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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0577610 (2014-12-19) |
| 등록번호 | US-9701940 (2017-07-11) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 574 |
A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage.
A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
1. An implant comprising: a collagen scaffold comprising pores, having a basal surface and an apical surface each with openings to the pores, wherein at least 85% of the pores in the scaffold are vertically oriented; anda suspension of chondrocytes seeded into the scaffold. 2. The implant of claim 1
1. An implant comprising: a collagen scaffold comprising pores, having a basal surface and an apical surface each with openings to the pores, wherein at least 85% of the pores in the scaffold are vertically oriented; anda suspension of chondrocytes seeded into the scaffold. 2. The implant of claim 1, wherein at least 85% of the openings of the apical surface have a diameter of 200±100 micrometers. 3. The implant of claim 2, wherein the apical surface has a pore density of 25±10 pores per mm2. 4. The implant of claim 1, wherein at least 85% of the openings of the basal surface have a diameter of 200±100 micrometers. 5. The implant of claim 4, wherein the basal surface has a pore density of 25±10 pores per mm2. 6. The implant of claim 1, wherein at least 95% of the basal and apical openings have diameters of 200±100 micrometers. 7. The implant of claim 6, wherein at least 98% of said basal and apical openings have diameters of 200±100 micrometers. 8. The implant of claim 1, wherein the collagen scaffold comprises Type I collagen, Type II collagen, Type IV collagen or a combination thereof. 9. The implant of claim 1, wherein the scaffold is formed by polymerizing a collagen solution in the presence of ammonia vapor. 10. The implant of claim 9, wherein the collagen solution is polymerized at a reduced pressure. 11. The implant of claim 10, wherein the collagen solution is polymerized at between 3 Torr and 10 Torr of pressure. 12. The implant of claim 9, wherein the collagen solution comprises between 4 mg/ml and 8 mg/ml of Type I collagen in aqueous solution. 13. The implant of claim 12, wherein the aqueous solution is acidic. 14. The implant of claim 12, wherein the collagen solution comprises a non-ionic surfactant. 15. The implant of claim 14, wherein the non-ionic surfactant comprises a polyoxyethylene-polyoxypropylene block copolymer. 16. The implant of claim 9, further comprising freeze-drying the scaffold prior to seeding the scaffold with chondrocytes. 17. The implant of claim 1, wherein the chondrocytes are seeded as a suspension of chondrocytes in a collagen solution. 18. The implant of claim 17, wherein the collagen chondrocyte suspension has a concentration of 1 million to 12 million chondrocyte cells per mL of collagen solution. 19. The implant of claim 1, wherein the chondrocytes comprise human articular chondrocytes.
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