Methods and apparatus for cleaning or disinfecting a water delivery system
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-002/00
A61B-001/00
B08B-003/00
A01K-007/00
B08B-009/08
A61K-031/575
A01N-033/08
A01N-037/44
B08B-009/027
B08B-003/08
C02F-001/50
A01N-045/00
C02F-001/68
출원번호
US-0694028
(2015-04-23)
등록번호
US-9686966
(2017-06-27)
발명자
/ 주소
Beus, Chad S.
Savage, Paul B.
출원인 / 주소
BRIGHAM YOUNG UNIVERSITY
대리인 / 주소
Workman Nydegger
인용정보
피인용 횟수 :
0인용 특허 :
33
초록▼
Methods for cleaning or disinfecting water delivery systems, self-cleaning or self-disinfecting water delivery systems, and inserts for use in cleaning or disinfecting water delivery systems utilize cationic steroidal antimicrobial (CSA) molecules to kill microbes and/or break up biofilms within wat
Methods for cleaning or disinfecting water delivery systems, self-cleaning or self-disinfecting water delivery systems, and inserts for use in cleaning or disinfecting water delivery systems utilize cationic steroidal antimicrobial (CSA) molecules to kill microbes and/or break up biofilms within water delivery systems. The methods and systems involve adding CSA molecules to water to form an aqueous CSA composition and passing the aqueous CSA composition through the water delivery system, such as a water storage vessel and/or water delivery line to clean or disinfect the water delivery system. CSA molecules can be added to a water storage vessel, water delivery line, or well, such as by a solid or liquid CSA composition. A CSA-eluting composition may provide CSA molecules to water to form an aqueous CSA composition that passes through or is stored within the water delivery system. CSA molecules provided to agricultural animals in drinking water may improve animal health.
대표청구항▼
1. A method for cleaning or disinfecting a water delivery system, including breaking up biofilms, used in providing a supply of drinking water to a human or animal, comprising: adding cationic steroidal antimicrobial (CSA) molecules to water to form an aqueous CSA composition; andpassing the aqueous
1. A method for cleaning or disinfecting a water delivery system, including breaking up biofilms, used in providing a supply of drinking water to a human or animal, comprising: adding cationic steroidal antimicrobial (CSA) molecules to water to form an aqueous CSA composition; andpassing the aqueous CSA composition through a water delivery line of the water delivery system to break up biofilms in the water delivery line. 2. A method as in claim 1, wherein the water delivery line provides drinking water to animals. 3. A method as in claim 2, wherein the water delivery line provides drinking water to at least one of cattle, horses, sheep, swine, or poultry. 4. A method as in claim 2, wherein the water delivery line provides drinking water to at least one of turkeys or chickens. 5. A method as in claim 2, wherein the drinking water provides a quantity of CSA molecules in order to improve the health of the animals. 6. A method as in claim 1, wherein the water delivery line provides drinking water to humans. 7. A method as in claim 1, wherein the CSA molecules form complexes with metal ions or metal compounds in water passing through the water delivery line. 8. A method as in claim 1, further comprising combining the CSA molecules with a liquid or solid to form a CSA delivery composition and contacting the CSA delivery composition with water in the water delivery line to form the aqueous CSA composition. 9. A method as in claim 1, wherein the water delivery line forms part of a water delivery system comprised of a water storage vessel or well and one or more water lines in fluid communication with the water storage vessel or well that transport water to one or more locations. 10. A method as in claim 9, wherein the one or more water lines comprise a plurality of pipes or conduits. 11. A method as in claim 10, wherein the pipes or conduits are made of metal. 12. A method as in claim 9, wherein the CSA molecules are added to water in the storage vessel or well. 13. A method as in claim 9, further comprising mixing the CSA molecules with water to form a concentrated CSA composition and introducing the concentrated CSA composition into at least one of the storage vessel, well, or one or more water lines. 14. A method as in claim 1, wherein the aqueous CSA composition is periodically passed through the water delivery line, and wherein water without the CSA molecules is periodically passed through the water delivery line. 15. A method as in claim 1, further comprising applying a CSA-eluting composition to an interior surface of the water delivery line, the CSA-eluting composition releasing at least a portion of the CSA molecules added to the water to form the aqueous CSA composition. 16. A method as in claim 1, further comprising applying a CSA-eluting composition to an interior surface of a water storage vessel upstream from the water delivery line, the CSA-eluting composition releasing at least a portion of the CSA molecules added to the water to form the aqueous CSA composition. 17. A method as in claim 1, wherein at least a portion of the CSA molecules are provided by a CSA-containing tablet, powder, or eluting device. 18. A method as in claim 17, the method comprising placing the CSA-containing tablet, powder, or eluting device into a storage vessel upstream from the water delivery line. 19. A method as in claim 1, wherein the water delivery line has a length of at least 1 meter, 5 meters, 10 meters, 25 meters, 50 meters, 100 meters, 1000 meters, or 5 kilometers. 20. A method as in claim 1, wherein the water delivery system comprises a water storage vessel having a capacity of at least 10 liters, 50 liters, 100 liters, 500 liters, 1000 liters, 5000 liters, 10,000 liters, or 100,000 liters. 21. A method as in claim 1, wherein the water delivery system comprises at least one water storage vessel of a confined animal feed operation. 22. A method as in claim 1, wherein the water delivery system comprises at least one water storage vessel that provides drinking water to at least one of a house, building, or human. 23. A method for cleaning or disinfecting a water delivery line, including breaking up biofilms, that delivers drinking water to animals, comprising: adding cationic steroidal antimicrobial (CSA) molecules to the water delivery line to form an aqueous CSA composition; andpassing the aqueous CSA composition through the water delivery line to break up biofilms in the water delivery line and provide water that is safe for animals to drink. 24. A method as in claim 23, further comprising introducing water from the water delivery line to a drinking trough or vessel from which one or more animals drink. 25. A method as in claim 23, wherein the aqueous CSA composition provides a quantity of CSA molecules that, when ingested by the animals, improves the health of the animals. 26. A method as in claim 23, wherein the animals are located in a confined animal feed operation. 27. A method as in claim 23, wherein the animals are selected from the group of cattle, horses, sheep, swine, poultry, and combinations thereof. 28. A method as in claim 23, wherein the CSA molecules provide at least one of the following: reduced harmful bacteria in a digestive tract of an animal;increased beneficial bacteria flora in the digestive tract of the animal;improved feed conversion efficiency by the animal;reduced morbidity of the animal;reduced mortality of the animal; orharvested meat from the animal having a reduced content of harmful bacteria. 29. A method for cleaning or disinfecting a water delivery system, including breaking up biofilms, comprised of a water storage vessel or well and a water delivery line in fluid communication with the water storage vessel or well, the method comprising: adding cationic steroidal antimicrobial (CSA) molecules to water to form an aqueous CSA composition having a concentration of CSA molecules in a range of 0.5 ppm to 5000 ppm; andpassing the aqueous CSA composition through at least one of the water delivery line or the water storage vessel or well to break up biofilms within the at least one of the water delivery line or the water storage vessel or well. 30. A method as in claim 29, wherein the water delivery system provides drinking water to animals or humans. 31. A method as in claim 29, wherein the water delivery system is configured to deliver water to houses and buildings. 32. A method as in claim 29, wherein the water delivery system comprises the well, and wherein adding the CSA molecules to water to form the aqueous CSA composition comprises introducing the CSA molecules into the well. 33. A method as in claim 29, wherein the water delivery system comprises the water storage vessel, and wherein adding the CSA molecules to water to form the aqueous CSA composition comprises introducing the CSA molecules into the water storage vessel. 34. A method as in claim 33, wherein the water storage vessel comprises a drinking trough or vessel from which one or more animals drink. 35. A method as in claim 34, wherein the one or more animals are located in a confined animal feed operation. 36. A method as in claim 34, wherein the one or more animals are selected from the group of cattle, horses, sheep, swine, poultry, and combinations thereof. 37. A method as in claim 29, wherein the cationic steroidal antimicrobial (CSA) molecules include one or more compounds according to Formula (I), or a salt thereof: whereinrings A, B, C, and D are independently saturated, or are fully or partially unsaturated, provided that at least two of rings A, B, C, and D are saturated;m, n, p, and q are independently 0 or 1;R1-R18 are substituent groups attached to one of rings A, B, C, or D; wherein R1-R18 are independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted alkyl, a substituted or unsubstituted hydroxyalkyl, a substituted or unsubstituted alkyloxyalkyl, a substituted or unsubstituted alkylcarboxyalkyl, a substituted or unsubstituted alkylaminoalkyl, a substituted or unsubstituted alkylaminoalkylamino, a substituted or unsubstituted alkylaminoalkylaminoalkylamino, a substituted or unsubstituted aminoalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted arylaminoalkyl, a substituted or unsubstituted haloalkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted aminoalkyloxy, a substituted or unsubstituted aminoalkyloxyalkyl, a substituted or unsubstituted aminoalkylcarboxy, a substituted or unsubstituted aminoalkylaminocarbonyl, a substituted or unsubstituted aminoalkyl-carboxamido, a substituted or unsubstituted di(alkyl)aminoalkyl, a substituted or unsubstituted C-carboxyalkyl; H2N—HC(Q5)-C(O)—O—, H2NHC(Q5)-C(O)—N(H)—, a substituted or unsubstituted azidoalkyloxy, a substituted or unsubstituted cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted guanidinoalkyloxy, a substituted or unsubstituted quaternary ammonium alkylcarboxy, and a substituted or unsubstituted guanidinoalkyl carboxy, where Q5 is a side chain of an amino acid, and P.G. is an amino protecting group. 38. A method as in claim 37, wherein: R1 through R4, R6, R7, R11, R12, R15, R16, and R18 are independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted alkyl, a substituted or unsubstituted hydroxyalkyl, a substituted or unsubstituted alkyloxyalkyl, a substituted or unsubstituted alkylcarboxyalkyl, a substituted or unsubstituted alkylaminoalkyl, a substituted or unsubstituted alkylaminoalkylamino, a substituted or unsubstituted alkylaminoalkyl-aminoalkylamino, a substituted or unsubstituted aminoalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted arylaminoalkyl, a substituted or unsubstituted haloalkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted aminoalkyloxy, a substituted or unsubstituted aminoalkyloxyalkyl, a substituted or unsubstituted aminoalkylcarboxy, a substituted or unsubstituted aminoalkylaminocarbonyl, a substituted or unsubstituted aminoalkylcarboxamido, a substituted or unsubstituted di(alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, a substituted or unsubstituted azidoalkyloxy, a substituted or unsubstituted cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted guanidinoalkyloxy, a substituted or unsubstituted quaternary ammonium alkylcarboxy, and a substituted or unsubstituted guanidinoalkyl carboxy, where Q5 is a side chain of an amino acid, and P.G. is an amino protecting group; andR5, R8, R9, R10, R13, R14 and R17 are independently deleted when one of rings A, B, C, or D is unsaturated so as to complete the valency of the carbon atom at that site, or R5, R8, R9, R10, R13, and R14 are independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted alkyl, a substituted or unsubstituted hydroxyalkyl, a substituted or unsubstituted alkyloxyalkyl, a substituted or unsubstituted aminoalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted haloalkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted aminoalkyloxy, a substituted or unsubstituted aminoalkylcarboxy, a substituted or unsubstituted aminoalkylaminocarbonyl, a substituted or unsubstituted di(alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, azidoalkyloxy, cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, guanidinoalkyloxy, and guanidinoalkylcarboxy, where Q5 is a side chain of an amino acid, P.G. is an amino protecting group,provided that at least two of R1-4, R6, R7, R11, R12, R15, R16, R17, and R18 are independently selected from the group consisting of a substituted or unsubstituted aminoalkyl, a substituted or unsubstituted aminoalkyloxy, a substituted or unsubstituted alkylcarboxyalkyl, a substituted or unsubstituted alkylaminoalkylamino, a substituted or unsubstituted alkyl aminoalkyl-aminoalkyl amino, a substituted or unsubstituted aminoalkylcarboxy, a substituted or unsubstituted arylaminoalkyl, a substituted or unsubstituted aminoalkyloxyaminoalkylaminocarbonyl, a substituted or unsubstituted aminoalkylaminocarbonyl, a substituted or unsubstituted aminoalkyl-carboxyamido, a quaternary ammonium alkylcarboxy, a substituted or unsubstituted di(alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, azidoalkyloxy, cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted guanidinoalkyloxy, and a substituted or unsubstituted guanidinoalkylcarboxy. 39. A method as in claim 37, wherein R1 through R4, R6, R7, R11, R12, R15, R16, and R18 are independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted (C1-C18) alkyl, a substituted or unsubstituted (C1-C18) hydroxyalkyl, a substituted or unsubstituted (C1-C18) alkyloxy-(C1-C18) alkyl, a substituted or unsubstituted (C1-C18) alkylcarboxy-(C1-C18) alkyl, a substituted or unsubstituted (C1-C18) alkylamino-(C1-C18)alkyl, a substituted or unsubstituted (C1-C18) alkylamino-(C1-C18) alkylamino, a substituted or unsubstituted (C1-C18) alkylamino-(C1-C18) alkylamino-(C1-C18) alkylamino, a substituted or unsubstituted (C1-C18) aminoalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted arylamino-(C1-C18) alkyl, a substituted or unsubstituted (C1-C18) haloalkyl, a substituted or unsubstituted C2-C6 alkenyl, a substituted or unsubstituted C2-C6 alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted (C1-C18) aminoalkyloxy, a substituted or unsubstituted (C1-C18) aminoalkyloxy-(C1-C18) alkyl, a substituted or unsubstituted aminoalkylcarboxy, a substituted or unsubstituted (C1-C18) aminoalkylaminocarbonyl, a substituted or unsubstituted (C1-C18) aminoalkylcarboxamido, a substituted or unsubstituted di(C1-C18 alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, a substituted or unsubstituted (C1-C18) azidoalkyloxy, a substituted or unsubstituted (C1-C18) cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted (C1-C18) guanidinoalkyloxy, a substituted or unsubstituted (C1-C18) quaternary ammonium alkylcarboxy, and a substituted or unsubstituted (C1-C18) guanidinoalkyl carboxy, where Q5 is a side chain of an amino acid, and P.G. is an amino protecting group;R5, R8, R9, R10, R13, R14 and R17 are independently deleted when one of rings A, B, C, or D is unsaturated so as to complete the valency of the carbon atom at that site, or R5, R8, R9, R10, R13, and R14 are independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted (C1-C18) alkyl, a substituted or unsubstituted (C1-C18) hydroxyalkyl, a substituted or unsubstituted (C1-C18) alkyloxy-(C1-C18) alkyl, a substituted or unsubstituted (C1-C18) aminoalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (C1-C18) haloalkyl, a substituted or unsubstituted (C2-C6) alkenyl, a substituted or unsubstituted (C2-C6) alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted (C1-C18) aminoalkyloxy, a substituted or unsubstituted (C1-C18) aminoalkylcarboxy, a substituted or unsubstituted (C1-C18) aminoalkylaminocarbonyl, a substituted or unsubstituted di(C1-C18 alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, a substituted or unsubstituted (C1-C18) azidoalkyloxy, a substituted or unsubstituted (C1-C18) cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted (C1-C18) guanidinoalkyloxy, and (C1-C18) guanidinoalkylcarboxy, where Q5 is a side chain of an amino acid, and P.G. is an amino protecting group;provided that at least three of R1-4, R6, R7, R11, R12, R15, R16, R17, and R18 are independently selected from the group consisting of a substituted or unsubstituted (C1-C18) aminoalkyl, a substituted or unsubstituted (C1-C18) aminoalkyloxy, a substituted or unsubstituted (C1-C18) alkylcarboxy-(C1-C18) alkyl, a substituted or unsubstituted (C1-C18) alkylamino-(C1-C18) alkylamino, a substituted or unsubstituted (C1-C18) alkylamino-(C1-C18) alkylamino (C1-C18) alkylamino, a substituted or unsubstituted (C1-C18) aminoalkylcarboxy, a substituted or unsubstituted arylamino (C1-C18) alkyl, a substituted or unsubstituted (C1-C18) aminoalkyloxy (C1-C18) aminoalkylaminocarbonyl, a substituted or unsubstituted (C1-C18) aminoalkylaminocarbonyl, a substituted or unsubstituted (C1-C18) aminoalkylcarboxyamido, a substituted or unsubstituted (C1-C18) quaternary ammonium alkylcarboxy, a substituted or unsubstituted di(C1-C18 alkyl)aminoalkyl, H2N—HC(Q5)-C(O)—O—, H2N—HC(Q5)-C(O)—N(H)—, a substituted or unsubstituted (C1-C18) azidoalkyloxy, a substituted or unsubstituted cyanoalkyloxy, P.G.-HN—HC(Q5)-C(O)—O—, a substituted or unsubstituted guanidinoalkyloxy, and a substituted or unsubstituted (C1-C18) guanidinoalkylcarboxy. 40. A method as in claim 37, wherein the one or more compounds of Formula (I) or salt thereof comprise a compound of Formula (IB): 41. A method as in claim 40, wherein R3, R7, and R12 are each independently aminoalkyloxy or aminoalkylcarboxy. 42. A method as in claim 41, wherein Rig is selected from the group consisting of: alkylaminoalkyl, di(alkyl)aminoalkyl, alkoxycarbonylalkyl, alkylcarboxyalkyl, and C-carboxyalkyl. 43. A method as in claim 37, wherein the CSA molecules are selected from the group consisting of: and salts thereof. 44. A self-cleaning or self-disinfecting water delivery system configured to break up biofilms in the water delivery system and provide a supply of drinking water to a human or animal, comprising: at least one of a water delivery line or a water storage vessel configured to provide a supply of drinking water to a human or animal; anda cationic steroidal antimicrobial (CSA)-eluting composition positioned on an interior surface of the water delivery line and/or placed within the water storage vessel, wherein the CSA-eluting composition is formulated to release CSA molecules into water in the water delivery line and/or water storage vessel over time and in a concentration in order for the water delivery system to break up biofilms forming on an interior surface of the at least one of the water delivery line or the water storage vessel. 45. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the CSA-eluting composition comprises a CSA-eluting composition positioned on an interior surface of the water delivery line and/or water storage vessel. 46. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the CSA-eluting composition comprises a CSA-releasing tablet, CSA-releasing powder, or CSA-eluting device. 47. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the water delivery system includes one or more water tanks positionable upstream of one or more water lines. 48. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the water storage vessel is an animal drinking trough or vessel. 49. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the water storage vessel is configured to provide drinking water to one or more animals in a confined animal feed operation. 50. A self-cleaning or self-disinfecting water delivery system as in claim 44, wherein the water storage vessel is configured to provide drinking water to one or more of cattle, horses, sheep, swine, or poultry. 51. A cationic steroidal antimicrobial (CSA)-releasing insert for attachment to and cleaning or disinfecting of a water delivery system and for breaking up biofilms in the water delivery system, the CSA-releasing insert comprising: an insert substrate for placement on or within a water storage vessel or water delivery line; anda CSA-eluting composition on a surface of or impregnated in the insert substrate, wherein the CSA-eluting composition is formulated to release CSA molecules into water within a water storage vessel or water delivery line and form an aqueous CSA composition having a concentration of CSA molecules in a range of 0.00005% to 5% by weight of the aqueous CSA composition, wherein the concentration of CSA molecules released by the CSA-eluting composition acts to break up biofilms in the water delivery system when in use. 52. A CSA-releasing insert as in claim 51, wherein the insert comprises a pipe configured to temporarily or permanently form part of the water delivery line. 53. A CSA-releasing insert as in claim 51, wherein the insert substrate is sized and configured for attachment to an interior surface or region of the water storage vessel or water delivery line.
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