The current invention is directed to a medical implant made of bulk-solidifying amorphous alloys and methods of making such medical implants, wherein the medical implants are biologically, mechanically, and morphologically compatible with the surrounding implanted region of the body.
대표청구항▼
1. A medical implant object for placement into a region comprising: a body comprising a bulk-solidifying amorphous alloy that retains an amorphous state throughout a section thickness of at least 0.5 mm when cooled from a melt at a critical cooling rate of no more than about 500° C./s and having an
1. A medical implant object for placement into a region comprising: a body comprising a bulk-solidifying amorphous alloy that retains an amorphous state throughout a section thickness of at least 0.5 mm when cooled from a melt at a critical cooling rate of no more than about 500° C./s and having an elastic strain limit of around 1.2% or more, said bulk-solidifying amorphous alloy having a composition that is free from Ni;wherein the body has a plurality of micro-structured surface features on an outer surface thereof, wherein the micro-structured surface features have an average roughness of between 1 to 50 μm and a surface morphology such that the outer surface of the body has mechanical and morphological compatibility with the region. 2. The object of claim 1 wherein the outer surface is coated with a biocompatible material. 3. The object of claim 2 wherein the biocompatible material includes polymethyl methacrylate resin cement reinforced with one or more oxides selected from among alumina, magnesia, zirconia or a combination thereof, and further including a metal primer. 4. A medical implant object for placement into a region comprising: a body comprising a bulk-solidifying amorphous alloy that retains an amorphous state throughout a section thickness of at least 0.5 mm when cooled from a melt at a critical cooling rate of no more than about 500° C./S and having an elastic strain limit of around 1.2% or more;wherein the body has a plurality of micro-structured surface features on an outer surface thereof, wherein the micro-structured surface features have an average roughness of between 1 to 50 μm and a surface morphology such that the outer surface of the body has mechanical and morphological compatibility with the region. 5. The object of claim 4, wherein the micro-structural features on the outer surface of the body comprise a plurality of pores with diameters between about 10 to 500 μm. 6. The object of claim 4, wherein the micro-structural features on the outer surface of the body comprise a surface texture selected from the group consisting of concave, convex, and mixture of concave and convex. 7. The object of claim 4, wherein the bulk-solidifying amorphous alloy is described by the following molecular formula: (Zr,Ti)a(Ni,Cu,Fe)b(Be,Al,Si,B)c, wherein “a” is in the range of from about 30 to 75, “b” is in the range of from about 5 to 60, and “c” in the range of from about 0 to 50 in atomic percentages, wherein the alloy is free from at least one material selected from the group consisting of Ni, Be and Al. 8. The object of claim 4, wherein the bulk-solidifying amorphous alloy is described substantially by the following molecular formula: (Zr)a(Nb,Ti)b(Cu)c(Al)d, where “a” is in the range of from 45 to 65, “b” is in the range of from 0 to 10, “c” is in the range of from 20 to 40, and “d” in the range of from 7.5 to 15 in atomic percentages. 9. The object of claim 4, wherein the bulk-solidifying amorphous alloy has an elastic strain limit of around 1.8% or more. 10. The object of claim 4, wherein the bulk-solidifying amorphous alloy has a high fracture toughness of at least about 10 ksi-in. 11. The object of claim 4, wherein the bulk-solidifying amorphous alloy has a high hardness value of at least about 5.0 GPa. 12. The object of claim 4, wherein the bulk-solidifying amorphous alloy is based on ferrous metals. 13. The object of claim 4, wherein the bulk-solidifying amorphous alloy comprises Zr and Ti, and further comprises a ductile metallic crystalline phase precipitate. 14. The object of claim 4, wherein the bulk-solidifying amorphous alloy is Ni Al, or Be free. 15. The object of claim 4, wherein the body is in the form of a load bearing member. 16. The object of claim 4, wherein the body is in the form of an articulating joint. 17. The object of claim 4, wherein the bulk-solidifying amorphous alloy has a supercooled liquid region of more than 90° C. 18. The object of claim 4, wherein the bulk-solidifying amorphous alloy comprises Be. 19. The object of claim 4 wherein the outer surface is coated with a biocompatible material. 20. The object of claim 19 wherein the biocompatible material includes polymethyl methacrylate resin cement reinforced with one or more oxides selected from among alumina, magnesia, zirconia or a combination thereof, and further including a metal primer.
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