IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0739800
(2015-06-15)
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등록번호 |
US-9723830
(2017-08-08)
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발명자
/ 주소 |
- Steinman, Christopher P.
- Louis, Jeffrey S.
|
출원인 / 주소 |
- LIFELINE SCIENTIFIC, INC.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
9 |
초록
▼
A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an organ container configured to contain an organ, the filter integrated with an exterior portion of the o
A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an organ container configured to contain an organ, the filter integrated with an exterior portion of the organ container, and another filter. At least the filter integrated with an exterior portion of the organ container may be provided in a sterilized disposable kit.
대표청구항
▼
1. An apparatus for filtering perfusate, configured to be moved relative to an organ perfusion apparatus, and comprising: an organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate ma
1. An apparatus for filtering perfusate, configured to be moved relative to an organ perfusion apparatus, and comprising: an organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate may flow from the organ container to the organ perfusion apparatus during perfusion of the organ or tissue locatable in the basin; anda coarse filter covering the opening at the bottom of the basin so as to be configured to filter any of the perfusate that flows through the opening by preventing large particles in the perfusate from entering the opening, while ensuring a sufficient flow rate of the perfusate through the opening to maintain the perfusion of the organ or tissue,wherein the coarse filter is located so that, during the perfusion of the organ or tissue, the coarse filter is accessible to a practitioner by way of another opening in the organ container. 2. The filtering apparatus of claim 1, wherein the coarse filter constitutes an exterior portion of the organ container, the exterior portion at least partly forming the basin. 3. The filtering apparatus of claim 2, wherein the coarse filter is fitted into the opening at the bottom of the basin. 4. The filtering apparatus of claim 2, wherein the coarse filter is disposed in the exterior portion of the organ container such that an outer circumference or periphery of the coarse filter is between two surfaces of the exterior portion of the organ container. 5. The filtering apparatus of claim 1, wherein the coarse filter is detachable from the organ container. 6. The filtering apparatus of claim 1, wherein the coarse filter is a screen filter. 7. The filtering apparatus of claim 1, wherein the coarse filter has an average opening size of 100 microns to 10,000 microns. 8. The filtering apparatus of claim 7, wherein the coarse filter has an average opening size of 1,000 microns to 3,000 microns. 9. The filtering apparatus of claim 7, wherein the large particles are byproducts of the organ or tissue. 10. The filtering apparatus of claim 1, wherein (i) an organ-supporting surface configured to support the organ or tissue and (ii) the opening are on opposite sides of the coarse filter. 11. An apparatus, configured to be moved relative to an organ perfusion apparatus, and comprising: an organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate may flow from the organ container to the organ perfusion apparatus during perfusion of an organ or tissue locatable in the organ container;a recirculating perfusate flow path;a coarse filter that is in the perfusate flow path and that covers the opening at the bottom of the basin so as to be configured to filter any of the perfusate that flows through the opening by preventing large particles in the perfusate from entering the opening, while ensuring a sufficient flow rate of the perfusate through the opening to maintain the perfusion of the organ or tissue; anda fine filter, less coarse than the coarse filter, downstream of the coarse filter in the perfusate flow path,wherein the coarse filter is located so that, during the perfusion of the organ or tissue, the coarse filter is accessible to a practitioner by way of another opening in the organ container. 12. The apparatus of claim 11, wherein the coarse filter constitutes an exterior portion of the organ container, the exterior portion at least partly forming the basin. 13. The apparatus of claim 12, further comprising a cradle disposed within the basin, the cradle having an organ supporting surface configured to support the organ. 14. The apparatus of claim 11, wherein the fine filter is disposed within a fluid conduit that is downstream of the coarse filter and that is in fluid communication with the coarse filter. 15. The apparatus of claim 14, wherein the coarse filter is larger than the fine filter. 16. The apparatus of claim 11, further comprising: a pump disposed between the coarse filter and the fine filter in the perfusate flow path. 17. The apparatus of claim 11, wherein the coarse filter is sized to (i) block the large particles that would clog the fine filter while (ii) not becoming clogged itself by the large particles. 18. The apparatus of claim 11, further comprising: a pump;a pressure sensor;an oxygenator; anda bubble trap. 19. The apparatus of claim 18, wherein the perfusate flow path comprises a conduit that begins at the coarse filter and then passes, in order, the pump, the pressure sensor, the fine filter, the oxygenator, and the bubble trap before returning to the organ container. 20. The apparatus of claim 11, wherein a width of the coarse filter is between about 4 and 5 inches. 21. The apparatus of claim 14, wherein the coarse filter has an area that is at least two times a cross-sectional area of the fluid conduit. 22. The apparatus of claim 11, wherein the organ container comprises an extended portion that is at a bottom region of the organ container and that forms a secondary chamber between the coarse filter and a fluid conduit. 23. The apparatus of claim 11, wherein the coarse filter is a screen filter. 24. The apparatus of claim 11, wherein the fine filter is a cartridge or capsule filter. 25. The apparatus of claim 11, wherein a filter surface area of the fine filter is about 0.5 ft2. 26. The apparatus of claim 11, wherein the coarse filter has an average mesh opening size of 100 to 10,000 microns. 27. A sterilized disposable kit, configured to be moved relative to an organ perfusion apparatus, and comprising sterilized packaging containing: a sterilized organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate may flow from the organ container to the organ perfusion apparatus during perfusion of the organ or tissue locatable in the basin,a sterilized coarse filter that covers the opening at the bottom of the basin so as to be configured to filter any of the perfusate that flows through the opening by preventing large particles in the perfusate from entering the opening, while ensuring a sufficient flow rate of the perfusate through the opening to maintain the perfusion of the organ or tissue,wherein the coarse filter is located so that, during the perfusion of the organ or tissue, the coarse filter is accessible to a practitioner by way of another opening in the organ container. 28. The kit of claim 27, further comprising a sterilized fine filter disposed inside of the sterilized packaging, the coarse filter being coarser than the fine filter. 29. The kit of claim 28, wherein the coarse filter constitutes an exterior portion of the sterilized organ container, the exterior portion at least partly forming the basin. 30. The kit of claim 29, further comprising a fluid conduit, an oxygenator, and a bubble trap, contained in the sterilized packaging. 31. An apparatus for filtering perfusate, configured to be moved relative to an organ perfusion apparatus, and comprising: an organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate may flow from the organ container to the organ perfusion apparatus during perfusion of the organ or tissue locatable in the basin; anda coarse filter covering the opening at the bottom of the basin so as to be configured to filter any of the perfusate that flows through the opening by preventing large particles in the perfusate from entering the opening, while ensuring a sufficient flow rate of the perfusate through the opening to maintain the perfusion of the organ or tissue,wherein the coarse filter is located so that, during the perfusion of the organ or tissue, the coarse filter is accessible to a practitioner by way of another opening in the organ container, andwherein the coarse filter is disposed inside a wall of the basin that is at least partly formed by an exterior portion of the organ container. 32. An apparatus for filtering perfusate, configured to be moved relative to an organ perfusion apparatus, and comprising: an organ container having a basin configured to receive an organ or tissue and a perfusate bath, a bottom of the basin having formed therein an opening through which perfusate may flow from the organ container to the organ perfusion apparatus during perfusion of the organ or tissue locatable in the basin; anda coarse filter covering the opening at the bottom of the basin so as to be configured to filter any of the perfusate that flows through the opening by preventing large particles in the perfusate from entering the opening, while ensuring a sufficient flow rate of the perfusate through the opening to maintain the perfusion of the organ or tissue, wherein:the coarse filter is located so that, during the perfusion of the organ or tissue, the coarse filter is accessible to a practitioner by way of another opening in the organ container, andthe filtering apparatus is configured so that, in use, (i) the perfusate flows downward through the coarse filter and (ii) the perfusate flows downward from the coarse filter through the opening so as to exit the organ container.
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