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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0742137 (2015-06-17) |
등록번호 | US-9693721 (2017-07-04) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 399 |
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The se
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
1. A device for in vivo measurement of a glucose concentration, the device comprising: a transcutaneous sensor configured to measure a signal indicative of a glucose concentration in a host, wherein the sensor comprises an electroactive surface; anda membrane located over the sensor, wherein the mem
1. A device for in vivo measurement of a glucose concentration, the device comprising: a transcutaneous sensor configured to measure a signal indicative of a glucose concentration in a host, wherein the sensor comprises an electroactive surface; anda membrane located over the sensor, wherein the membrane comprises: a second domain comprising a polymer comprising a plurality of repeating hard segments and repeating soft segments, wherein a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons, wherein the polymer comprises a hydrophilic segment, wherein the second domain comprises both hydrophilic and hydrophobic regions, whereby diffusion of glucose and oxygen through the second domain is controlled; andsensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration. 2. The device of claim 1, wherein the polymer is a polyurethaneurea. 3. The device of claim 1, wherein the hydrophilic segment comprises acrylate. 4. The device of claim 1, wherein the membrane comprises a third domain configured to reduce permeation therethrough of an interfering species. 5. The device of claim 4, further comprising a first domain comprising an enzyme configured to react with glucose to produce a measured species, wherein the third domain is located between the sensor and the first domain. 6. The device of claim 4, wherein the third domain comprises a polymer comprising ionic components. 7. The device of claim 4, wherein the third domain is configured to limit diffusion of interfering species with a molecular weight greater than a molecular weight of hydrogen peroxide. 8. The device of claim 1, wherein the polymer is polyurethaneurea, wherein the hydrophilic segment comprises acrylate. 9. The device of claim 1, wherein the polymer is polyurethaneurea, wherein the hydrophilic segment comprises acrylate, wherein the membrane comprises a third domain configured to reduce permeation therethrough of an interfering species. 10. The device of claim 1, further comprising a first domain comprising an enzyme configured to react with glucose to produce a measured species, wherein the polymer is polyurethaneurea, wherein the hydrophilic segment comprises acrylate, wherein the membrane comprises a third domain configured to reduce permeation therethrough of an interfering species, wherein the third domain is located between the sensor and the first domain. 11. The device of claim 1, wherein the hydrophilic segment is selected from the group consisting of: polyvinyl acetate, poly(ethylene glycol), polyacrylamide, acetates, polyethylene oxide, polyvinylpyrrolidone, and poly ethyl acrylate. 12. The device of claim 1, wherein the polyurethane polymer comprises silicone. 13. The device of claim 12, wherein the polymer comprises from about 10% to about 50% silicone by weight. 14. The device of claim 13, wherein the polymer comprises from about 20% to about 40% silicone by weight. 15. The device of claim 1, wherein the polymer is polyurethaneurea, wherein the hydrophilic segment comprises acrylate, wherein the polyurethane polymer comprises silicone. 16. The device of claim 1, wherein the polymer comprising the hydrophilic segment comprises from about 5% to about 50% by weight of the blend. 17. The device of claim 1, wherein the polyurethane polymer is polyurethaneurea, wherein the hydrophilic segment comprises acrylate, wherein the polymer comprising the hydrophilic segment comprises from about 5% to about 50% by weight of the blend. 18. The device of claim 1, wherein the device is configured to have a sensor session from 5 to 10 days. 19. The device of claim 1, wherein the sensor is configured to continuously measure a signal indicative of a glucose concentration in a host.
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