[특허]Liquid compositions capable of foaming and including active agents, and methods for making or developing same

Liquid compositions capable of foaming and including active agents, and methods for making or developing same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/12 A61K-009/00 A61K-031/167 A61K-031/192 A61K-031/196 A61K-031/4174 A61K-031/573 A61K-031/7048
출원번호	US-0633929 (2015-02-27)
등록번호	US-9693956 (2017-07-04)
우선권정보	DE-10 2009 034 603 (2009-07-24)
발명자 / 주소	Seigfried, Bernd G.
출원인 / 주소	MIKA Pharma GmbH
대리인 / 주소	Goodwin Procter LLP
인용정보	피인용 횟수 : 0 인용 특허 : 27

초록 ▼

A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.

대표청구항 ▼

1. A foam applicator comprising: a liquid composition for topical use, wherein the liquid composition comprises:(a) between 4 wt. % and 15 wt. % of a phospholipid foaming agent comprising 80 wt. % ±10 wt. % phosphatidyl choline and 3 wt. % ±3 wt. % lysophosphatidyl choline on a dry weight basis;(b) 5 wt. % to 15 wt. % isopropanol,(c) 5 wt. % to 15 wt. % propylene glycol; and(d) a pharmaceutically acceptable active agent; wherein the foam applicator mechanically foams the liquid composition without an additional propellant; andwherein upon mechanical foaming by the foam applicator of 250 ml of the liquid composition a foam is produced with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement; and wherein the foam has a density of about 0.05 g/ml to about 0.8 g/ml. 2. The foam applicator of claim 1, wherein the foam volume of the produced foam is about 600 ml to about 1200 ml. 3. The foam applicator of claim 1, wherein the produced foam has a density of about 0.15 g/ml to about 0.4 g/ml. 4. The foam applicator of claim 1, wherein the phospholipid foaming agent comprises at most 10 wt. % of phosphatidic acid and at most 10 wt. % of phosphatidyl ethanolamine. 5. The foam applicator of claim 1, wherein the liquid composition further comprises EDTA. 6. The foam applicator of claim 1, wherein the liquid composition comprises 15 wt. % propylene glycol. 7. The foam applicator of claim 1, wherein the liquid composition comprises at least one topical anesthetic as the active agent, in a concentration between 3 wt. % and 15 wt. %. 8. The foam applicator of claim 1, where the liquid composition comprises an immunomdulator as the active agent in a concentration between 0.03 wt. % and 0.1 wt. %. 9. The foam applicator of claim 1, wherein the active agent is selected from the group consisting of local anesthetics, antimycotics, antibiotics, analgesics, nonsteroidal antirrheumatics, nonsteroidal anti-inflammatories, corticoids, immune modulators and salts thereof. 10. The foam applicator of claim 9, wherein the liquid composition comprises between 0.1 wt. % and 20 wt. % of at least one analgesic as the active agent. 11. The foam applicator of claim 9, wherein the liquid composition comprises between 0.01 wt. % and 10 wt. % of at least one antimycotic as the active agent. 12. The foam applicator of claim 9, wherein the liquid composition comprises at least one corticoid active agent in a concentration between 0.1 wt. % and 5 wt. %.

이 특허에 인용된 특허 (27)

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Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
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Leigh, Steven; Leigh, Mathew L. S., Pharmaceutical compositions and their use.
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