[특허]Ferroportin antibodies and methods of use

Ferroportin antibodies and methods of use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07K-016/28 G01N-033/68 G01N-033/90 A61K-038/18 A61K-039/395 A61K-039/00
출원번호	US-0866105 (2015-09-25)
등록번호	US-9688759 (2017-06-27)
발명자 / 주소	Arvedson, Tara Dyas, Gregory Rottman, James B. Sasu, Barbra Bi, Xiao-juan Lee, Grace Ki Jeong Sheng, Jackie Z.
출원인 / 주소	Amgen, Inc.
대리인 / 주소	Bugaisky, Lawrence
인용정보	피인용 횟수 : 0 인용 특허 : 76

초록

Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

대표청구항 ▼

1. A method for increasing hemoglobin or hematocrit in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an isolated monoclonal antibody that binds to an extracellular domain of human ferroportin and preserves ferroportin activity, wherein the monoclonal antibody binds to an epitope comprising amino acids 417-426 of SEQ ID NO: 16. 2. The method of claim 1, wherein the monoclonal antibody competes for binding to human ferroportin by at least 75% with an antibody comprising: (i) a heavy chain variable region of SEQ ID NO: 4 and a light chain variable region of SEQ ID NO: 2;(ii) a heavy chain variable region of SEQ ID NO: 28 and a light chain variable region of SEQ ID NO: 26;(iii) a heavy chain variable region of SEQ ID NO: 38 and a light chain variable region of SEQ ID NO: 36;(iv) a heavy chain variable region of SEQ ID NO: 48 and a light chain variable region of SEQ ID NO: 46;(v) a heavy chain variable region of SEQ ID NO: 58 and a light chain variable region of SEQ ID NO: 56;(vi) a heavy chain variable region of SEQ ID NO: 68 and a light chain variable region of SEQ ID NO: 66;(vii) a heavy chain variable region of SEQ ID NO: 78 and a light chain variable region of SEQ ID NO: 76;(viii) a heavy chain variable region of SEQ ID NO: 98 and a light chain variable region of SEQ ID NO: 96; or(ix) a heavy chain variable region of SEQ ID NO: 108 and a light chain variable region of SEQ ID NO: 106. 3. The method of claim 1, wherein the monoclonal antibody is a chimerized antibody, a humanized antibody, or a fully human antibody. 4. The method of claim 1, wherein the monoclonal antibody is an IgG1, IgG2, IgG3, or IgG4 antibody. 5. The method of claim 1, wherein the subject has a disorder of iron homeostasis. 6. The method of claim 5, wherein the disorder of iron homeostasis is anemia, anemia of inflammation, anemia of cancer, chemotherapy induced anemia, chronic inflammatory anemia, end stage renal disorder, chronic kidney disease (stage I, II, III, IV, or V), or iron deficiency anemia. 7. The method of claim 1, wherein the subject has a serum iron level outside of the range of 50 to 170 μg/dL. 8. The method of claim 1, wherein the therapeutically effective amount of the monoclonal antibody is effective to increase the red blood cell count in the subject following administration. 9. The method of claim 1, further comprising administering to the subject an erythropoiesis stimulator. 10. The method of claim 1, wherein the erythropoiesis stimulator is erythropoietin or variants thereof. 11. The method of claim 1, wherein the monoclonal antibody is administered to the subject by a parenteral route of administration. 12. The method of claim 1, wherein the monoclonal antibody is administered to the subject via an intravenous or subcutaneous injection.

이 특허에 인용된 특허 (76)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Ferroportin antibodies and methods of use 원문보기

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Ferroportin antibodies and methods of use 원문보기

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