초록 ▼

An infusion assembly is provided. Such an infusion assembly includes a first infusion body and a first nozzle operably engaged with the first infusion body. A first plunger is configured to translate longitudinally within the first infusion body for dispensing a first substance out of the first infu

An infusion assembly is provided. Such an infusion assembly includes a first infusion body and a first nozzle operably engaged with the first infusion body. A first plunger is configured to translate longitudinally within the first infusion body for dispensing a first substance out of the first infusion body through the first nozzle. The plunger has a translating member and a stopper piston separable and removable from the translating member. Once separated, the stopper piston is capable of receiving a second nozzle of a second infusion body such that the first substance, along with a second substance in the second infusion body, are capable of being sequentially administered to a target site. An associated method and kit are also provided.

대표청구항 ▼

1. An infusion assembly, comprising: a first infusion body having an end wall;a first nozzle operably engaged with the first infusion body proximate to the end wall;a first plunger configured to translate longitudinally within the first infusion body for dispensing a first substance out of the first

1. An infusion assembly, comprising: a first infusion body having an end wall;a first nozzle operably engaged with the first infusion body proximate to the end wall;a first plunger configured to translate longitudinally within the first infusion body for dispensing a first substance out of the first infusion body through the first nozzle, the first plunger comprising a translating member and a stopper piston separable and removable from the translating member, the stopper piston defining a cavity and being configured to facilitate a two-stage seating arrangement;a second infusion body configured to be received within the first infusion body;a second nozzle operably engaged with the second infusion body;a second plunger configured to translate longitudinally within the second infusion body for dispensing a second substance out of the second infusion body through the second nozzle; andwherein the stopper piston, once separated from the translating member, is configured to receive the second nozzle in a first seating position within the cavity such that the second plunger is capable of advancing the stopper piston to dispense the first substance from the first infusion body, and the second plunger is capable of being further advanced to cause the stopper piston to abut the end wall and to move the second nozzle into a second seating position within the cavity so as to extend the second nozzle through the stopper piston such that the second substance contained in the second infusion body is capable of being dispensed through the second nozzle and the first nozzle. 2. An infusion assembly according to claim 1, wherein the stopper piston has a penetrable portion capable of being pierced so as to allow the second nozzle to extend through the penetrable portion when advanced to the second seating position. 3. An infusion assembly according to claim 2, wherein the penetrable portion comprises a slit. 4. An infusion assembly according to claim 1, wherein the translating member comprises a shaft having first and second ends, the first end having a guide surface configured to facilitate advancement of the first plunger, and the second end having a tip portion configured to conform to the cavity so as to be received therein. 5. A method of sequentially delivering a first and second substance to a target site, the method comprising: providing a first infusion device having a first infusion body containing a first substance;providing a second infusion device having a second infusion body containing a second substance;positioning at least a portion of the second infusion device within the first infusion body;engaging a second nozzle of the second infusion device with a stopper piston in a first seating position such that the second nozzle extends at least partially therethrough;advancing a plunger associated with the second infusion device such that the stopper piston interacts with the first substance so as to expel the first substance from the first infusion body through a first nozzle of the first infusion device; andadvancing the plunger to move the second nozzle into a second seating position with respect to the stopper piston so as to pierce a penetrable portion of the stopper piston with the second nozzle such that the second nozzle extends therethrough and to expel the second substance from the second infusion body through the second nozzle and then through the first nozzle to a target site. 6. A method according to claim 5, wherein positioning at least a portion of the second infusion device within the first infusion body comprises removing an additional plunger associated with the first infusion device therefrom such that the second infusion body is capable of being received within the first infusion body. 7. A method according to claim 5, wherein the step of piercing a penetrable portion of the stopper piston further comprises piercing a penetrable portion comprising a slit. 8. A method according to claim 5, wherein the first substance is an antimicrobial formulation and the second substance is a sealant formulation. 9. A method according to claim 5, wherein the first substance is less viscous than the second substance. 10. A kit, comprising: a first infusion device having a first substance and a first plunger, the first infusion device being configured to independently deliver the first substance to a target site via actuation of the first plunger;a second infusion device having a second substance, a second plunger, and a nozzle, the second infusion device being configured to independently deliver the second substance to the target site via actuation of the second plunger; anda stopper piston configured to be securely seated on the nozzle such that the second infusion device is capable of acting as a plunger for the first infusion device when the first plunger is removed, so as to expel the first substance from the first infusion device, the stopper piston having a penetrable portion, and the stopper piston defining a cavity that provides a two-stage seating arrangement to facilitate movement of the nozzle from a first seating position to a second seating position within the cavity for piercing the penetrable portion. 11. A kit according to claim 10, wherein the penetrable portion comprises a slit. 12. An infusion assembly, comprising: a first infusion device having a first nozzle disposed proximate to an end wall, the first infusion device having a stopper piston defining a cavity and being configured to facilitate a two-stage seating arrangement;a second infusion device configured to be received within the first infusion device, the second infusion device having a second nozzle and a plunger configured to translate longitudinally for dispensing a second substance out of the second nozzle; andwherein the stopper piston is configured to receive the second nozzle in a first seating position within the cavity such that the plunger is capable of advancing the stopper piston to dispense a first substance from the first infusion device, and the plunger is capable of being further advanced to cause the stopper piston to abut the end wall and to move the second nozzle into a second seating position within the cavity so as to extend the second nozzle through the stopper piston such that the second substance contained in the second infusion device is capable of being dispensed through the second nozzle and the first nozzle. 13. An infusion assembly according to claim 12, wherein the stopper piston has a penetrable portion capable of being pierced so as to allow the second nozzle to extend through the penetrable portion when advanced to the second seating position. 14. An infusion assembly according to claim 13, wherein the penetrable portion comprises a slit.