Ventilator aerosol delivery system with transition adapter for introducing carrier gas
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-011/00
A61M-015/00
A61M-016/10
A61M-016/14
B05B-007/00
A61M-011/02
A61M-016/00
A61M-011/04
A61M-011/06
A61M-016/08
B05B-007/04
A61M-015/02
출원번호
US-0843172
(2013-03-15)
등록번호
US-9713687
(2017-07-25)
발명자
/ 주소
Leamon, James
Gregory, Timothy J.
Mazela, Jan
Henderson, Christopher
출원인 / 주소
Philip Morris USA Inc.
대리인 / 주소
Buchanan Ingersoll & Rooney PC
인용정보
피인용 횟수 :
0인용 특허 :
61
초록▼
A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for r
A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector.
대표청구항▼
1. An aerosol transition adapter for delivering an aerosolized active agent to a patient receiving ventilation support, the aerosol transition adapter comprising: a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a sourc
1. An aerosol transition adapter for delivering an aerosolized active agent to a patient receiving ventilation support, the aerosol transition adapter comprising: a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a source of aerosol comprising an aerosolized active agent and the distal end having an exit port, the housing having a length between the distal end and the proximal end;a carrier gas connection port configured to receive a carrier gas from a positive pressure gas source, which is in communication with a plurality of carrier gas exit ports, and wherein the plurality of carrier gas exit ports are arranged adjacent to the aerosol passage in a pattern that at least partially encircles a flow of aerosol from the aerosol passage;a carrier gas conduit connected to the carrier gas connection port, wherein the carrier gas conduit is in communication with the positive pressure gas source; andan inner cavity, which is adapted to receive the aerosol from the aerosol passage and the carrier gas from the plurality of carrier gas exit ports and to direct streams of carrier gas to at least partially encircle and flow in parallel with a main direction of a flow of the aerosol along the length of the housing toward the exit port, the inner cavity having a proximal portion having a conical inner wall, which extends outward to an inner wall of a distal portion of the inner cavity, and wherein the plurality of carrier gas exit ports are located on the conical inner wall. 2. The adapter of claim 1, wherein the plurality of carrier gas exit ports are positioned on the conical inner wall at an equidistance from a center of the aerosol passage. 3. The adapter of claim 1, wherein the housing includes a cylindrical proximal portion and a cylindrical distal portion, and wherein the cylindrical proximal portion includes the carrier gas connection port configured to receive the carrier gas from the positive pressure gas source. 4. The adapter of claim 3, wherein an outer diameter of the cylindrical proximal portion is less than an outer diameter of the cylindrical distal portion. 5. The adapter of claim 1, wherein the carrier gas connection port for receiving the carrier gas from the gas source includes at least one gas entry port for receiving the carrier gas, the at least one gas entry port directing a stream of carrier gas to the plurality of gas exit ports. 6. The adapter of claim 5, wherein the at least one gas entry port comprises at least three gas entry ports, and the plurality of the carrier gas exit ports comprises at least three gas exit ports with a corresponding gas exit port for each of the gas entry ports. 7. The adapter of claim 6, wherein the at least three gas exit ports are equally spaced around the aerosol passage. 8. The adapter of claim 1, wherein each of the plurality of carrier gas exit ports is approximately 1 to 10 millimeters in diameter and located at approximately a 3 to 20 millimeter radius from a central axis of the aerosol passage. 9. The adapter of claim 1, wherein the exit port of the transition adapter has an inner diameter of approximately 22 mm to approximately 50 mm. 10. The adapter of claim 1, comprising: a flange, which is attached to the proximal end of the housing. 11. The adapter of claim 10, comprising: a cavity within the flange, which is configured to be attachable to the source of aerosol. 12. An aerosol delivery system, comprising: an aerosol generator for producing an aerosol;a positive pressure generator for producing a pressurized ventilation gas;a splitter for splitting the pressurized ventilation gas into the carrier gas and a ventilation gas and a conduit from the positive pressure generator to the splitter;an aerosol transition adapter according to claim 1 and arranged to combine the aerosol produced by the aerosol generator with the carrier gas from the splitter, and which forms an entrained aerosol;an aerosol delivery connector having a port for receiving the entrained aerosol, a port for entry of the ventilation gas, a patient-aerosol interface port for delivering the entrained aerosol from the aerosol transition adapter and the ventilation gas from the splitter to a patient, and a port for exit of expiration gas from the patient; anda patient interface for receiving the entrained aerosol and the ventilation gas from the aerosol delivery connector. 13. The system of claim 12, further comprising a conduit for delivering the entrained aerosol and the ventilation gas from the patient-aerosol interface port to the patient interface. 14. The system of claim 12, further comprising a humidifier located between the splitter and the aerosol delivery connector for humidifying the ventilation gas before the ventilation gas enters the aerosol delivery connector. 15. The system of claim 14, wherein a ventilation flow tube connecting the splitter to the humidifier is a corrugated tubing having a diameter of approximately 10 to 12 millimeters in diameter with an approximately 15 millimeter conical end connector. 16. The system of claim 12, comprising: a fluid trap, which is located between the aerosol transition adapter and the aerosol delivery connector, and wherein the fluid trap is configured to entrap condensed liquid or liquid from the entrained aerosol. 17. The system of claim 16, wherein the fluid trap has a capacity of at least 60 milliliters, and an airway through the fluid trap is 15 to 22 millimeters in diameter. 18. The system of claim 17, wherein an aerosol tube connecting the fluid trap to the aerosol delivery connector is a corrugated tubing having a diameter of approximately 10 to 15 millimeters and a length of approximately 40 to 100 centimeters. 19. The system of claim 12, wherein the splitter for splitting the pressurized ventilation gas from the ventilator into the carrier and ventilation gas flows is a Wye or Tee fitting. 20. The system of claim 12, further comprising a source of liquid formulation containing a lung surfactant adapted for delivery as the aerosol to an infant's lungs, and wherein the source of liquid formulation is configured to be delivered to the aerosol generator. 21. The system of claim 12, wherein the ventilator is configured to supply an inspiratory flow of gas at a flow rate of about 1 to 10 L/min (liters per minute). 22. The system of claim 12, wherein the aerosol generator is at least one of a heated capillary aerosol generator, a nebulizer, a soft mist generator, a metered dose inhaler, a liquid dose instillation device, and/or a dry powder inhaler. 23. The system of claim 12, wherein the aerosol generator comprises more than one aerosol generator. 24. The system of claim 12, wherein the port for exit of expiration gas from the patient is connected to an expiratory tube, which is configured to deliver the expiration gas to the positive pressure generator after passing through a filter. 25. The system of claim 12, wherein the port for exit of expiration gas from the patient is connected to a source of back pressure. 26. The system of claim 25, wherein the source of back pressure is a water bath or reservoir. 27. The system of claim 12, wherein the splitter and the aerosol delivery connector each have a closure, which allows the system to deliver the ventilation gas to the patient without the aerosol. 28. An aerosol delivery system, comprising: an aerosol generator for producing an aerosol;a plurality of positive pressure generators, wherein at least one of the plurality of positive pressure generators is a positive pressure generator for producing a ventilation gas and at least one of the plurality of positive pressure generators is a positive pressure generator for producing a carrier gas;an aerosol transition adapter according to claim 1 and arranged to combine the aerosol produced by the aerosol generator with the carrier gas to form an entrained aerosol; anda patient interface for receiving the entrained aerosol and the ventilation gas. 29. A method of producing an entrained aerosol comprising: generating an aerosol;providing a source of carrier gas from a ventilator; andcombining the aerosol and the carrier gas in the aerosol transition adapter according to claim 1 by dividing the carrier gas into a plurality of streams of carrier gas, which are at least partially encircling and flowing in parallel with the aerosol to form an entrained aerosol. 30. The method of claim 29, comprising: splitting an inspiratory flow of gas from the ventilator into a carrier gas flow and a ventilation gas flow, wherein the carrier gas is combined with the aerosol in the aerosol transition adapter to form the entrained aerosol and the ventilation gas is delivered to an aerosol delivery connector, which receives the entrained aerosol and the ventilation gas for delivery to a patient. 31. The method of claim 29, further comprising delivering the entrained aerosol and the ventilation gas to the patient via a patient interface. 32. The method of claim 31, wherein, for a neonatal application, providing the inspiratory flow from the ventilator at a rate of approximately six liters per minute, and splitting the inspiratory flow rate from the ventilator into approximately three liters per minute into a carrier gas conduit and approximately three liters per minute into a ventilation gas conduit. 33. The method of claim 32, wherein the entrained aerosol enters the patient interface at approximately 35° C. to 39° C. 34. The method of claim 30, wherein the ventilation gas enters the aerosol delivery connector at approximately 35° C. to 39° C. 35. The method of claim 30, comprising: directing an exhaled gas from a patient to the ventilator such that a volume of an inspiratory gas originating from the ventilator is approximately equal to a volume of the exhaled gas directed to the ventilator. 36. The method of claim 30, wherein the step of generating the aerosol includes generating the aerosol with a heated capillary. 37. The method of claim 30, wherein the step of generating the aerosol includes generating the aerosol with a nebulizer, a soft mist generator, a metered dose inhaler, a liquid dose instillation device, or a dry powder inhaler. 38. The method of claim 30, wherein the ventilation gas is a humidified ventilation gas.
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