Method and apparatus for characterization of clot formation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/02
A61B-008/08
G01N-029/11
G01N-029/34
출원번호
US-0791915
(2013-03-09)
등록번호
US-9723996
(2017-08-08)
발명자
/ 주소
Walker, William F.
Lawrence, Michael B.
Viola, Francesco
Sande, Margaret Kramer
출원인 / 주소
Hemosonics, LLC
대리인 / 주소
Meunier Carlin & Curfman LLC
인용정보
피인용 횟수 :
0인용 특허 :
77
초록▼
Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue.
Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby.
대표청구항▼
1. A method of characterizing at least one hemostatic function of a blood sample, said method comprising: testing a first portion of the blood sample, wherein said testing comprises causing, by a processor, generation of a deformation of the sample by applying a series of acoustic pulses to the firs
1. A method of characterizing at least one hemostatic function of a blood sample, said method comprising: testing a first portion of the blood sample, wherein said testing comprises causing, by a processor, generation of a deformation of the sample by applying a series of acoustic pulses to the first portion, wherein at least one of the pulses is of sufficiently high intensity to induce physical displacement of the first portion;estimating, by the processor, based on one or more received measurements from the testing of the first portion, a first quantitative value of said hemostatic function of the first portion, wherein the first quantitative value describes a viscoelastic property of the first portion;treating a second portion of the blood sample with a treatment to vary said hemostatic function from said first quantitative value of the hemostatic function of the first portion having been estimated;testing the second portion of the blood sample having been treated, wherein said testing comprises causing, by a processor, generation of a deformation of the sample by applying a second series of acoustic pulses to the second portion, wherein at least one of the pulses is of sufficiently high intensity to induce physical displacement of the second portion; andestimating, by the processor, based on one or more received measurements from the testing of the second portion, a second quantitative value of said hemostatic function of the second portion, wherein the second quantitative value describes a viscoelastic property of the second portion;wherein compared results of said first quantitative value with said second quantitative value are used, by a processor, to evaluate viscoelastic parameters associated with an effect of said treating on said hemostatic function of the blood sample, wherein the viscoelastic parameters are derived from the compared results. 2. The method of claim 1, wherein said testing a first portion of the blood sample and said testing the second portion of the blood sample are performed in parallel. 3. The method of claim 1, further comprising: treating a third portion of the blood sample with a treatment to vary said hemostatic function from said first and second quantitative values of the hemostatic function of the first and second portions having been estimated;testing the third portion of the blood sample having been treated, wherein said testing comprises causing, by the processor, generation of a deformation of the sample by applying a third series of acoustic pulses to the third portion, wherein at least one of the pulses is of sufficiently high intensity to induce physical displacement of the third portion;estimating a third quantitative value of said hemostatic function of the third portion, wherein the third quantitative value describes a viscoelastic property of the third portion;comparing said third quantitative value with said first and second quantitative values; andevaluating an effect of said treating on said hemostatic function of the blood sample. 4. The method of claim 1, wherein said treating comprises treating the second portion of the blood with an anti-clotting or pro-clotting treatment. 5. The method of claim 1, wherein said testing further comprises: measuring a displacement, either directly or indirectly, of the blood sample resulting from said induced physical displacement thereof. 6. The method of claim 5, wherein the temperature of the blood sample is controlled over a duration of said measuring a displacement. 7. The method of claim 5, further comprising repeating said generating and estimating steps after passage of a time interval. 8. The method of claim 7, wherein said estimating is based on receiving at least two of said acoustic pulses reflected from the blood sample and estimating the hemostatic function based on the acoustic pulses received. 9. The method of claim 7, wherein said estimating is based on receiving optical reflections from the biological material as the biological material is being physically displaced and estimating the at least one property based on the optical reflections received. 10. The method of claim 7, wherein said generating and estimating steps are repeated after passage of each of a plurality of predetermined time intervals. 11. The method of claim 7, wherein said hemostatic function comprises at least one parameter determined by fitting experimental data including a plurality of said estimates or measurements, to a theoretical model defining the hemostatic function. 12. The method of claim 1, wherein said hemostatic function comprises at least one force-free parameter. 13. The method of claim 7, further comprising receiving at least a portion of said pulses that pass through the blood sample and estimating at least one acoustic property of the blood sample. 14. The method of claim 13, further comprising estimating a magnitude of applied force of the at least one pulse having sufficiently high intensity to induce physical displacement of the blood sample, based upon said at least one estimated acoustic property. 15. The method of claim 13, wherein said at least one acoustic property comprises at least one of attenuation and speed of sound. 16. The method of claim 1, wherein the blood sample includes at least one of a whole blood, a platelet poor plasma or a platelet rich plasma. 17. A method of characterizing at least one hemostatic function of a blood sample, said method comprising: testing, via a processor, a first portion of the blood sample, wherein said testing comprises i) inducing a physical deformation of the first portion of the blood sample by applying a series of acoustic pulses to the first portion, wherein at least one of the pulses is of sufficiently high intensity to induce physical displacement of the first portion and ii) measuring the deformation;estimating, by the processor, based on one or more received measurements from the testing of the first portion, a first quantitative value of said hemostatic function of the first portion, wherein the first quantitative value describes a viscoelastic property of the first portion;treating a second portion of the blood sample with a treatment to vary said hemostatic function from said first quantitative value of the hemostatic function of the first portion having been estimated;testing, via the processor, the second portion of the blood sample having been treated, wherein said testing comprises i) inducing a physical deformation of the second portion of the blood sample by applying a series of acoustic pulses to the first portion, wherein at least one of the pulses is of sufficiently high intensity to induce physical displacement of the first portion and ii) measuring the deformation;estimating, by the processor, based on one or more received measurements from the testing of the second portion, a second quantitative value of said hemostatic function of the second portion, wherein the second quantitative value describes a viscoelastic property of the second portion;wherein compared results of said first quantitative value with said second quantitative value are used, by a processor, to evaluate viscoelastic parameters associated with an effect of said treating on said hemostatic function of the blood sample, wherein the viscoelastic parameters are derived from the compared results. 18. The method of claim 1, wherein the viscoelastic parameters comprise a modulus of elasticity. 19. The method of claim 17, wherein the viscoelastic parameters comprise a modulus of elasticity.
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