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Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/04
  • C12N-015/00
  • C12N-015/63
  • A61K-048/00
  • A61K-031/7088
  • C12N-015/85
  • A01K-067/00
  • A61K-035/12
출원번호 US-0864265 (2015-09-24)
등록번호 US-9724430 (2017-08-08)
발명자 / 주소
  • Merenick, Bethany Lynn
  • Beech, Robert P.
  • Reed, Thomas D.
  • Tretiakova, Anna P.
  • Peterson, Richard E.
출원인 / 주소
  • Intrexon Corporation
대리인 / 주소
    Sterne, Kessler, Goldstein and Fox, P.L.L.C.
인용정보 피인용 횟수 : 0  인용 특허 : 249

초록

The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.

대표청구항 ▼

1. A composition comprising: (1) a first polynucleotide encoding a gene switch, said gene switch comprising at least one transcription factor sequence, wherein said at least one transcription factor sequence encodes a ligand-dependent transcription factor in operable association with a hypoxia-induc

이 특허에 인용된 특허 (249)

  1. Hermeking, Heiko; Vogelstein, Bert; Kinzler, Kenneth W., 14-3-3&sgr; arrests the cell cycle.
    상세보기
  2. Westphal,Christoph H.; Lindberg,Iris; Leder,Philip, 7B2 knockout transgenic animals as models of endocrine disease.
    상세보기
  3. Asina, Shirin; Jain, Kanti; Rubin, Albert L.; Smith, Barry; Stenzel, Kurt, Agarose coated agarose beads containing cancer cells which produce cancer-cell proliferation-suppressing material.
    상세보기
  4. Kennedy, Joseph P.; Isayeva, Irada S., Amphiphilic networks, implantable immunoisolatory devices, and methods of preparation.
    상세보기
  5. Birkenbach, Mark; Kieff, Elliot, Antibodies that bind Epstein Barr virus induced proteins.
    상세보기
  6. Lee,Mu En; Layne,Matthew D.; Yet,Shaw Fang, Aortic carboxypeptidase-like polypeptide.
    상세보기
  7. Anderson,David J.; Garcia Cardena,Guillermo; Gimbrone, Jr.,Michael A.; Wang,Hai U., Artery smooth muscle-and vein smooth muscle-specific proteins and uses therefor.
    상세보기
  8. Reed John C., Bax promoter sequence and screening assays for indentifying agents that regulate bax gene expression.
    상세보기
  9. Gentile Frank T. ; Winn Shelley R. ; Lysaght Michael ; Baurmeister Ulrich,DEX ; Wechs Friedbert,DEX ; Rottger Henning,DEX, Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane.
    상세보기
  10. Hormann,Robert Eugene; Potter,David W.; Chortyk,Orestes; Tice,Colin M.; Carlson,Glenn Richard; Meyer,Andrew; Opie,Thomas R., Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex.
    상세보기
  11. Sun,Zairen; Fan,Wufang; Kovacs,Karl F.; Li,Xuan; Jay,Gilbert, Breast cancer transcription factor gene and uses.
    상세보기
  12. Kaufmann, Joerg, CIF130 inhibits cell cycle progression.
    상세보기
  13. Kaufmann Joerg, CIF150/hTAFII150 is necessary for cell cycle progression.
    상세보기
  14. Kelvin,David; Cameron,Mark J.; Persad,Desmond, CXCL10-based diagnosis and treatment of respiratory illnesses.
    상세보기
  15. Markowitz, Sanford D.; Brattain, Michael G.; Willson, James K. V., Cancer diagnosis and therapy based on mutations in TGF-β receptors.
    상세보기
  16. Felgner Philip L. (Rancho Santa Fe CA) Kumar Raj (San Diego CA) Basava Channa (San Diego CA) Border Richard C. (Poway CA) Hwang-Felgner Jiin-Yu (Rancho Santa Fe CA), Cationic lipids for intracellular delivery of biologically active molecules.
    상세보기
  17. Butler Mark D. ; Drumheller Paul D. ; Mish Stanley L., Cell encapsulation device.
    상세보기
  18. Jung, Neon-Cheol; Kim, Jin-Man; Hong, Seung-Suh; Lee, Hyun-Soo; Seong, Young-Rim; Lee, Jae-Ho, Cell growth inhibiting and cell differentiation specific SYG972 gene, genomic DNA and promoter thereof.
    상세보기
  19. Quertermous Thomas (Cambridge MA) Lee Mu-En (Boston MA), Cell specific gene regulators.
    상세보기
  20. Sedlacek Hans-Harald,DEX ; Wick Marisa,DEX ; Muller Rolf,DEX, Cell-specific gene therapy using as promoter novel promoters for tissue inhibitors of metalloproteinase-3.
    상세보기
  21. Terek,Richard M., Chondrosarcoma associated genes.
    상세보기
  22. Chen Feng-Jing ; Patel Mahesh V., Clear oil-containing pharmaceutical compositions.
    상세보기
  23. Sridaran Natesan ; Michael Z. Gilman, Compositions and method for regulation of transcription.
    상세보기
  24. Fink,John K.; Rainier,Shirley; Nicholls,Robert D.; Chai,Jinghua, Compositions and methods for detecting and treating neurological conditions.
    상세보기
  25. Natesan Sridaran ; Gilman Michael Z., Compositions and methods for regulation of transcription.
    상세보기
  26. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsul.
    상세보기
  27. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsul.
    상세보기
  28. Baetge Edward E. ; Hammang Joseph P. ; Gentile Frank T. ; Lindner Mark D. ; Winn Shelley R. ; Emerich Dwaine F., Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained i.
    상세보기
  29. Baetge Edward E. ; Hammang Joseph P. ; Gentile Frank T. ; Lindner Mark D. ; Winn Shelley R. ; Emerich Dwaine F., Compositions for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules.
    상세보기
  30. Soon-Shiong Patrick ; Desai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release.
    상세보기
  31. Osslund,Timothy D.; Clogston,Christi L.; Crampton,Shon Lee; Bass,Randal B., Crystals of etanercept and methods of making thereof.
    상세보기
  32. Patrick Soon-Shiong ; Neil Desai ; Nilesh Ron ; Andrew Sojomihardjo S. ; Roswitha Heintz ; Francesco Curcio, Cytoprotective biocompatible containment systems for biologically active materials and methods of making same.
    상세보기
  33. Soon-Shiong Patrick ; Desai Neil P. ; Heintz Roswitha E., Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials.
    상세보기
  34. Paul Greengard ; Barbara Porton ; Hung-Teh Kao, DNA encoding the human synapsin III gene and uses thereof.
    상세보기
  35. Kandel, Eric R.; Mayford, Mark, DNA regulatory element for the expression of transgenes in neurons of the mouse forebrain.
    상세보기
  36. Ain Kenneth Bruce ; Venkataraman Gopalakrishnan, DNA sequence corresponding to the minimal essential promoter of the human sodium-iodide symporter (hNIS).
    상세보기
  37. Ip,Nancy Y.; Cheung,William M. W., DNA sequence encoding a retinoic acid regulated protein.
    상세보기
  38. N?grier, Claude; Rodriguez, Marie H?l?ne; Enjolras, Nathalie, DNA-construct for the tissue-specific expression of a blood coagulation factor.
    상세보기
  39. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
    상세보기
  40. Lanza Robert P. ; Ecker Dawn M. ; Ringeling John ; Marsh Joanne P. ; Chick William, Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule.
    상세보기
  41. Robert P. Lanza ; William Chick, Devices for cloaking transplanted cells.
    상세보기
  42. Hormann,Robert Eugene; Tice,Colin M.; Chortyk,Orestes; Smith,Howard; Meteyer,Thomas, Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex.
    상세보기
  43. Androphy,Elliot J.; Doshi,Nishita; Belayew,Alexandra, Diagnosis and treatment of cancer.
    상세보기
  44. Diss,James K. J.; Coombes,Raoul C.; Djamgoz,Mustafa B. A.; Fraser,Scott P., Diagnosis and treatment of cancer: I.
    상세보기
  45. Wands, Jack R.; de la Monte, Suzanne M.; Ince, Nedim; Carlson, Rolf I., Diagnosis and treatment of malignant neoplasms.
    상세보기
  46. Clark,Abbot F.; Fingert,John; McNatt,Loretta; Stone,Edwin M.; Wang,Wan Heng, Diagnostics and therapeutics for glaucoma.
    상세보기
  47. Raziuddin (Frederick MD) Sarkar Fazlul H. (Rochester Hills MI), ERBB2 promoter binding protein in neoplastic disease.
    상세보기
  48. Palli,Subba Reddy; Kapitskaya,Marrianna Zinovjevna; Cress,Dean Ervin, Ecdysone receptor-based inducible gene expression system.
    상세보기
  49. Jorgen Christensen CA; David K. Creber CA; George C. Holywell CA, Electrolysis cells.
    상세보기
  50. Cohen, Itai; Nagel, Sidney; Rilo, Horacio; Mrksich, Milan, Encapsulating particles with coatings that conform to size and shape of the particles.
    상세보기
  51. Enevold Karl C., Encapsulation compositions and methods.
    상세보기
  52. Enevold Karl C., Encapsulation compositions, and methods.
    상세보기
  53. Lim Franklin (Richmond VA), Encapsulation of biological material.
    상세보기
  54. Patterson Winston Campbell ; Lee Mu-En ; Haber Edgar, Endothelial-cell specific promoter.
    상세보기
  55. Lubon Henryk ; Drohan William N. ; Hennighausen Lother, Expression of a heterologous polypeptide in mammary tissue of transgenic non-human mammals using a long whey acidic prot.
    상세보기
  56. Wolff Jon A. (Madison WI) Duke David J. (Salem OR) Felgner Philip L. (Rancho Santa Fe CA), Expression of exogenous polynucleotide sequences cardiac muscle of a mammal.
    상세보기
  57. Florence Guignard ; Philip M. Murphy ; Christophe Combadiere FR; H. Lee Tiffany, Functional promoter for CCR5.
    상세보기
  58. Yeung,Cho Yau; Hsu,Li Chung; Liu,Shu, G+C-rich binding protein.
    상세보기
  59. Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha A. (Los Angeles CA) Sojomihardjo Soebianto (Pasadena CA), Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
    상세보기
  60. Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  61. Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  62. Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  63. Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  64. Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  65. Hubbell, Jeffrey A.; Pathak, Chandrashekhar P.; Sawhney, Amarpreet S.; Desai, Neil P.; Hossainy, Syed F. A., Gels for encapsulation of biological materials.
    상세보기
  66. Zauderer,Maurice; Evans,Elizabeth E.; Borrello,Melinda A., Gene differentially expressed in breast and bladder cancer, and encoded polypeptides.
    상세보기
  67. Jessell,Thomas M.; Tanabe,Yasuto; William,Christopher, Gene encoding MNR2 and uses thereof.
    상세보기
  68. Sakai,Toshiyuki; Kagaya,Shigehide; Sato,Takamichi; Sukenaga,Yoshikazu; Fujii,Hideji, Gene encoding promoter domain of tumor suppressor gene P51 and use thereof.
    상세보기
  69. Ian Jepson GB; Alberto Martinez GB; Andrew James Greenland GB, Gene switch.
    상세보기
  70. Fisher, Paul B.; Magdalena, Leszczyniecka, Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof.
    상세보기
  71. Changeux Jean-Pierre,FRX ; Picciotto Marina,FRX ; Bessis Alain,FRX, Genomic DNA fragments containing regulatory and coding sequences for the .beta.2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated .
    상세보기
  72. Matzuk,Martin Matthew; Elvin,Julia Andrea, Growth differentiation factor-9 regulatory sequences and uses therefor.
    상세보기
  73. Chada, Kiran K.; Ashar, Hena; Tkachenko, Alex; Zhou, Xianjin, HMGI proteins in cancer and obesity.
    상세보기
  74. Schipper,Hyman M., HO-1 suppressor as a diagnostic and prognostic test for dementing diseases.
    상세보기
  75. Kim,Soogyun; Jang,Hyun Jun, Hair follicle growth factor proteins.
    상세보기
  76. Stevens Richard L. (Sudbury MA) Avraham Shalom (Brighton MA), Hematopoietic cell specific transcriptional regulatory elements of serglycin and uses thereof.
    상세보기
  77. Burn Timothy C. (Bedford MA) Satterthwaite Anne B. (Brighton MA) Tenen Daniel G. (Boston MA), Hematopoietic stem cell specific gene expression.
    상세보기
  78. Gilman Michael Z. ; Natesan Sridaran, Heterologous transcription factors.
    상세보기
  79. Zelent,Arthur; Petrie,Kevin; Guidez,Fabien, Histone deacetylase 9.
    상세보기
  80. Ikeda Jun,JPX ; Kaneda Sumiko,JPX ; Yanagi Hideki,JPX ; Matsumoto Masayasu,JPX ; Yura Takashi,JPX, Human and rat hypoxic stress proteins and DNAs encoding therefor.
    상세보기
  81. Salfeld,Jochen G.; Allen,Deborah J.; Hoogenboom,Hendricus R. J. M.; Kaymakcalan,Zehra; Labkovsky,Boris; Mankovich,John A.; McGuinness,Brian T.; Roberts,Andrew J.; Sakorafas,Paul; Schoenhaut,David; Va, Human antibodies that bind human TNFα.
    상세보기
  82. Reinhard,Christoph, Human cyclin-dependent kinase ().
    상세보기
  83. Polakowska Renata Regina (Pittsford NY) Goldsmith Lowell Alan (Pittsford NY), Human epidermal gene promoter.
    상세보기
  84. Mountz John D. ; Liu Changdan ; Cheng Jianhua ; Koopman William J. ; Zhou Tong, Human fas gene promoter region.
    상세보기
  85. Vihko Pirkko,FIX, Human glandular kallikrein-1 (hK2).
    상세보기
  86. Hanson, Douglas Charles; Neveu, Mark Joseph; Mueller, Eileen Elliott; Hanke, Jeffrey Herbert; Gilman, Steven Christopher; Davis, C. Geoffrey; Corvalan, Jose Ramon, Human monoclonal antibodies to CTLA-4.
    상세보기
  87. Borden Paula Ann ; Heller Renu Anand, Human stromelysin-1 promoter.
    상세보기
  88. Iacovitti,Lorraine; Kessler,Mark Alexander, Human tyrosine hydroxylase promoter and uses thereof.
    상세보기
  89. Queen Cary L. (Los Altos CA) Selick Harold E. (Belmont CA), Humanized immunoglobulins.
    상세보기
  90. Owens, Gary K.; Madsen, Cort, Identification of a smooth muscle cell (SMC) specific smooth muscle heavy chain (SM-MHC) promoter/enhancer.
    상세보기
  91. Boman,Bruce M., Immunoassays to detect diseases or disease susceptibility traits.
    상세보기
  92. Berlin, Vivian; Chiu, Maria Isabel; Cottarel, Guillaume; Damagnez, Veronique, Immunosuppressant target proteins.
    상세보기
  93. Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght M, Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products.
    상세보기
  94. Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght M, Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products.
    상세보기
  95. Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasooncellos Alfred V. ; Lysaght M, Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products.
    상세보기
  96. Dionne, Keith E.; Emerich, Dwaine F.; Hoffman, Diane; Sanberg, Paul R.; Christenson, Lisa; Hegre, Orion D.; Scharp, David W.; Lacy, Paul E.; Aebischer, Patrick; Vasconcellos, Alfred V.; Lysaght, Mich, Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products.
    상세보기
  97. Hideaki Tahara JP; Michael T. Lotze ; Yasuhiko Nishioka JP, In situ injection of antigen-presenting cells with genetically enhanced cytokine expression.
    상세보기
  98. Sawhney, Amarpreet S., In situ polymerizable hydrogels.
    상세보기
  99. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
    상세보기
  100. Jarvis ; Jr. Allan P. (Newburyport MA) Koch George A. (Medfield MA) Abrams Paul G. (Washington DC), Induction of immune response by immunization with encapsulated antigen-producing cells.
    상세보기
  101. Massaad, Charbel; Berenbaum, Francis; Olivier, Jean-Luc; Salvat, Colette; Bereziat, Gilbert, Inflammation inducible hybrid promoters, vectors comprising them and uses thereof.
    상세보기
  102. Munford Robert S., Inflammation-induced expression of a recombinant gene.
    상세보기
  103. Munford Robert S., Inflammation-induced expression of a recombinant gene.
    상세보기
  104. Hockfield, Susan; Matthews, Russell T., Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors.
    상세보기
  105. Karaplis,Andrew C.; Goltzman,David; Lipman,Mark L.; Henderson,Janet E., Inhibition of PEX in the treatment of metabolic bone diseases.
    상세보기
  106. Terri Lynn Davis-Smyth ; Helen Hsifei Chen ; Leonard Presta ; Napoleone Ferrara, Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production.
    상세보기
  107. Dionne Keith E. ; Hegre Orion D. ; Flanagan Thomas R. ; Hazlett Tyrone F. ; Doherty Edward J., Inner supported biocompatible cell capsules.
    상세보기
  108. Dionne Keith E. ; Hegre Orion D. ; Flanagan Thomas R. ; Hazlett Tyrone F. ; Doherty Edward J., Inner-supported, biocompatible cell capsules.
    상세보기
  109. Hsu Adam Chi-Tung ; Aller Harold Ernest ; Le Dat Phat ; Hamp Donald Wesley ; Weinstein Barry ; Murphy Raymond August, Insecticidal N'-substituted-N,N'-disubstitutedhydrazines.
    상세보기
  110. Hsu Adam C. (Lansdale PA) Aller Harold E. (Norristown PA), Insecticidal N′-substituted-N,N′-diacylhydrazines.
    상세보기
  111. Lidert Zev (Doylestown PA) Le Dat P. (North Wales PA) Hormann Robert E. (Philadelphia PA) Opie Thomas R. (North Wales PA), Insecticidal N′-substituted-N,N′-diacylhydrazines.
    상세보기
  112. Murphy Raymond A. (Lansdale PA) Hsu Adam C. (Lansdale PA), Insecticidal N′-substituted-N′-substituted N,N′-diacylhydrazines.
    상세보기
  113. Hsu Adam C. (Lansdale PA) Aller Harold E. (Norristown PA) Murphy Raymond A. (Lansdale PA) Le Dat P. (North Wales PA) Hamp Donald W. (Horsham PA) Weinstein Barry (Dresher PA), Insecticidal N′substituted-N-N′-disubstituted-hydrazines.
    상세보기
  114. Tice,Colin M.; Michelotti,Enrique L.; Hormann,Robert E., Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex.
    상세보기
  115. Lethe, Bernard; Lucas, Sophie; De Smet, Charles; Godelaine, Daniele; Boon-Falleur, Thierry, Lage-1 tumor associated nucleic acids.
    상세보기
  116. Carlson Glenn Richard ; Cress Dean Ervin ; Dhadialla Tarlochan Singh ; Hormann Robert Eugene ; Le Dat Phat, Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex.
    상세보기
  117. Farnham,Peggy J.; Graveel,Carrie R., Liver tumor marker sequences.
    상세보기
  118. Farnham,Peggy J.; Graveel,Carrie R.; Harkins Perry,Sarah R., Liver tumor marker sequences.
    상세보기
  119. Mooney David J. ; Langer Robert S. ; Vacanti Joseph P., Localized delivery of factors enhancing survival of transplanted cells.
    상세보기
  120. Kim, Myong-Jae, Low-power nonvolatile semiconductor memory device.
    상세보기
  121. Soon-Shiong Patrick ; Desai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
    상세보기
  122. Anderson Garth R. (Elma NY) Estes Scott D. (Somerville MA) Stoler Daniel L. (Getzville NY), Mammalian anoxia-responsive regulatory element.
    상세보기
  123. Gould Michael N. ; Chen Kai-Shun, Mammary gland-specific promoters.
    상세보기
  124. Miyata, Toshio, Megsin promoter.
    상세보기
  125. Fisher, Paul B.; Madireddi, Malavi T., Melanoma differentiation associated gene-7 promoter and uses thereof.
    상세보기
  126. Gentile Frank ; Shoichet Molly ; Harris Milton, Membrane formed by an acrylonitrile-based polymer.
    상세보기
  127. Li,Yuanhao; Yu,De Chao, Metastatic colon cancer specific promoter and uses thereof.
    상세보기
  128. Mills John F. ; Doherty Edward J. ; Hazlett Tyrone F. ; Dionne Keith E. ; Warner Nicholas F. ; Cain Brian M. ; Rein David H., Method and apparatus for sealing implantable membrane encapsulation devices.
    상세보기
  129. Demetriou Achilles A. ; Ljubimova Julia Y., Method and probe for detection of gene associated with liver neoplastic disease.
    상세보기
  130. Holland Laura M. (Providence RI) Hammang Joseph P. (Barrington RI) Rudnick Seth A. (Barrington RI) Lysaght Michael J. (E. Greenwich RI) Dionne Keith E. (Rehoboth MA), Method for implanting encapsulated cells in a host.
    상세보기
  131. Soon-Shiong Patrick ; Desai Neil P. ; Heintz Roswitha E., Method for making cytoprotective, biocompatible, retrievable microcapsule containment systems.
    상세보기
  132. Evans, Ronald M.; No, David; Saez, Enrique, Method for modulating expression of exogenous genes in mammalian systems, and products related thereto.
    상세보기
  133. Ung-Chhun Neng S. ; Johnson Richard J. ; Laurin Dean ; Cunahan Crystal M., Method for producing improved medical devices and devices so produced.
    상세보기
  134. Minoru Hirose JP; Junko Hashimoto JP; Tadashi Yoshimura JP, Method for the detection of telomerase activity.
    상세보기
  135. Goff Stephen A. ; Crossland Lyle D. ; Privalle Laura S., Method of controlling the fertility of a plant.
    상세보기
  136. Opara Emmanuel C., Method of culturing, cryopreserving and encapsulating pancreatic islet cells.
    상세보기
  137. Waterman,Marian L.; Holcombe,Randall F.; Marsh,J. Lawrence; Hovanes,Karine; Li,Tony Wai Hung, Method of detection and treatment of colon cancer.
    상세보기
  138. Gonzalez-Zulueta, Mirella; Shamloo, Mehrdad; McFarland, K.C.; Chin, Daniel; Wieloch, Tadeusz; Melcher, Thorsten, Method of diagnosing ischemic stroke via UCP-2 detection.
    상세보기
  139. Rottman Fritz (Pepper Pike OH) Helms Sherron (University Hghts. OH), Method of directing transgenic expression in animals using a prolactin promoter.
    상세보기
  140. Hollingshead Melinda G. (Knoxville MD), Method of evaluating chemotherapeutic agents in vivo.
    상세보기
  141. Chai, Karl X.; Chen, Li-Mei; Chao, Lee; Chao, Julie, Method of identifying and treating invasive carcinomas.
    상세보기
  142. Hochberg Abraham,ILX ; Ayesh Suhail,ILX, Methods and compositions for inducing tumor-specific cytotoxicity.
    상세보기
  143. Vournakis, John N.; Finkielsztein, Sergio; Pariser, Ernest R.; Helton, Mike, Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system.
    상세보기
  144. Farr Spencer B. ; Todd Marque D., Methods and kits for eukaryotic gene profiling.
    상세보기
  145. Johnson,Jeffrey D.; Blume,John E.; Palma,John F.; Zhou,Yun Ping, Methods and reagents for diagnosis and treatment of diabetes.
    상세보기
  146. Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght M, Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core.
    상세보기
  147. Baban, Soheyl; Bernard, Monique; Cherry, Elana; Gosselin, Diane; Hugo, Patrice; Malette, Brigitte; Miron, Pierre; Privé, Charles; Shazand, Kamran, Methods for determining the likelihood of endometriosis in a female subject.
    상세보기
  148. Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Sharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght Mi, Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core.
    상세보기
  149. Evans,Ronald M.; Saez,Enrique, Methods for modulating expression of exogenous genes in mammalian systems.
    상세보기
  150. Tanzi Rudolph E. (Canton MA) Kovacs Dora M. (Cambridge MA), Methods for modulating transcription from the amyloid b 상세보기
  • Emmanuel C. Opara, Methods of culturing and encapsulating pancreatic islet cells.
    상세보기
  • Sandell, Linda J.; Xie, Wei-Fen, Methods of targeted expression by the CD-RAP gene promoter.
    상세보기
  • Le,Junming; Vilcek,Jan; Daddona,Peter; Ghrayeb,John; Knight,David; Siegel,Scott, Methods of treating rheumatoid arthritis with anti-TNF antibodies.
    상세보기
  • Lanza Robert P. ; Kuhtreiber Willem M. ; Chick William L., Methods of use of uncoated gel particles.
    상세보기
  • Lanza Robert P. ; Kuhtreiber Willem M. ; Chick William L., Microcapsules and composite microreactors for immunoisolation of cells.
    상세보기
  • Opara, Emmanuel C., Microencapsulated pancreatic islet cells.
    상세보기
  • Goosen Mattheus F. A. (Toronto CAX) O\Shea Geraldine M. (Toronto CAX) Sun Anthony M. (Willowdale CAX), Microencapsulation of living tissue and cells.
    상세보기
  • Goosen Mattheus F. A. (Toronto CAX) O\Shea Geraldine M. (Toronto CAX) Sun Anthony M. F. (Willowdale CAX), Microencapsulation of living tissue and cells.
    상세보기
  • Goosen Mattheus F. A. (Toronto CAX) O\Shea Geraldine M. (Toronto CAX) Sun Anthony M. F. (Willowdale CAX), Microencapsulation of living tissue and cells.
    상세보기
  • Hudziak Robert M. (Corvallis OR) Shepard H. Michael (Rancho Santa Fe CA) Ullrich Axel (Portola Valley CA) Fendly Brian M. (Half Moon Bay CA), Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  • Schlessinger Joseph ; Givol David,ILX ; Bellot Francoise,FRX ; Kris Richard ; Ricca George A. ; Cheadle Christopher ; South Victoria J., Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same.
    상세보기
  • Yu, Hanry; Leong, Kam W.; Chia, Ser-Mien; Wan, Andrew C. A., Multi-layer cell encapsulation for tissue engineering.
    상세보기
  • Ciolino et al., Multicistronic expression units and their use.
    상세보기
  • Schwartz Robert J. (Houston TX) Chow King L. (Houston TX), Mutated skeletal actin promoter.
    상세보기
  • Noti, John D., Myeloid cell promoter and constructs containing same.
    상세보기
  • Tapscott Stephen J. (Seattle WA) Weintraub Harold M. (Seattle WA) Palmer Theodore D. (Kirkland WA), Myod regulatory region.
    상세보기
  • Wu-Wong Jinshyun R. ; Wang Jiahong, Myostatin gene promoter and inhibition of activation thereof.
    상세보기
  • Band,Vimla, NES-1 polypeptides, DNA, and related molecules and methods.
    상세보기
  • Kilgannon Patrick D. ; Gallatin W. Michael, Neuron-specific ICAM-4 promoter.
    상세보기
  • Farb David H. ; Russek Shelley J., Neuron-specific transcriptional promoter.
    상세보기
  • Yanagi Mikio (Okegawa JPX) Sugizaki Hiroyasu (Tokyo JPX) Toya Tetsuya (Yono JPX) Kato Yasuhito (Yono JPX) Shirakura Hidetoshi (Yono JPX) Watanabe Tetsuo (Yono JPX) Yajima Yoshimi (Namegawa JPX) Kodam, New hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient.
    상세보기
  • Schneider,Armin; Klaussner,Bettina; Fischer,Achim; Newrzella,Dieter; G��tz,Bernhard; Rossner,Moritz; Eisenhardt,Gisela; Kuner,Rohini; Trutzel,Annette; Kammandel,Birgitta; Naim,Stephanie Jomana; Schwaninger,Markus, Nucleic acid molecule encoding a neuronal serine-threonine protein kinase.
    상세보기
  • Bussemakers, Marion J.; Verhaegh, Gerald; Schalken, Jack A., Nucleic acid molecules comprising the promoter for PCA3, and uses thereof.
    상세보기
  • Bussemakers,Marion J.; Verhaegh,Gerald; Schalken,Jack A., Nucleic acid molecules comprising the promoter for PCA3, and uses thereof.
    상세보기
  • Pang Shen ; Belldegrun Arie S., Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof.
    상세보기
  • Fisher, Paul B.; Su, Zao-Zhong, Nucleic acids comprising regions of the rat PEG-3 promoter that display elevated expression in human cancer cells and uses thereof.
    상세보기
  • Gordon, Lynn K.; Goodglick, Lee; Goldman, Melissa, Nucleic acids for the diagnosis and treatment of giant cell arteritis.
    상세보기
  • Nguyen,Thai D.; Polansky,Jon R.; Chen,Pu; Chen,Hua, Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders.
    상세보기
  • Chung Leland W. K. ; Kao Chinghai ; Sikes Robert A. ; Ko Song-Chu ; Cheon Jun,KRX, Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues.
    상세보기
  • Hormann,Robert Eugene; Chortyk,Orestes; Le,Dat Phat, Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex.
    상세보기
  • Pahl, Heike, PRV-1 gene and the use thereof.
    상세보기
  • Kennedy, Guilia C., Pancreatic cancer genes.
    상세보기
  • Johnson,Jeffrey D.; Palma,John F.; Schweitzer,Anthony C.; Blume,John E., Pancreatic islet transcription factor and uses thereof.
    상세보기
  • Newman Peter J. (Bayside WI) Gumina Richard J. (Milwaukee WI) Kirshbaum Nancy (Milwaukee WI), Platelet endothelial cell adhesion molecule-1 promoters and uses thereof.
    상세보기
  • Toyoda Hiroo ; Formby Bent, Polynucleic acid sequences that are functionally associated with the development of autoimmune disease.
    상세보기
  • Gurney, Austin L.; Kirchhofer, Daniel K.; Wood, William I., Polypeptides that inhibit human serum-induced cleavage of hepatocyte growth factor.
    상세보기
  • Jain, Kanti; Rubin, Albert L.; Smith, Barry, Preparation of agarose coated, solid agarose-collagen beads containing secretory cells.
    상세보기
  • Jain,Kanti; Rubin,Albert L.; Smith,Barry, Preparation of agarose coated, solid agarose-collagen beads containing secretory cells.
    상세보기
  • Lim Franklin (Richmond VA), Preparation of substances with encapsulated cells.
    상세보기
  • Vitek Michael P. ; Mitsuda Noriaki ; Roses Allen D., Presenilin-1 gene promoter.
    상세보기
  • Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
    상세보기
  • Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha E. (Los Angeles CA), Process for encapsulating biologics using crosslinkable biocompatible encapsulation system.
    상세보기
  • Batich Chris (Gainesville FL) Vaghefi Farid (Foster City CA), Process for microencapsulating cells.
    상세보기
  • Schlom Jeffrey ; Kashmiri Syed V. S. ; Shu Liming, Production of a single-gene-encoded immunoglobulin.
    상세보기
  • Panula Pertti Aarre Juhani,FIX ; Brandt Annika,FIX ; Westerlund Johanna,FIX, Promoter for neuropeptide FF and use thereof for therapy and diagnostics.
    상세보기
  • Alitalo Kari,FIX ; Korhonen Jaana,FIX, Promoter for the receptor tyrosine kinase, Tie.
    상세보기
  • Salbaum Johannes Michael Hermann,DEX ; Masters Colin Louis,AUX ; Beyreuter Konrad Traugott,DEX, Promoter of the gene for the human precursor of the alzheimer's disease and its use.
    상세보기
  • Graulich Wolff,DEX ; Nettelbeck Dirk,DEX ; Sedlacek Hans-Harald,DEX ; Mueller Rolf,DEX, Promoter of the human endoglin gene.
    상세보기
  • Salbaum Johannes M. H. (Waldkirchen DEX) Masters Colin L. (Darlington AUX) Beyreuter Konrad T. (Heidelberg DEX), Promoter region for DNA sequences which encode the precursor of the human A4 amyloid protein.
    상세보기
  • Keith,William Nicol, Promoter regions of the mouse and human telomerase RNA component genes.
    상세보기
  • Abrahams챕n,Lars; Ekblom,Jonas; Forsgren,Margareta; H철rling,Jan; Johansson,Per, Promoter sequences.
    상세보기
  • Kalin,Ned H.; Roseboom,Patrick H.; Landry,Charles F.; Nanda,Steven A., Promoter sequences for corticotropin releasing-factor receptor CRFand method of identifying agents that alter the activity of the promoter sequences.
    상세보기
  • Kalin,Ned H.; Roseboom,Patrick Henry; Nanda,Steven Anil, Promoter sequences for urocortin II and the use thereof.
    상세보기
  • Harats,Dror, Promoters exhibiting endothelial cell specificity and methods of using same.
    상세보기
  • Israeli,Ron S.; Heston,Warren D. W.; Fair,William R., Prostate-specific membrane antigen and uses thereof.
    상세보기
  • Choi,Yongwon; Wong,Brian, Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof.
    상세보기
  • Iwamoto,Keiji; Katayama,Nozomi; Kawamura,Mihoko, Proteins having glucose transporter activity.
    상세보기
  • Graziani,Edmund Idris; Pong,Kevin; Skotnicki,Jerauld, Rapamycin analogues and uses thereof in the treatment of neurological disorders.
    상세보기
  • Graziani,Edmund Idris; Pong,Kevin; Skotnicki,Jerauld, Rapamycin derivatives and the uses thereof in the treatment of neurological disorders.
    상세보기
  • Suh, Dongsang, Recombinant vector for use in gene therapy for insulin-dependent diabetes mellitus and therapeutic composition thereof.
    상세보기
  • Clackson Timothy P. ; Gilman Michael Z. ; Holt Dennis A. ; Keenan Terence P. ; Rozamus Leonard ; Yang Wu, Regulation of biological events using novel compounds.
    상세보기
  • Clackson, Timothy P.; Gilman, Michael Z.; Holt, Dennis A.; Keenan, Terence P.; Rozamus, Leonard; Yang, Wu, Regulation of biological events using novel compounds.
    상세보기
  • Evans Ronald M. (La Jolla CA) Ong Estelita (San Diego CA) Segui Prudimar S. (San Diego CA) Thompson Catherine C. (La Jolla CA) Umesono Kazuhiko (San Diego CA) Giguere Vincent (Etobicoke CAX), Retinoic acid receptor method.
    상세보기
  • Acton Susan Laurene, SR-BI regulatory sequences and therapeutic methods of use.
    상세보기
  • Tatake, Revati J.; Marlin, Steven D.; Barton, Randall W., Self-regulated apoptosis of inflammatory cells by gene therapy.
    상세보기
  • Benoit,Patrick; Schwartz,Bertrand; Branellec,Didier; Chien,Kenneth R.; Chen,Ju, Sequences upstream of the CARP gene, vectors containing them and uses thereof.
    상세보기
  • Olson Eric N. ; Li Li ; Miano Joseph M., Smooth muscle 22.alpha. promoter, gene transfer vectors containing the same, and method of use of the same to target ge.
    상세보기
  • Lee,Amy S., Stress-responsive induction of a therapeutic agent and methods of use.
    상세보기
  • Bolognesi Dani P. (Durham NC) Chen Chin-Ho (Chapel Hill NC) Greenberg Michael L. (Durham NC) Weinhold Kent (Durham NC), Suppressor of HIV replication and transcription.
    상세보기
  • Miller Freda Diane (Montreal CAX) Gloster Andrew (Montreal CAX) Causing Carrie Grace (Montreal CAX) Toma Jean George (Edmonton CAX), Taa 상세보기
  • Young, Lawrence S.; Lipinski, Kai S.; Wrighton, Christopher J., TCF responsive element.
    상세보기
  • Mano Hiroyuki,JPX ; Sakata Tsuneaki,JPX ; Hasegawa Mamoru,JPX, TEC promoter.
    상세보기
  • Tapsak,Mark A.; Rhodes,Rathbun K.; Shults,Mark C.; McClure,Jason D., Techniques to improve polyurethane membranes for implantable glucose sensors.
    상세보기
  • Morin, Gregg B.; Lichtsteiner, Serge P.; Vasserot, Alain P.; Adams, Robert R.; Andrews, William H., Telomerase promoter driving expression of therapeutic gene sequences.
    상세보기
  • Lin,Ming Fong, Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer.
    상세보기
  • Anderson Darrell R. ; Hanna Nabil ; Leonard John E. ; Newman Roland A. ; Reff Mitchell E. ; Rastetter William H., Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen.
    상세보기
  • Bruce R. Zetter ; Lere Bao, Thymosin .beta.-15 promoter and uses thereof.
    상세보기
  • Gossen Manfred (Ringstrasse 33 D-69115 Heidelberg DEX) Bujard Hermann (Remlerstrasse 9 D-69120 Heidelberg DEX), Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters.
    상세보기
  • Berg,Patricia E., Transcription factor, BP1.
    상세보기
  • Natesan Sridaran, Transcriptional activators, and compositions and uses related thereto.
    상세보기
  • de la Brousse Fabienne Charles (San Francisco CA) Chen Jin-long (Millbrae CA), Transcriptional promoter of the murine obesity gene.
    상세보기
  • Auernhammer, Christoph J.; Melmed, Shlomo, Transgenic expression from a SOCS-3 promoter in vertebrate cells.
    상세보기
  • Brunicardi, F. Charles, Treatment of pancreatic adenocarcinoma by cytotoxic gene therapy.
    상세보기
  • Ordahl Charles P. (San Francisco CA) Mar Janet H. (San Francisco CA) Antin Parker B. (San Francisco CA) Cooper Thomas A. (San Francisco CA), Troponin T gene promoter and derivatives thereof.
    상세보기
  • Hanausek-Walaszek Margaret ; Slaga Thomas J. ; Walaszek Zbigniew, Tumor marker protein for cancer risk assessment.
    상세보기
  • Tagawa,Masatoshi, Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells.
    상세보기
  • Killary, Ann; Lott, Steve; Chandler, Dawn, Tumor suppressor CAR-1.
    상세보기
  • Steck,Peter; Pershouse,Mark A.; Jasser,Samar A.; Yung,Alfred W. K.; Tavtigian,Sean V., Tumor suppressor designated TS10q23.3.
    상세보기
  • Harris,Curtis C.; Pedeux,Remy; Nagashima,Makoto; Shiseki,Masayuki, Tumor suppressor gene, p28ING5.
    상세보기
  • Hamada,Katsuyuki, Tumor-specific promotor and use thereof.
    상세보기
  • K?pper, Jan-Heiner; Meyer, Ralph; Meyer-Ficca, Mirella; Kandolf, Reinhard, Tumour-specific vector for gene therapy.
    상세보기
  • Weichselbaum,Ralph R.; Kufe,Donald W., Use of DF3/MUC1 regulated expression in gene therapy.
    상세보기
  • Clark,Abbot F.; Wang,Wan Heng; McNatt,Loretta, Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents.
    상세보기
  • Tinsley Jonathon Mark,GBX ; Davies Kay Elizabeth,GBX ; Dennis Carina, Utrophin gene promotor.
    상세보기
  • Dass,Brinda; MacDonald,Clinton C.; Wallace Shannon,Allison Michelle, Variant cleavage stimulation factor and its encoding nucleic acid.
    상세보기
  • Rajadhyaksha Vithal Jagannath (Mission Viejo CA), Vehicle composition containing 1-substituted azacycloheptan-2-ones.
    상세보기
  • Rajadhyaksha Vithal J. (Mission Viejo CA), Vehicle composition containing 1-substituted azacyclopentan-2-ones.
    상세보기
  • Han,Jia Wen; Chittenden,Thomas, bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter.
    상세보기
  • Wallach David,ILX ; Kuhnert Peter,CHX ; Ehrhardt Gotz,DEX ; Kemper Oliver,DEX, p75 TNF receptor promoters.
    상세보기

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