System and method for detecting sleep onset in a subject based on responsiveness to breathing cues
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/08
A61B-005/00
A61B-005/087
A61M-016/00
A61B-005/03
A61M-016/16
A61B-005/091
출원번호
US-0697113
(2011-04-25)
등록번호
US-9724038
(2017-08-08)
국제출원번호
PCT/IB2011/051790
(2011-04-25)
§371/§102 date
20121109
(20121109)
국제공개번호
WO2011/141843
(2011-11-17)
발명자
/ 주소
Baloa Welzien, Leonardo Alberto
Laura Lapoint, Manuel
Sibenaller, Sara Marie
출원인 / 주소
Koninklijke Philips N.V.
인용정보
피인용 횟수 :
0인용 특허 :
4
초록▼
A wake-to-sleep transition for a subject is detected based on responsiveness to breathing cues provided to the subject. A pressurized flow of breathable gas to the airway of subject having one or more gas parameters that are adjusted to provide breathing cues to the subject. Based on a detected conf
A wake-to-sleep transition for a subject is detected based on responsiveness to breathing cues provided to the subject. A pressurized flow of breathable gas to the airway of subject having one or more gas parameters that are adjusted to provide breathing cues to the subject. Based on a detected conformance of the respiration of the subject to the breathing cues, a determination is made as to whether the subject is awake or asleep.
대표청구항▼
1. A system configured to provide sleep-triggered pressure-based airway support therapy for a subject via pressure-based breathing cues and breathing-cue based sleep detection, the system comprising: one or more pressure generators configured to generate a pressurized flow of breathable gas for deli
1. A system configured to provide sleep-triggered pressure-based airway support therapy for a subject via pressure-based breathing cues and breathing-cue based sleep detection, the system comprising: one or more pressure generators configured to generate a pressurized flow of breathable gas for delivery to the airway of the subject;one or more sensors for placement at or near an airway of the subject to obtain and measure gas at or near the airway of the subject and configured to generate output sensor signals conveying information related to a gas parameter of the pressurized flow of breathable gas at or near the airway of the subject; andone or more physical computer processors configured by computer readable instructions to:cause, via at least one of the one or more pressure generators, multiple adjustments of the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject;determine conformance of respiration of the subject to the breathing cues provided by the multiple adjustments of the pressurized flow of breathable gas, the conformation determination being based on the output sensor signals and the breathing cues, the conformance determination comprising determining a conformance metric that quantifies a synchronization difference between respiration of the subject and the breathing cues for a predetermined number of breaths, wherein the predetermined number of breaths is greater than one and adjusted based on a noise level in the conformance metric for the predetermined number of breaths;determine a threshold level of conformance for the subject over a period of time;detect that the subject is asleep based on the conformance metric breaching the threshold level of conformance; andresponsive to detecting that the subject is asleep, initiate a pressure support therapy to support the airway of the subject using at least one of the one or more pressure generators to increase pressure at or near the airway of the subject. 2. The system of claim 1, wherein the detection that the subject is asleep is based on analysis of one or more of a breath to breath variability of one or more breathing parameters, an intrabreath variability in the one or more breathing parameters, a drop in the one or more breathing parameters, or a dynamic frequency interbreath variability. 3. The system of claim 1, wherein the one or more physical computer processors are further configured such that the conformance metric quantifies conformance on an individual breath basis for the predetermined number of breaths. 4. The system of claim 3, wherein the one or more physical computer processors are further configured such that the conformance metric comprises an average inspiration extension time or an average expiration extension time over the predetermined number of breaths. 5. The system of claim 1, wherein the one or more physical computer processors cause the multiple adjustments of the pressurized flow of breathable gas by causing, via at least one of the one ore more pressure generators, multiple pressure adjustments or flow rate adjustments to the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject. 6. A method of detecting an awake-to-sleep transition in a subject, the method comprising: generating, with one or more pressure generators, a pressurized flow of breathable gas for delivery to the airway of the subject;obtaining, with one or more sensors placed at or near the airway of the subject, output sensor signals conveying information related to a gas parameter of the pressurized flow of breathable gas;causing, with one or more processors, via a pressure generator, multiple adjustments of the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject;determining, with one or more processors, conformance of respiration of the subject to the breathings cues provided by the multiple adjustments of the pressurized flow of breathable gas, the conformance determination being based on the output sensor signals and the breathing cues, the conformance determination comprising determining a conformance metric that quantifies a synchronization difference between respiration of the subject and the breathing cues for a predetermined number of breaths, wherein the predetermined number of breaths is greater than one and adjusted based on a noise level in the conformance metric for the predetermined number of breaths;determining, with the one or more processors, a threshold level of conformance for the subject over a period of time;detecting, with the one or more processors, that the subject is asleep based on the conformance metric breaching the threshold level of conformance; andresponsive to detecting that the subject is asleep, initiating, with the one or more processors, a pressure support therapy to support the airway of the subject using at least one of the one or more pressure generators to increase pressure at or near the airway of the subject. 7. The method of claim 6, wherein the conformance metric quantifies conformance on an individual breath basis for the predetermined number of breaths. 8. The method of claim 6, wherein causing the multiple adjustments of the pressurized flow of breathable gas comprises causing, via a pressure generator, multiple pressure adjustments or flow rate adjustments to the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject. 9. A system configured to detect an awake-to-sleep transition in a subject, the system comprising: means for obtaining sensor information related to a gas parameter of the pressurized flow of breathable gas;means for causing multiple adjustments of the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject;means for determining conformance of respiration of the subject to the breathing cues provided by the multiple adjustments of the pressurized flow of breathable gas, the conformance determination being based on the output sensor signals and the breathing cues, the conformance determination comprising determining a conformance metric that quantifies a synchronization difference between respiration of the subject and the breathing cues for a predetermined number of breaths, wherein the predetermined number of breaths is greater than one and adjusted based on a noise level in the conformance metric for the predetermined number of breaths;means for determining a threshold level of conformance for the subject over a period of time;means for detecting that the subject is asleep based on the conformance metric breaching the threshold level of conformance; andmeans for, responsive to detecting that the subject is asleep, initiating a pressure support therapy to support the airway of the subject to increase pressure at or near the airway of the subject. 10. The system of claim 9, wherein the conformance metric quantifies conformance on an individual breath basis for the predetermined number of breaths. 11. The system of claim 9, wherein causing the multiple adjustments of the pressurized flow of breathable gas comprises causing multiple pressure adjustments or flow rate adjustments to the pressurized flow of breathable gas over a period of time to provide breathing cues to the subject. 12. The system of claim 1, wherein the breathing cues gradually change from breath to breath. 13. The system of claim 12, wherein the gradually changing breathing cues comprises a gradual change in one or more of a breathing rate, inspiration time, expiration time, exhalation flow rate, peak flow of respiration, or tidal volume from breath to breath. 14. The method of claim 6, wherein the breathing cues gradually change from breath to breath. 15. The method of claim 14, wherein the gradually changing breathing cues comprises a gradual change in one or more of a breathing rate, inspiration time, expiration time, exhalation flow rate, peak flow of respiration, or tidal volume from breath to breath. 16. The system of claim 9, wherein the breathing cues gradually change from breath to breath, and wherein the gradually changing breathing cues comprises a gradual change in one or more of a breathing rate, inspiration time, expiration time, exhalation flow rate, peak flow of respiration, or tidal volume from breath to breath. 17. The system of claim 1, wherein the one or more physical computer processors are further configured to: determine the noise level in the conformance metric; andadjust the predetermined number of breaths to be measured,wherein determining the conformance metric comprises determining the conformance metric based on the adjusted predetermined number of breadths. 18. The system of claim 1, wherein the one or more physical computer processors are further configured to: iteratively perform over a period of time, until at least detection that the subject is asleep, the following:(1) the multiple adjustments of the pressurized flow of breathable gas;(2) the determination of conformance of respiration of the subject to the breathing cues, including the determination of the conformance metric; and(3) the determination of the threshold level of conformance.
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이 특허에 인용된 특허 (4)
Estes Mark C. ; Mechlenburg Douglas M. ; Fiore John H., Method and apparatus for providing positive airway pressure to a patient.
Cho, Yong Kyun; Jensen, Donald N.; Mongeon, Luc R., Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same.
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