Amniotic membrane preparations and purified compositions and anti-inflammation methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/50
A61K-009/00
A61K-031/738
A61L-015/50
A61L-015/44
A61K-035/48
A61K-038/17
A61K-038/39
A61K-038/48
C07K-014/47
C07K-014/78
C07K-014/81
A61K-009/06
A61K-009/08
A61L-015/40
출원번호
US-0848153
(2015-09-08)
등록번호
US-9750771
(2017-09-05)
발명자
/ 주소
Tseng, Scheffer
He, Hua
Li, Wei
출원인 / 주소
TISSUETECH, INC.
대리인 / 주소
Wilson Sonsini Goodrich & Rosati
인용정보
피인용 횟수 :
0인용 특허 :
96
초록▼
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtai
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
대표청구항▼
1. A method of reducing inflammation in a subject in need thereof, comprising administering to the subject a composition comprising a water-soluble extract of amniotic membrane from frozen or previously frozen placenta, wherein the water-soluble extract comprises tumor necrosis factor-stimulated gen
1. A method of reducing inflammation in a subject in need thereof, comprising administering to the subject a composition comprising a water-soluble extract of amniotic membrane from frozen or previously frozen placenta, wherein the water-soluble extract comprises tumor necrosis factor-stimulated gene 6 (TSG-6), pentraxin (PTX-3), thrombospondin (TSP-1), and cross-linked high molecular weight hyaluronan (HA). 2. The method of claim 1, wherein the subject has inflammation associated with vascular diseases, migraine headaches, tension headaches, periarteritis nodosa, thyroiditis, aplastic anemia, Hodgkin's disease, scleroderma, rheumatic fever, type I diabetes, myasthenia gravis, sarcoidosis, nephrotic syndrome, Behcet's syndrome, polymyositis, gingivitis, hypersensitivity, conjunctivitis, ischemia, a brain disorder, Parkinson's disease, Alzheimer's disease, chronic inflammation associated with cranial radiation injury, acute inflammatory conditions resulting from infection, chronic inflammatory conditions resulting from asthma, or inflammation associated with trauma. 3. The method of claim 1, wherein the subject has an inflammatory disorder. 4. The method of claim 3, wherein the inflammatory disorder is arthritis, asthma, atherosclerosis, osteoporosis, bronchitis, tendonitis, bursitis, a skin inflammation disorder, enuresis, eosinophilic disease, a gastrointestinal disorder, or non-cardiac chest pain. 5. The method of claim 4, wherein the arthritis is rheumatoid arthritis, osteoarthritis, spondyloarthopathy, gouty arthritis, degenerative joint disease, systemic lupus erythematosus, Sjogren's syndrome, ankylosing spondylitis, undifferentiated spondylitis, Behcet's disease, haemolytic autoimmune anaemia, multiple sclerosis, amyotrophic lateral sclerosis, amylosis, acute painful shoulder, psoriatic, or juvenile arthritis. 6. The method of claim 4, wherein the skin inflammation disorder is psoriasis, eczema, burns, or dermatitis; or the gastrointestinal disorder is inflammatory bowel disease, peptic ulcers, regional enteritis, diverticulitis, gastrointestinal bleeding, Crohn's disease, gastritis, diarrhea, irritable bowel syndrome, ulcerative colitis, gastroesophageal reflux disease, eosinophilic esophagitis, gastroparesis, non-ulcerative dyspepsia, or additional food intolerances and food allergies related bowel disorders. 7. The method of claim 1, wherein the subject has arthritis. 8. The method of claim 1, wherein the extract further comprises Smad7. 9. The method of claim 1, wherein the composition further comprises a pharmaceutically acceptable diluent, excipient, carrier, or combination thereof. 10. The method of claim 9, wherein the composition is formulated as a non-solid dosage form, a solution, drops, suspension, aerosol, paste, spray, ointment, oil, emulsion, cream, lotion, gel, a coated bandage, a patch, sticks, balms, or shampoo. 11. The method of claim 9, wherein the composition is formulated for ophthalmic administration, systemic administration, or topical administration. 12. The method of claim 9, wherein the composition is formulated for intraocular injection, subretinal injection, intravitreal injection, periocular injection, subconjuctival injection, retrobulbar injection, intracameral injection, sub-Tenon's injection, implantation, ocular implantation, or ocular insertion. 13. The method of claim 9, wherein the composition further comprises a penetration enhancer and an aqueous adjuvant. 14. The method of claim 9, wherein the composition is formulated as a solid dosage form. 15. The method of claim 9, wherein the composition is formulated for controlled release.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (96)
Lee Ping I. (Berwyn PA), Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentrati.
Urquhart John (Palo Alto CA) Chandrasekaran Santosh Kumar (Palo Alto CA) Shaw Jane Elizabeth (Atherton CA), Bandage for transdermally administering scopolamine to prevent nausea.
Wisniewski, Hans-Georg; Cowman, Mary K.; Band, Philip, Biocompatible materials containing stable complexes method of TSG-6 and hyaluronan and method of using same.
Schlameus Herman W. (San Antonio TX) Fox William C. (San Antonio TX) Mangold Donald J. (San Antonio TX) Triplett Robert G. (Dallas TX) Holt George R. (San Antonio TX) Aufdemorte Thomas B. (Lakeway TX, Composition and method of promoting hard tissue healing.
Kris P. Antonsen ; Rajiv Nayar ; Wei Wang ; Margaret Caudle ; Michael A. Shearer ; Neville M. Concessio, Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations.
Dansereau Richard J. (Sherburne NY) Mosher Russell Y. (Norwich NY) Axelrod Douglas W. (Norwich NY) Sietsema William K. (Norwich NY), Dosage forms of risedronate.
Brown Karen K. (Kansas City MO) Greene Nathan D. (Leawood KS) Trump Sandy L. (DeSoto KS) Bryant Sharon A. (Shawnee KS), Low viscosity high molecular weight filter sterilizable hyaluronic acid.
Chandrasekaran Santosh Kumar (Palo Alto CA) Urquhart John (Palo Alto CA) Shaw Jane Elizabeth (Atherton CA), Method and therapeutic system for providing chemotherapy transdermally.
Czarniecki Christine W. (San Francisco CA) Palladino Michael A. (Foster City CA) Shefter Eli (San Francisco CA), Method for the treatment of grafts prior to transplantation using TGF-b
상세보기
Bouck Noel P. (Oak Park) Polverini Peter J. (Evanston) Good Deborah J. (Chicago IL) Rastinejad Farzan (Los Altos CA), Method of inhibiting angiogenesis of tumors.
Tayot Jean-Louis (La Tour de Salvagny FRX) Tardy Michel (Lyons FRX), New preparation of placenta collagen, their extraction method and their applications.
Radebaugh Galen W. (Maple Glen PA) Murtha John L. (Holland PA) Glinecke Robert (Glenside PA), Oral sustained release acetaminophen formulation and process.
Kelm Gary Robert (Cincinnati OH) Manring Gary Lee (Hamilton OH), Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery.
Burgeson Robnert E. (Boston OR MA) Lunstrum Gregory P. (Portland OR) Rousselle Patricia (Lyons OR FRX) Keene Douglas R. (Portland OR) Marinkovich M. Peter (Beaverton OR), Product and method for improving keratinocyte adhesion to the dermis.
Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX) Yamashita Gentaro (Koganei JPX), Slow-releasing medical preparation to be administered by adhering to a wet mucous surface.
Phillips Richard E. (San Marcos TX) Moore Mark A. (Austin TX) Russell Ruth L. (Long Beach CA) Cheung David (Arcadia CA), Sterilization of tissue implants using iodine.
Chandrasekaran Santosh K. (Palo Alto CA) Darda Siegfried (Ingelheim am Rhein CA DEX) Michaels Alan S. (Atherton CA) Cleary Gary W. (Palo Alto CA), Therapeutic system for administering clonidine transdermally.
Davis Roosevelt (27 Lullwater Estate Rd. Atlanta GA 30307) Primo-Davis Susan A. (27 Lullwater Estate Rd. Atlanta GA 30307), Transdermal therapeutic formulation.
Milan Adam,CZX ; Eggersgluss Bernd,DEX ; Braumer Klaus,DEX ; Schrieber Reinhard,DEX, Use of tasteless, hydrolyzed collagen and agent containing the same.
Fox ; Jr. Charles L. (Sherman CT) Modak Shanta M. (River Edge NJ) Fox Paul (Valhalla NY), Wound dressing comprising silver sulfadiazine incorporated in animal tissue and method of preparation.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.