초록 ▼

A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a

A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.

대표청구항 ▼

1. A microsphere comprising: an oxidized cellulose; andat least one bioactive agent. 2. The microsphere according to claim 1, wherein the bioactive agent is selected from the group consisting of a hydrophilic bioactive agent, a protein bioactive agent, and combinations thereof. 3. The microsphere ac

1. A microsphere comprising: an oxidized cellulose; andat least one bioactive agent. 2. The microsphere according to claim 1, wherein the bioactive agent is selected from the group consisting of a hydrophilic bioactive agent, a protein bioactive agent, and combinations thereof. 3. The microsphere according to claim 1, wherein the microsphere is formed by: contacting an oxidized cellulose solution comprising a solvent with the at least one bioactive agent to form a discontinuous phase liquid;contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; andcontacting the emulsion with a third phase liquid to extract the solvent from the emulsion thereby forming a plurality of microspheres. 4. The microsphere according to claim 3, wherein the third phase liquid is miscible with the continuous phase liquid and the discontinuous phase liquid. 5. The microsphere according to claim 3, wherein the third phase liquid is selected from the group consisting of isopropyl myristate, hexane, triglycerides and combinations thereof. 6. The microsphere according to claim 3, wherein the third phase liquid is present in an amount from about 130% by volume to about 170% by volume of the continuous phase liquid. 7. The microsphere according to claim 3, further comprising forming the oxidized cellulose solution by: contacting an oxidized cellulose with the solvent under an inert atmosphere to form a swelled oxidized cellulose;adjusting the swelled oxidized cellulose mixture to a first temperature;contacting the swelled oxidized cellulose after adjusting the first temperature with a salt under the inert atmosphere to form an oxidized cellulose solution; andadjusting the oxidized cellulose solution to a second temperature. 8. The microsphere according to claim 7, wherein the first temperature is from about 115° C. to about 145° C. and the second temperature is from about 90° C. to about 120° C. 9. The microsphere according to claim 7, wherein the solvent is selected from the group consisting of N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, and combinations thereof. 10. The microsphere according to claim 7, wherein the salt is selected from the group consisting of lithium halides, sodium halides, potassium halides, and combinations thereof. 11. The microsphere according to claim 3, wherein the continuous phase liquid is selected from the group consisting of plant-based oils, petroleum-based oils, silicone-based oils, and combinations thereof. 12. The microsphere according to claim 3, wherein the third phase liquid is miscible with the continuous phase liquid and immiscible with the discontinuous phase liquid. 13. The microsphere according to claim 3, wherein the third phase liquid is present in an amount from about 8.33% by volume to about 11.11% by volume of the continuous phase liquid. 14. The microsphere according to claim 1, wherein the at least one bioactive agent is hydrophobic.