A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.
대표청구항▼
1. A method of preparing a laminate coronary stent comprising: a. providing a stent framework having a plurality of struts, each strut having a luminal, abluminal and side wall surfaces;b. depositing a plurality of bioabsorbable polymer layers on the luminal, abluminal and side wall surfaces of each
1. A method of preparing a laminate coronary stent comprising: a. providing a stent framework having a plurality of struts, each strut having a luminal, abluminal and side wall surfaces;b. depositing a plurality of bioabsorbable polymer layers on the luminal, abluminal and side wall surfaces of each strut of said stent framework to form said laminate coronary stent;c. depositing at least one active agent in crystalline form; andd. sintering the stent after each polymer layer is deposited;wherein said plurality of layers forms a coating on the stent framework, the coating consisting essentially of the bioabsorbable polymer and the active agent in crystalline form, and wherein at least one internal layer comprises the active agent; andwherein the stent framework has a thickness of about 50% or less of a thickness of the laminate coronary stent. 2. The method of claim 1, wherein the stent framework is prepared by a method comprising laser cutting a tube; lithographic transfer to a sheet and/or etching a previously prepared metal stent. 3. The method of claim 1, wherein the stent framework is prepared by a method comprising lithographic transfer to a bioabsorbable sheet. 4. The method of claim 1, wherein the stent framework is prepared by a method comprising etching a previously prepared metal stent made of absorbable material comprising magnesium. 5. The method of claim 1, wherein the stent framework is made of a bioabsorbable polymer or a conductive polymer. 6. The method of claim 1, wherein the stent framework is made of biocompatible non-bioabsorbable material. 7. The method of claim 1, wherein the stent framework is made of stainless steel. 8. The method of claim 1, wherein the stent framework has a thickness of about 1% or less of a thickness of the laminate coronary stent. 9. The method of claim 1, wherein said bioabsorbable polymer is selected from PGA poly(glycolide), LPLA poly(l-lactide), DLPLA poly(dl-lactide), PCL poly(ecaprolactone) PDQ, poly(dioxolane) PGA-TMC, 85115 DLPLG p(dl-lactide-co-glycolide), 75/25DLPLG, 65/35 DLPLG, 50/50 DLPLG, TMC poly(trimethylcarbonate), p(CPP:SA) poly(1,3-bis-p(carboxyphenoxy)propane-co-sebacic acid). 10. The method of claim 1 comprising depositing 4, 10, 20, 50, 100 or more layers. 11. The method of claim 1, wherein the active agent comprises a macrolide immunosuppressive (limus) drug. 12. The method of claim 11, wherein the macrolide immunosuppressive drug comprises one or more of rapamycin, 40-O-(2-Hydroxyethyl)rapamycin (everolimus), 40-O-Benzyl-rapamycin, 40-O-(4′-Hydroxymethyl)benzyl-rapamycin, 40-O-[4′-(1,2-Dihydroxyethyl)]benzyl-rapamycin, 40-O-Allyl-rapamycin, 40-O-[3′-(2,2-Dimethyl-1,3-dioxolan-4(S)-yl)-prop-2′-en-1′-yl]-rapamycin, (2′:E,4′S)-40-O-(4′,5′-Dihydroxypent-2′-en-1′-yl)-rapamycin, 40-O-(2-Hydroxy)ethoxycar-bonylmethyl-rapamycin, 40-O-(3-Hydroxy)propyl-rapamycin, 40-O-(6-Hydroxy)hexyl-rapamycin, 40-O-[2-(2-Hydroxy)ethoxy]ethyl-rapamycin, 40-O-[(3S)-2,2-Dimethyldioxolan-3-yl]methyl-rapamycin, 40-O-[(2S)-2,3-Dihydroxyprop-1-yl]-rapamycin, 40-O-(2-Acetoxy)ethyl-rapamycin, 40-O-(2-Nicotinoyloxy)ethyl-rapamycin, 40-O-[2-(N-Morpholino)acetoxy]ethyl-rapamycin, 40-O-(2-N-Imidazolylacetoxy)ethyl-rapamycin, 40-O-[2-(N Methyl-N′-piperazinyl)acetoxy]ethyl-rapamycin, 39-O-Desmethyl-39,40-O,O-ethylene-rapamycin, (26R)-26-Dihydro-40-O-(2-hydroxy)ethyl-rapamycin, 28-O-Methyl-rapamycin, 40-O-(2-Aminoethyl)-rapamycin, 40-O-(2-Acetaminoethyl)-rapamycin, 40-O-(2-Nicotinamidoethyl) rapamycin, 40-O-(2-(N-Methyl-imidazo-2′-ylcarbethoxamido)ethyl)-rapamycin, 40-O-(2-Ethoxycarbonylaminoethyl)-rapamycin, 40-O-(2-Tolylsulfonamidoethyl)-rapamycin, 40-O-[2-(4′,5′ Dicarboethoxy-1′,2′,3′-triazol-1′-yl)-ethyl]-rapamycin, 42-Epi-tetrazolyl)rapamycin (tacrolimus), and 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin (temsirolimus). 13. The method of claim 11 further comprising depositing one or more active agents in dry powder form and sintering said plurality of layers under conditions that do not substantially modify the morphology of said one or more active agents. 14. A laminate coronary stent prepared by the method of claim 1. 15. A method of preparing a laminate coronary stent comprising: a. providing a stent framework having a plurality of struts, each strut having a luminal, abluminal and side wall surfaces;b. depositing a plurality of layers on the luminal, abluminal and side wall surfaces of each strut of said stent framework to form a coating, wherein forming the coating comprises the following steps:i. discharging a crystalline pharmaceutical agent or an active biological agent in dry powder form through a first orifice;ii. forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and a first polymer and discharging said supercritical or near supercritical fluid solution through said first orifice or through a second orifice under conditions sufficient to form solid particles of the first polymer;iii. depositing the first polymer and the pharmaceutical agent or the active biological agent particles onto said framework, wherein an electrical potential is maintained between the framework and the first polymer and the pharmaceutical agent or the active biological agent particles;iv. sintering the first polymer under conditions that do not substantially modify the morphology of the pharmaceutical agent or the activity of the biological agent;V. forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and a second polymer and discharging said supercritical or near supercritical fluid solution through said first orifice or through a second orifice under conditions sufficient to form solid particles of the second polymer;iii. depositing the second polymer onto said framework, wherein an electrical potential is maintained between the framework and the second polymer and the pharmaceutical agent or the active biological agent particles;iv. sintering the second polymer under conditions that do not substantially modify the morphology of the pharmaceutical agent or the activity of the biological agent;wherein the coating consists essentially of the first and second polymers and the pharmaceutical agent or the active biological agent, and wherein at least one internal layer comprises at least one pharmaceutical agent and/or active biological agent;and the stent framework has a thickness of about 50% or less of a thickness of the laminate coronary stent. 16. The method of claim 15, wherein the first and second polymers are different.
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Fenster, Aaron; Downey, Donal B., 3D ultrasound-guided intraoperative prostate brachytherapy.
Roby Mark S. (Killingworth CT) Bennett Steven L. (New Haven CT) Liu Cheng-Kung (Norwalk CT), Absorbable block copolymers and surgical articles fabricated therefrom.
Krezanoski Joseph Z. (Los Altos CA), Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery t.
Wang James C. (Norton) Roberts George R. (Arlington) Pederson ; Sr. Brian A. (So. Attleboro MA), Co-extruded medical balloons and catheter using such balloons.
Fearnot Neal E. (West Lafayette IN) Kozma Thomas G. (West Lafayette IN) Ragheb Anthony O. (West Lafayette IN) Voorhees William D. (West Lafayette IN), Coated implantable medical device.
McKearn, John P.; Gordon, Gary; Cunningham, James J.; Gately, Stephen T.; Koki, Alane T.; Masferrer, Jaime L., Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent.
Liu Cheng-Kung (Norwalk CT) Jiang Ying (North Haven CT) Roby Mark S. (Killingworth CT) Bennett Steven L. (New Haven CT) Stevenson Richard P. (Colchester CT) Pietrangeli Jeffrey P. (Bridgeport CT), Composite bioabsorbable materials and surgical articles made therefrom.
Loscalzo, Joseph; Vita, Joseph A.; Loberg, Michael D.; Worcel, Manuel, Composition for treating vascular diseases characterized by nitric oxide insufficiency.
Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
Appel, Leah E.; Curatolo, William J.; Herbig, Scott M.; Nightingale, James A. S.; Thombre, Avinash G., Controlled release by extrusion of solid amorphous dispersions of drugs.
Chandrashekar Bhagya L. ; Zhou Mingxing ; Jarr Eileen M. ; Dunn Richard L., Controlled release liquid delivery compositions with low initial drug burst.
Merida A. D'Augustine ; James H. Liu ; Donald C. Harrison, Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections.
Burke,Sandra E.; Cromack,Keith R.; Mack,Matthew; Toner,John L., Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens.
Hoy Kenneth L. (St. Albans WV) Nielsen Kenneth A. (Charleston WV), Electrostatic liquid spray application of coating with supercritical fluids as diluents and spraying from an orifice.
Palmaz, Julio C.; Boyle, Christopher T.; Banas, Christopher E.; Wiseman, Roger W.; Marton, Denes, Endoluminal implantable devices and method of making same.
Francis Moussy ; Donald Kreutzer ; Diane Burgess ; Jeffrey Koberstein ; Fotios Papadimitrakopoulos ; Samuel Huang, Implant coating for control of tissue/implant interactions.
Yoon Seok-Joon,KRX ; Yeo Guw-Dong,KRX ; Kim You-Chan,KRX ; Seo Min-Hyo,KRX ; Pai Chaul-Min,KRX ; Jung Jong-Pyoung,KRX ; Lee Seung-Jin,KRX, Implantable bioresorbable membrane and method for the preparation thereof.
McNaughton Allen D. (Mountain View CA) Albert Stephen B. (Redwood City CA) Furbershaw Gerard A. (Santa Clara CA), Implanting device and implant magazine.
Canham, Leigh T; Barrett, Christopher P; Cox, Timothy I; Wright, Peter J; Bowditch, Andrew P, Implants for administering substances and methods of producing implants.
Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
Fogarty Thomas J. (770 Welch Rd. Palo Alto CA 94305) Finn ; III James C. (Stanford CA) Kinney Thomas B. (Mountain View CA), Inverted balloon catheter having sealed through lumen.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Mistrater Alan B. (Rochester NY) Pietrzykowski ; Jr. Stanley J. (Rochester NY) Klein Alfred O. (Rochester NY) Hendrix Loren E. (Webster NY) Petropoulos Mark C. (Ontario NY) Batt Gary A. (Fairport NY), Mandrel with flared, dish shaped disk and process for using mandrel.
Shaw, Wendy J.; Yonker, Clement R.; Fulton, John L.; Tarasevich, Barbara J.; McClain, James B.; Taylor, Doug, Medical implants and methods of making medical implants.
Whitbourne, Richard J.; Chamberlain, Alexandra M.; Hullihen, Daniel G.; Rosebrough, Scott F.; Calistri-Yeh, Mildred, Medicated stent having multi-layer polymer coating.
Pletcher Timothy Allen ; Datta Pabitra ; Poux Christopher Just ; McCoy Randall Eugene, Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate.
Burnham, Theodore A.; Cha, Sung W.; Walat, Robert H.; Kim, Roland Y.; Anderson, Jere R.; Stevenson, James F.; Suh, Nam P.; Pallaver, Matthew, Method and apparatus for microcellular polymer extrusion.
Lars Lidgren SE; Peter Bengtsson SE; Peter Sj{overscore (o)}vall SE; Bengt Wesslen SE, Method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof.
Luzzi Louis A. ; Needham Thomas E. ; Hossein Zia ; Dondeti Polireddy, Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa.
Anderson Jere R. (Newburyport MA) Jandris Louis J. (Georgetown MA) Barbere Michael D. (Dunstable MA) Murphy Richard T. (Dracut MA 4), Method of making a distensible dilatation balloon using a block copolymer.
McKearn, John P.; Gordon, Gary; Cunningham, James J.; Gately, Stephen T.; Koki, Alane T.; Masferrer, Jaime L., Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia.
DeYoung, James P.; Gross, Stephen M.; Wagner, Mark I.; McClain, James B., Methods and compositions for etch cleaning microelectronic substrates in carbon dioxide.
Roser, Bruce J.; Sanderson, Ian; Kampinga, Jaap; Colaco, Camilo, Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery.
D'Amato, Robert J.; Green, Shawn J.; Swartz, Jr., Glenn M.; Shah, Jamshed H.; Madsen, John, Methods and compositions for treating an ocular neovascular disease.
DeYoung, James P.; McClain, James B.; Gross, Stephen M.; Wagner, Mark I., Methods for transferring supercritical fluids in microelectronic and other industrial processes.
Hossainy, Syed Faiyaz Ahmed; Tang, Yiwen; Askaryar, Homayon; Lin, Qing; Glauser, Thierry, Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices.
Cha Sung W. (Cambridge MA) Suh Nam P. (Sudbury MA) Baldwin Daniel F. (Medford MA) Park Chul B. (Cambridge MA), Microcellular thermoplastic foamed with supercritical fluid.
Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
Tepper, Gary; Pestov, Dmitry; Levit, Natalia; Wnek, Gary, Molecular imprinting of small particles, and production of small particles from solid state reactants.
Beckert, Thomas; Petereit, Hans-Ulrich; Dressman, Jennifer; Rudolph, Markus, Multi-particulate form of medicament, comprising at least two differently coated forms of pellet.
Maxfield MacRae (Plainfield NJ) Christiani Brian R. (Maplewood NJ) Murthy Sanjeeva N. (Neshanic Station NJ) Tuller Harold (Long Valley NJ), Nanocomposites of gamma phase polymers containing inorganic particulate material.
Haslam John L. (Lawrence KS) Higuchi Takeru (Lawrence KS) Mlodozeniec Arthur R. (Lawrence KS), Ophthalmic drug delivery system utilizing thermosetting gels.
Cecchi, Roberto; Croci, Tiziano; Guzzi, Umberto; Marsault, Eric, Phenoxylpropanolamines, method for the production thereof and pharmaceutical compositions containing the same.
Raeder-Devens, Jennifer E.; Shelso, Susan I.; Hemerick, James F.; Schneider, Eric M.; Getty, Heather L.; Borgmann, Doreen M.; Sisombath, Kakao; Helgerson, Jeffrey A., Prosthesis deployment device with translucent distal end.
Bates, Brian L.; Fearnot, Neal E.; Kozma, Thomas G.; Osborne, Thomas A.; Ragheb, Anthony O.; Roberts, Joseph W.; Voorhees, III, William D., Silver implantable medical device.
Ragheb Anthony O. ; Bates Brian L. ; Fearnot Neal E. ; Osborne Thomas A. ; Kozma Thomas G. ; Roberts Joseph W. ; Voorhees ; III William D., Silver implantable medical device.
Lafont Antoine,FRX ; Vert Michel R.,FRX ; Cornhill Fredrick ; Li Suming,FRX ; Garreau Henri L.,FRX, Stent having a programmed pattern of in vivo degradation.
Fulton, John L.; Deverman, George S.; Matson, Dean W.; Yonker, Clement R.; Taylor, C. Douglas; McClain, James B.; Crowley, Joseph M., System and method for enhanced electrostatic deposition and surface coatings.
Setterstrom Jean A. ; Van Hamont John E. ; Reid Robert H. ; Jacob Elliot ; Jeyanthi Ramasubbu ; Boedeker Edgar C. ; McQueen Charles E. ; Jarboe Daniel L. ; Cassels Frederick ; Brown William ; Thies C, Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix.
Tsukashima Ross (San Diego CA) Jordan Matthew (Los Angeles CA) Jung Gordon (San Diego CA), Tri-fold balloon for dilatation catheter and related method.
Rodrigues Jose,FRX ; Belmain Daniel,FRX ; Barlet Thierry,FRX, Triboelectric projector, installation for projecting coating product and process for controlling such a projector.
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