate. 8. The implantable medical lead of claim 1, wherein the coating further comprises a therapeutic agent(s). 9. The implantable medical lead of claim 8, wherein the one or more therapeutic agents comprises a therapeutic agent is selected from the group consisting of an anti-inflammatory agent and an antimicrobial agent. 10. The implantable medical lead of claim 8, wherein the one or more therapeutic agents comprise an anti-inflammatory agent. 11. The implantable medical lead of claim 8, wherein the one or more therapeutic agents comprise a steroid. 12. The implantable medical lead of claim 8, wherein the one or more therapeutic agents comprise beclomethasone or a pharmaceutically acceptable salt thereof. 13. The implantable medical lead of claim 8, wherein the one or more therapeutic agent agents comprise beclomethasone dipropionate. 14. The implantable medical lead of claim 1, wherein the electrode is a helix electrode. 15. The implantable medical lead of claim 1, wherein the coating does not increase the impedance of the electrode more than 10% relative to the same electrode coated with beclomethasone dipropionate alone. 16. The implantable medical lead of claim 1, wherein the coating decreases the impedance of the electrode relative to an uncoated electrode. 17. A system comprising: an implantable medical lead according to claim 1; anda medical device to which the lead is configured to operably couple. 18. A method comprising: coating an electrode with a polymer composition comprising (i) a terpolymer formed from monomer subunits consisting essentially of vinyl acetate, alkyl methyl acrylate and n-vinyl pyrrolidone; (ii) a copolymer formed from monomer subunits consisting essentially of vinyl acetate and alkyl methacrylate; and (iii) polyvinyl pyrrolidone; and (B) optionally, one or more therapeutic agents, wherein the coating is otherwise free form electrically conductive material and does not substantially adversely affect impedance properties of the electrode; andincorporating the coated electrode into an implantable medical lead during assembly of the lead. 19. The method of claim 18, wherein coating the electrode comprises electro-nano-spraying the electrode with the polymer composition. 20. The method of claim 18, wherein the coating composition comprises the one or more therapeutic agents.
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