[특허]Apparatus and method for maintaining and/or restoring viability of organs

Apparatus and method for maintaining and/or restoring viability of organs 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A01N-001/02
출원번호	US-0784326 (2013-03-04)
등록번호	US-9706769 (2017-07-18)
발명자 / 주소	Taylor, Michael Brassil, John
출원인 / 주소	ORGAN RECOVERY SYSTEMS, INC
대리인 / 주소	Oliff PLC
인용정보	피인용 횟수 : 0 인용 특허 : 33

초록 ▼

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.

대표청구항 ▼

1. A method for perfusing an organ, comprising: placing an organ on an organ supporting surface within a portable housing, wherein the organ is capable of being in fluid contact with a first medical fluid and/or a second medical fluid;perfusing the organ with the first medical fluid through at least one blood vessel of the organ; andadding an enzyme to the second medical fluid and perfusing the organ with the second medical fluid through at least one blood vessel of the organ and at least one non-blood vessel duct of the organ, wherein substantially all of the first medical fluid is removed from the portable housing before perfusing the organ with the second medical fluid containing the enzyme; wherein the organ is perfused at while being maintained at a hypothermic temperature, andthe organ is perfused with the first medical fluid and the second medical fluid without removal of the organ from the portable housing. 2. The method according to claim 1, wherein the first and second medical fluids do not mix. 3. The method according to claim 1, wherein the organ is a pancreas. 4. The method according to claim 1, wherein the organ supporting surface within the portable housing is optically clear organ supporting surface. 5. The method according to claim 1, wherein the portable housing is part of a perfusion system that includes one or more tubes, a cassette, a filter, and a bubble trap, which are in fluid connection with the organ, and the first medical fluid is removed from the perfusion system before beginning perfusion with the second medical fluid containing the enzyme. 6. The method according to claim 1, wherein the hypothermic temperature is in a range of from about 4 to about 10° C. 7. The method according to claim 1, wherein the organ supporting surface is comprised in an organ cassette for holding the organ; and the portable housing includes a compartment structured to receive and support the organ cassette. 8. The method according to claim 7, wherein the organ cassette is configured to hold the organ independently from the portable housing. 9. The method according to claim 8, wherein the organ cassette is configured to be received by the portable housing, without jeopardizing sterility of interior of the organ cassette, for transport of the organ. 10. The method according to claim 9, wherein the organ cassette is configured to be removed from the portable housing without jeopardizing sterility of the interior of the organ cassette and without removal of the organ from the organ cassette. 11. The method according to claim 10, wherein the organ cassette is configured to allow storage and transport of the organ without removal of the organ from the organ cassette.

이 특허에 인용된 특허 (33)

Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
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Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
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Jost Leonora I. (21 Rosewood Cir. ; Unit 1 Kennebunk ME 04043), Biological support system container.
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Klatz Ronald M. (Chicago IL) Goldman Robert M. (Chicago IL), Brain resuscitation and organ preservation device and method for performing the same.
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Klatz Ronald M. (Chicago IL) Goldman Robert M. (Chicago IL), Brain resuscitation and organ preservation device and method for performing the same.
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Klatz Ronald M. (1510 Montana St. Chicago IL 60614) Goldman Robert M. (2434 N. Greenview Chicago IL 60614), Brain resuscitation device and method for performing the same.
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Klatz Ronald M. (1510 Montana St. Chicago IL 60614) Goldman Robert M. (2434 N. Greenview Chicago IL 60614), Brain resuscitation device and method for performing the same.
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Fisher Robyn (15555 N. Oracle Rd. Tucson AZ 85737) Brendel Klaus (3231 N. Manor Dr. Tucson AZ 85715), Cold and cryo-preservation methods for human tissue slices.
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O\Dell Bobby J. (San Antonio TX) Bunegin Leonid (San Antonio TX), Combined perfusion and oxygenation apparatus.
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O\Dell Bobby J. (San Antonio TX), Combined perfusion and oxygenation organ preservation apparatus.
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Hassanein Waleed H., Compositions, methods and devices for maintaining an organ.
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Fahy Gregory M. (Gaithersburg MD), Computer controlled cryoprotectant perfusion apparatus.
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Bacchi Bernard (Garches FRX) Marchot Patrick (Colombes FRX) Mauriat Philippe (Vanves FRX) Touati Gilles (Tours FRX) Pouard Philippe (Clamart FRX) Magnard Alain (Longpont sur Orge FRX) Thomas Philippe, Controlled-environment medical container.
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Owen Donald R., Cryogenic fluid heat exchanger method and apparatus.
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Brasile Lauren (Albany NY), Diagnostic methods for monitoring functional charcteristics of an organ intended for transplantation.
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Osgood Richard W., Donor kidney viability test for improved preservation.
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Wikman-Coffelt Joan (Davis CA), Long-term preservation of organs for transplantation.
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Brasile Lauren (Albany NY) Clarke Jolene (Ballston Spa NY), Method and solution for organ preservation comprising retinal-derived growth factor, cyclodextrin, mucopolysaccharide an.
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O\Dell Bobby J. (San Antonio TX) Bunegin Leonid (San Antonio TX), Method for hypothermic preservation of living tissue.
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Taylor,Michael John; Brassil,John, Method for perfusing an organ and for isolating cells from the organ.
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Taylor, Michael John; Brassil, John, Method for perfusing an organ for isolating cells from the organ.
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Fahy Gregory M. (Gaithersburg MD) Khirabadi Bijan S. (Rockville MD), Method for preserving organs for transplantation by vitrification.
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Wong Grace H. W. (South San Francisco CA) Goeddel David V. (Hillsburough CA), Method for protection of ischemic tissues using tumor nerosis factor.
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Brasile Lauren (61 Meadow La. Albany NY 12208), Method for treating and rendering grafts nonthrombogenic and substantially nonimmunogenic using an extracellular matrix.
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Sadri Fereydoon (Redmond WA), Organ perfusion device.
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McGhee Samuel C. (P.O. Box 1953 Sugar Land TX 77478) McGhee C. Lester (P.O. Box 1953 Sugar Land TX 77478), Organ preservation apparatus.
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Safar Peter (Pittsburgh PA) Stezoski S. William (Pittsburgh PA) Klain Miroslav (Pittsburgh PA), Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method.
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Fahy Gregory M. (Gaithersburg MD), Portable device for preserving organs by static storage or perfusion.
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Brasile Lauren (Albany NY) Clarke Jolene (Ballston Spa NY), Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprisi.
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Manning James E. (Chapel Hill NC), Selective aortic arch perfusion.
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Manning James E. (Chapel Hill NC), Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest.
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Brasile Lauren, Solution and process for resuscitation and preparation of ischemically damaged tissue.
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Michael J. Taylor, System for organ and tissue preservation and hypothermic blood substitution.
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