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A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfact

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

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1. A double-structured tissue implant product made by a process comprising: providing a primary scaffold comprising a first collagen and a plurality of pores;preparing a composition comprising a second collagen and a surfactant;introducing the composition into the plurality of pores of the primary s

1. A double-structured tissue implant product made by a process comprising: providing a primary scaffold comprising a first collagen and a plurality of pores;preparing a composition comprising a second collagen and a surfactant;introducing the composition into the plurality of pores of the primary scaffold; andstabilizing the composition within the plurality of pores of the primary scaffold through precipitation, dehydration, and lyophilization to produce a double-structured tissue implant. 2. The double-structured tissue implant product of claim 1, wherein the primary scaffold comprises Type I collagen. 3. The double-structured tissue implant product of claim 2, wherein the second collagen comprises Type I or Type II collagen. 4. The double-structured tissue implant product of claim 1, wherein the surfactant is a non-ionic surfactant. 5. The double-structured tissue implant product of claim 4, wherein the non-ionic surfactant is a polymeric compound. 6. The double-structured tissue implant product of claim 1, wherein the surfactant is an ionic surfactant. 7. The double-structured tissue implant product of claim 1, wherein the composition is soluble in water. 8. The double-structured tissue implant product of claim 1, wherein the composition comprises cells. 9. The double-structured tissue implant product of claim 1, wherein the composition comprises at least one pharmaceutical agent. 10. The double-structured tissue implant product of claim 9, wherein the pharmaceutical agent is a drug. 11. The double-structured tissue implant product of claim 1, wherein the composition comprises a growth modulator. 12. The double-structured tissue implant product of claim 1, further comprising subjecting the double-structured tissue implant to a dehydrothermal treatment. 13. The double-structured tissue implant product of claim 12, wherein the dehydrothermal treatment comprises subjecting the double-structured tissue implant to temperatures in a range from about 70 degrees C. to about 200 degrees C. under vacuum for about 30 minutes to about 7 days. 14. The double-structured tissue implant product of claim 12, wherein the dehydrothermal treatment comprises subjecting the double-structured tissue implant to temperatures from about 130 degrees C. to about 150 degrees C. under vacuum for about 5-7 hours.