로그인시 본인확인과정이 필요할 수 있습니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기
| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0505683 (2010-11-05) |
| 등록번호 | US-9700650 (2017-07-11) |
| 국제출원번호 | PCT/US2010/055714 (2010-11-05) |
| §371/§102 date | 20120814 (20120814) |
| 국제공개번호 | WO2011/057131 (2011-05-12) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 623 |
Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for u
Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
1. A hydrogel composition, comprising carboxymethylchitosan having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, an electrophilic group, and at least two nucleophilic groups, wherein carboxymethylchitosan is soluble in an aqueous solution;a multif
1. A hydrogel composition, comprising carboxymethylchitosan having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, an electrophilic group, and at least two nucleophilic groups, wherein carboxymethylchitosan is soluble in an aqueous solution;a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups; anda multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis andwherein the hydrogel composition comprises: a covalent bond between carboxymethylchitosan and the multifunctional multi-armed polyethylene glycol polymer;a covalent bond between carboxymethylchitosan and the multifunctional multi-armed crosslinker anda covalent bond between the multifunctional multi-armed polyethylene glycol polymer and the multifunctional multi-armed crosslinker. 2. The composition of claim 1, wherein carboxymethylchitosan is present in the composition from 0.5% to 10% by mass. 3. The composition of claim 1, further comprising one or more of a thickening agent, filler, a foaming agent, a biologically active agent, a pharmaceutically active agent, a visualization agent, or a radiopaque agent. 4. The composition of claim 3, wherein the composition comprises a biologically active agent. 5. The composition of claim 4, wherein the biologically active agent is a plasma protein, hormone, enzyme, antiseptic agent, antibiotic, antineoplastic agent, antifungal agent, antiviral agent, anti-inflammatory agent, human or non-human growth factor, anesthetic, cell suspension, cytotoxins, cell proliferation inhibitors, fibrin, fibrinogen, collagen or biomimetic. 6. The composition of claim 3, wherein the composition comprises a filler selected from the group consisting of hydroxyapatite, fibrous silk, carbon fiber, bone chips and a mesh of polyglycolic acid. 7. The composition of claim 3, wherein the composition comprises a visualization agent. 8. The composition of claim 3, wherein the composition comprises a radiopaque agent. 9. A hydrogel composition, comprising: dicarboxyl chitosan having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, an electrophilic group, and at least two nucleophilic groups, wherein the dicarboxyl chitosan is soluble in an aqueous solution;a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups; anda multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis andwherein the hydrogel composition comprises: a covalent bond between dicarboxyl chitosan and the multifunctional multi-armed polyethylene glycol polymer;a covalent bond between dicarboxyl chitosan and the multifunctional multi-armed crosslinker anda covalent bond between the multifunctional multi-armed polyethylene glycol polymer and the multifunctional multi-armed crosslinker. 10. The composition of claim 9, wherein dicarboxyl chitosan is present in the composition from 0.5% to 10% by mass. 11. The composition of claim 9, further comprising one or more of a thickening agent, filler, a foaming agent, a biologically active agent, a pharmaceutically active agent, a visualization agent, or a radiopaque agent. 12. The composition of claim 11, wherein the composition comprises a biologically active agent. 13. The composition of claim 12, wherein the biologically active agent is a plasma protein, hormone, enzyme, antiseptic agent, antibiotic, antineoplastic agent, antifungal agent, antiviral agent, anti-inflammatory agent, human or non-human growth factor, anesthetic, cell suspension, cytotoxins, cell proliferation inhibitors, fibrin, fibrinogen, collagen or biomimetic. 14. The composition of claim 11, wherein the composition comprises a filler selected from the group consisting of hydroxyapatite, fibrous silk, carbon fiber, bone chips and a mesh of polyglycolic acid. 15. The composition of claim 11, wherein the composition comprises a visualization agent. 16. The composition of claim 11, wherein the composition comprises a radiopaque agent.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.