[특허]Automated system for isolating, amplifying and detecting a target nucleic acid sequence

Automated system for isolating, amplifying and detecting a target nucleic acid sequence 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01L-003/00 C12M-001/00 G01N-035/00 G01N-035/02 G01N-035/10 G01N-035/04
출원번호	US-0551830 (2012-07-18)
등록번호	US-9696328 (2017-07-04)
발명자 / 주소	Hansen, Timothy R. Collis, Matthew P. Thomas, Bradley S. Fort, Thomas L.
출원인 / 주소	Becton, Dickinson and Company
대리인 / 주소	Botos Churchill IP Law LLP
인용정보	피인용 횟수 : 0 인용 특허 : 167

초록 ▼

A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.

대표청구항 ▼

1. A method for processing a component of interest contained in a sample, comprising: receiving at least one tube containing a sample in a sample rack;automatically transferring the sample from the tube to an extraction device comprising a tube using a selectively compliant articulated robot arm (SCARA);operating the extraction device to extract said component of interest from the sample while the sample is disposed in the extraction device tube;automatically transferring the extracted component of interest from the extraction tube in the extraction device to a primer well and from a primer well to an amplification/reader well disposed in an amplification plate, wherein the automatically transferring includes operating the SCARA to perform said transferring;automatically picking up a plate seal gripper tool and sealing the amplification plate using the SCARA;moving the amplification plate to a detector wherein the amplification plate is moved using the SCARA; andoperating a detector to detect for the presence of said component of interest extracted by said extraction device. 2. A method as claimed in claim 1, wherein: the component of interest includes a nucleic acid;the extraction device operating step extracts the nucleic acid from the sample; andthe detection device operating step detects the presence of the extracted nucleic acid. 3. A method as claimed in claim 1, wherein: the extracted component of interest includes a nucleic acid; andthe detection device operating step includes amplifying the nucleic acid. 4. A method as claimed in claim 3, wherein: the amplifying includes heating the nucleic acid. 5. A method as claimed in claim 1, wherein: the extraction device operating step performs non-specific capture of the component of interest to extract the component of interest from the sample. 6. The method as claimed in claim 5, wherein the component of interest is a nucleic acid. 7. The method as claimed in claim 5, wherein the component of interest is a protein. 8. The method as claimed in claim 1, wherein the extraction device and detection device are integrated as a single unit. 9. The method as claimed in claim 1, further comprising: receiving at least one container containing the sample in a sample rack. 10. A method for automatically extracting nucleic acid from a sample, comprising: operating a selectively compliant articulated robot arm (SCARA);extracting the nucleic acid from the sample with an extractor comprising a tube configured to receive the sample from a sample tube, wherein operating said SCARA comprises moving the sample from the sample tube to the extractor tube using a first pipette tip retrieved by the SCARA;transferring the extracted nucleic acid from the extractor tube to a well in an amplification plate using the SCARA, wherein a second pipette tip retrieved by the SCARA is used for the transfer;sealing the amplification plate using the SCARA wherein the SCARA picks up a plate seal and places the plate seal on the amplification plate;andtransferring the amplification plate into a detector device using the SCARA. 11. A method for automatically extracting a target nucleic acid from a sample, comprising: operating an extractor comprising a tube to perform non-specific capture on the target nucleic acid to extract the nucleic acid from the sample without separating the target nucleic acid from non-target nucleic acid that may exist in the sample;operating an amplifier to amplify the extracted nucleic acid; andautomatically transferring the extracted nucleic acid from the extractor tube to sample wells in an amplifier plate;automatically sealing the amplifier plate;automatically transferring the amplifier plate to a detector, where the automatically transferring steps and the automatically sealing step all use a selectively compliant articulated robot arm (SCARA) to perform the steps. 12. A method as claimed in claim 11, further comprising: automatically transferring the sample from a container to said extractor tube. 13. A method as claimed in claim 11, further comprising: automatically transferring fluid to the extractor to assist the extractor in extracting the target nucleic acid. 14. An automated process for isolating and amplifying a target nucleic acid sequence that may be present in a sample, said process comprising: automatically separating the target sequence from the fluid sample at a separation station by performing non-specific binding on the target sequence without the need to physically separate the target sequence from any non-target sequence that may exist in the sample prior to separating;automatically transporting the separated target sequence from the separation station to an amplifying incubation station using a selectively compliant articulated robot arm (SCARA);automatically picking up a plate seal gripper tool and sealing the amplification plate using the SCARA; andautomatically transporting an amplification plate having wells containing the separated target sequence from the amplifying incubation station to a detection station using the SCARA.

이 특허에 인용된 특허 (167)

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Claypool Mark P. (Horseheads NY) Battersby Patrick T. (Elmira NY), Optical inspection of transparent layers.
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Klein Gerald L. (Edmonds WA) Russell Gene D. (Seattle WA) Day Steven R. (Bothell WA) Liebermann Jerrold D. (Seattle WA), Photodensitometer for minimizing the refractive effects of a fluid sample.
상세보기
Hiroshi Tamura (Tokyo JPX) Shigenori Tanaka (Tokyo JPX), Photometer.
상세보기
Gerlier Jean-Pierre (Saint-Maur-les-Fosses FRX) Augier Jacques (Paris FRX), Photometer with automatic test sample selection, scanning and analysis system.
상세보기
Banno Taiichi (Hachioji JPX) Hijikata Kazuo (Hachioji JPX) Takekawa Hiroshi (Sagamihara JPX), Photometering apparatus for use in chemical analyzer.
상세보기
Smith Harry F. (7 Fern Lake Newtown CT 06470), Photometric apparatus for multiwell plates having a positionable lens assembly.
상세보기
Bowley Alan R. (Inverness GB6), Photometric reading device for serological analysis.
상세보기
Fatches Keith R. (6 Crewe St. Bardwell Park ; New South Wales ; 2207 AUX), Pipette and filter combination.
상세보기
Moulton Tom, Pipette tip and filter for accurate sampling and prevention of contamination.
상세보기
Kawanabe Junichi (Mitaka JPX) Takeda Masaaki (Mitaka JPX) Katagi Hitomi (Mitaka JPX) Kato Yuko (Mitaka IL JPX) Pelletier Brent A. (Mundelein IL), Pipetting apparatus.
상세보기
Takeda Masaaki (Mitaka JPX) Katagi Hitomi (Mitaka JPX) Kato Yuko (Mitaka JPX) Kawanabe Junichi (Mitaka JPX), Pipetting apparatus with clot detection.
상세보기
Kimura Akira (Tokyo JPX) Watanabe Tadashi (Kanagawa JPX) Inoue Tsuyoshi (Kanagawa JPX) Nakamachi Keiichi (Saitama JPX), Pipetting device and method therefore.
상세보기
Reinicke, Robert H., Precision medication dispensing system and method.
상세보기
Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
상세보기
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
상세보기
Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
상세보기
Arnold ; Jr. Lyle J. (San Diego CA) Waldrop ; III Alexander A. (San Diego CA) Hammond Philip W. (San Diego CA), Proteted chemiluminescent labels.
상세보기
Holen, James T.; Hicaro, Jr., Enrique; Putterman, Caryn G.; Huang, Tung-Ming; Merkh, Carl W., Reaction cartridge and carousel for biological sample analyzer.
상세보기
Valenta Robert J. (Berkeley IL), Reduced background scintillation counting.
상세보기
Warner Brian D. (Martinez CA) Nordell Benjamin T. (Belmont CA) Richardson Bruce J. (Los Gatos CA) El-Hage Amer (Menlo Park CA), Releasable multiwell plate cover.
상세보기
Fujiwara Toshihide (Fuchu JPX) Kaneko Nobutaka (Hachiouji JPX), Sample detector.
상세보기
Brentz Charles W. (Evanston IL), Sample pipetting method.
상세보기
Uchida Makoto (Ootawara JPX), Sample-sucking condition checking method and system.
상세보기
VanCauter Gustaaf C. (Middletown CT) Osten Donald E. (Bolingbrook IL) Tomisek John D. (Lombard IL), Scintillation counting system for in-situ measurement of radioactive samples in a multiple-well plate.
상세보기
Burg James L. (Foster City CA) Pouletty Philippe J. (Menlo Park CA) Boothroyd John C. (Palo Alto CA), Selective amplification of target polynucleotide sequences.
상세보기
Suovaniemi Osmo A. (Helsinki FIX), Set of cuvettes.
상세보기
Chow Calvin Y. H. (Portola Valley CA) Humphries Gillian M. (Los Altos CA) Kung Viola T. (Menlo Park CA) Lacy Michael M. (Ben Lomand CA), Single source multi-site photometric measurement system.
상세보기
Chow Calvin Y. H. (Portola Valley CA) Humphries Gillian M. (Los Altos CA) Kung Viola T. (Menlo Park CA) Lacy Michael M. (Ben Lomand CA) Hayter Paul (Los Altos CA), Single source multi-site photometric measurement system.
상세보기
Miller ; Thomas R., Slurry control system.
상세보기
McConnell Harden M. (Stanford CA) Briggs Jonathan (Palo Alto CA) Parce John W. (Winston-Salem NC), Solid-state optical assay imaging apparatus.
상세보기
Klinkhammer Gary (Corvallis OR), Spectrophotometer for chemical analyses of fluids.
상세보기
Schulz Isidore (Clarendon Hills IL), Storage and indexing mechanism for multiple sample containers.
상세보기
Mark C. Bach ; Daniel Bay ; Michael K. Carter ; John M. Clemens ; Daniel G. Dahlke ; Charles M. Galitz ; Robert C. Gray ; Folim Halaka ; Steve Herchenbach ; Ronald E. Kukla ; Curtis J. Pepe, Structure and method for performing a determination of an item of interest in a sample.
상세보기
Mullis Kary B. (LaJolla CA) Johnson Larry (San Jose CA) Leath Richard A. (Berkley CA) Wennberg Timothy J. (Mariposa CA) Mezei Louis M. (Madison WI) Widunas Joseph T. (Freemont CA), System for automated performance of the polymerase chain reaction.
상세보기
Atake Minoru (579-6 ; Ohoiso ; Ohoisa-machi Kanagawa-Ken JPX), System for measuring liquid.
상세보기
DeWitt Sheila H. H. ; Kiely John S. ; Pavia Michael R. ; Schroeder Mel C. ; Stankovic Charles J., System for multiple simultaneous synthesis.
상세보기
Reichler Allen S. (Owing Mills MD) Antol David J. (Baldwin MD) Lamos Michael L. (Westminster MD) Bourdelle Peter A. (Glen Rock PA) Hildebrand Scott D. (Red Lion PA), System for nucleic acid based diagnostic assay.
상세보기
Collins Mark L., Target and background capture methods and apparatus for affinity assays.
상세보기
Collins Mark L. ; Halbert Donald N. ; King Walter ; Lawrie Jonathan M., Target and background capture methods with amplification for affinity assays.
상세보기
Merkh Carl W. (Lindenhurst IL) Defreese James D. (Wildwood IL) Durley ; III ; deceased Benton A. (late of Antioch IL by Robert W. Durley ; executrix), Test array for performing assays.
상세보기
Durley ; III Benton A. (Antioch IL) Defreese James D. (Wildwood IL) Merkh Carl W. (Lindenhurst IL), Test card for performing assays.
상세보기
Forrest Gordon C. (Ingatestone GB2), Test-tube assembly for immunoassays utilizing magnetically attractable particles.
상세보기
Suovaniemi Osmo A. (Helsinki FIX) Ekholm Pertti (Helsinki FIX) Kaukanen Esko (Espoo FIX), Transfer device for analysis equipment.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Automated system for isolating, amplifying and detecting a target nucleic acid sequence 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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연합인증

Automated system for isolating, amplifying and detecting a target nucleic acid sequence 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (167)

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IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

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