Integrated strontium-rubidium radioisotope infusion systems
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/00
A61B-050/13
A61M-005/14
A61M-005/145
A61M-005/168
A61M-005/36
G21F-007/00
G21G-001/00
G21G-004/08
G06F-019/00
A61B-050/10
출원번호
US-0490484
(2017-04-18)
등록번호
US-9750870
(2017-09-05)
발명자
/ 주소
Hidem, Stephen E.
Fontaine, Aaron M.
Gelbach, Janet L.
McDonald, Patrick M.
Hunter, Kathryn M.
Swenson, Rolf E.
Zodda, Julius P.
출원인 / 주소
Bracco Diagnostics, Inc.
대리인 / 주소
Fredrikson & Byron, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
97
초록▼
Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for
Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
대표청구항▼
1. A method of using an infusion system on-board a cart to deliver a rubidium radioactive eluate comprising: installing a saline reservoir on the infusion system, wherein the infusion system comprises a platform and an exterior shell extending upwardly above the platform, and wherein the platform an
1. A method of using an infusion system on-board a cart to deliver a rubidium radioactive eluate comprising: installing a saline reservoir on the infusion system, wherein the infusion system comprises a platform and an exterior shell extending upwardly above the platform, and wherein the platform and the exterior shell collectively define an interior space of a cabinet structure;placing the saline reservoir in fluid communication through a saline tubing line with an inlet tubing port of a strontium-rubidium radioisotope generator located in a first shielding compartment in the interior space of the cabinet structure, wherein the strontium-rubidium radioisotope generator further comprises an outlet tubing port configured to discharge the rubidium radioactive eluate, and wherein the first shielding compartment has a first opening facing vertically upwardly;inserting a waste bottle into a second shielding compartment on-board the cart, wherein the second shielding compartment on-board the cart has a second opening facing vertically upwardly and being at a higher elevation than the first opening;placing the waste bottle in fluid communication with the outlet tubing port of the strontium-rubidium radioisotope generator through an eluate tubing line, wherein a computer on-board the cart is configured to control the fluid communication between the waste bottle and the outlet tubing port, and wherein the computer has a touch screen display mounted on a vertical post with a top end extending above the cabinet structure;inserting an eluate reservoir in a shielded well on-board the cart;placing the eluate reservoir in fluid communication with the eluate tubing line, wherein the computer is further configured to control the fluid communication between the eluate reservoir and the eluate tubing line;pumping a sample of the rubidium radioactive eluate into the eluate reservoir in the shielded well on-board the cart;measuring a radioactivity of the sample of the rubidium radioactive eluate flowing through the eluate tubing line with a radioactivity detector on-board the cart while the sample of the rubidium radioactive eluate is flowing through the eluate tubing line;measuring a calibration radioactivity of the sample pumped into the eluate reservoir in the shielded well on-board the cart while the eluate reservoir remains in the shielded well on-board the cart;comparing the radioactivity of the sample of the rubidium radioactive eluate flowing through the eluate tubing line measured by the radioactivity detector on-board the cart while the sample of the rubidium radioactive eluate is flowing through the eluate tubing line with the calibration radioactivity of the sample pumped into the eluate reservoir in the shielded well on-board the cart; anddetermining a strontium breakthrough test result on the sample pumped into the eluate reservoir in the shielded well on-board the cart while the eluate reservoir remains in the shielded well on-board the cart, wherein the computer of the infusion system is further configured to not allow a patient infusion if the strontium breakthrough test result is greater than or equal to an allowed limit. 2. The method of claim 1, further comprising: placing the eluate tubing line in fluid communication with a patient, wherein the computer is further configured to control the fluid communication between the eluate tubing line and the patient;pumping a dose of the rubidium radioactive eluate to the patient; andflushing the rubidium radioactive eluate remaining in at least a portion of the eluate tubing line into the patient by pumping saline from the saline reservoir to the eluate tubing line through a by-pass line that by-passes the strontium-rubidium radioisotope generator, wherein the computer is further configured to control fluid communication via the by-pass line. 3. The method of claim 2, further comprising: logging into the computer by entering a user login credential on the touch screen display,transferring a patient infusion record via a USB port, andprinting a document concerning the patient infusion or a quality control test result via a printer. 4. The method of claim 2, further comprising: initiating a purging process through the touch screen display to purge a patient tubing line of air, wherein the patient tubing line is in fluid communication with the eluate tubing line. 5. The method of claim 2, wherein the computer of the infusion system is further configured to present on the touch screen display a screen reminding a user to insert the eluate reservoir in the shielded well on-board the cart. 6. The method of claim 2, wherein the computer of the infusion system is further configured to present on the touch screen display a screen for starting the patient infusion by touching a button on the touch screen display. 7. The method of claim 2, wherein the computer of the infusion system is further configured to present on the touch screen display a screen indicating that the patient infusion is in process, wherein the screen indicating that the patient infusion is in process displays a stop button to abort the patient infusion. 8. The method of claim 2, wherein the computer of the infusion system is further configured to: present on the touch screen display a screen for starting the patient infusion by touching a button on the touch screen display;present on the touch screen display a screen reminding a user to insert the eluate reservoir in the shielded well on-board the cart;present on the touch screen display a screen indicating that the patient infusion is in process, wherein the screen indicating that the patient infusion is in process displays a stop button to abort the patient infusion; andpresent on the touch screen display the strontium breakthrough test result. 9. The method of claim 8, further comprising: logging into the computer by entering a user login credential on the touch screen display,entering a patient ID on the touch screen display,entering a patient dose on the touch screen display, andentering a flow rate on the touch screen display. 10. The method of claim 9, wherein the computer of the infusion system is further configured to: track a volume of saline remaining in the saline reservoir,provide an alert via the touch screen display when the volume of saline remaining in the saline reservoir is below a predetermined volume threshold,andpresent on the touch screen display a screen reminding the user to empty the waste bottle. 11. The method of claim 10, further comprising: initiating a generator column wash through the touch screen display, wherein a predetermined amount of saline is pumped through the strontium-rubidium radioisotope generator and directed to the waste bottle during the generator column wash, andinitiating a purging process through the touch screen display to purge a patient tubing line of air, wherein the patient tubing line is in fluid communication with the eluate tubing line. 12. The method of claim 11, wherein the saline tubing line and the eluate tubing line are routed through two tubing passageways formed in a perimeter surface of the first opening, wherein each of the two tubing passageways has a depth configured to prevent pinching or crushing of a corresponding tubing line routed therethrough when a first door is closed over the first opening. 13. The method of claim 12, wherein the infusion system further comprises: a handle configured for the user to grasp in order to move the infusion system, andfour wheels mounted to an underside of the platform of the cabinet structure. 14. The method of claim 13, wherein the computer of the infusion system is further configured to: project a first light signal from a light projector mounted on the top end of the vertical post extending above the cabinet structure to indicate that an elution is taking place, andproject a second light signal from the light projector to indicate that a peak bolus of radioactivity is detected. 15. The method of claim 14, wherein the cabinet structure has a lowermost portion and the platform has a lower surface,the first opening is at a first elevation,the second opening is at a second elevation,the first elevation is between approximately 1 foot and approximately 2 feet, with respect to the lowermost portion of the cabinet structure, andthe second elevation is between approximately 2 feet and approximately 3 feet, with respect to the lower surface of the platform. 16. The method of claim 13, wherein the infusion system further comprises a dose calibrator in the shielded well on-board the cart and in communication with the computer to determine the strontium breakthrough test result. 17. The method of claim 16, wherein the cabinet structure has a lowermost portion and the platform has a lower surface,the first opening is at a first elevation,the second opening is at a second elevation,the first elevation is between approximately 1 foot and approximately 2 feet, with respect to the lowermost portion of the cabinet structure, andthe second elevation is between approximately 2 feet and approximately 3 feet, with respect to the lower surface of the platform. 18. The method of claim 1, wherein the computer of the infusion system is further configured to present on the touch screen display the strontium breakthrough test result. 19. The method of claim 1, wherein the cabinet structure has a lowermost portion and the platform has a lower surface,the first opening is at a first elevation,the second opening is at a second elevation,the first elevation is between approximately 1 foot and approximately 2 feet, with respect to the lowermost portion of the cabinet structure, andthe second elevation is between approximately 2 feet and approximately 3 feet, with respect to the lower surface of the platform. 20. The method of claim 1, wherein the saline tubing line and the eluate tubing line are routed through two tubing passageways formed in a perimeter surface of the first opening, wherein each of the two tubing passageways has a depth configured to prevent pinching or crushing of a corresponding tubing line routed therethrough when a first door is closed over the first opening. 21. The method of claim 1, wherein the infusion system further comprises a dose calibrator in the shielded well on-board the cart, wherein the dose calibrator is in communication with the computer to determine the strontium breakthrough test result. 22. The method of claim 1, wherein the computer of the infusion system is further configured to: track a volume of saline remaining in the saline reservoir, andprovide an alert via the touch screen display when the volume of saline remaining in the saline reservoir is below a predetermined volume threshold. 23. The method of claim 1, wherein the computer of the infusion system is further configured to: track a volume of the rubidium radioactive eluate discharged from the strontium-rubidium radioisotope generator to the waste bottle, andpresent on the touch screen display a screen reminding a user to empty the waste bottle. 24. The method of claim 1, wherein the computer of the infusion system is further configured to: project a first light signal from a light projector mounted on the top end of the vertical post extending above the cabinet structure to indicate that an elution is taking place, andproject a second light signal from the light projector to indicate that a peak bolus of radioactivity is detected. 25. The method of claim 1, wherein the computer of the infusion system is further configured to pump saline through the strontium-rubidium radioisotope generator at a rate less than approximately 70 ml/min. 26. The method of claim 1, further comprising: initiating a generator column wash through the touch screen display, wherein a predetermined amount of saline is pumped through the strontium-rubidium radioisotope generator and directed to the waste bottle during the generator column wash. 27. The method of claim 1, wherein the computer of the infusion system is further configured to track time passed from completion of pumping the sample of the rubidium radioactive eluate into the eluate reservoir to determining the strontium breakthrough test result. 28. The method of claim 1, further comprising: entering a patient ID on the touch screen display,entering a patient dose on the touch screen display, andentering a flow rate on the touch screen display. 29. The method of claim 1, wherein the saline reservoir is located outside of the interior space of the cabinet structure. 30. The method of claim 1, wherein the infusion system further comprises: a handle configured for a user to grasp in order to move the infusion system, andfour wheels mounted to an underside of the platform of the cabinet structure.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (97)
Neirinckx Rudi D. (East Windsor NJ) Loberg Michael D. (Princeton NJ), 82Rb Generating method and eluent.
Bradshaw Anthony J. (Missouri City TX) Thornton Richard T. (League City TX) Hayman Michael H. (New Orleans LA), Apparatus and method for the remote handling of highly radioactive sources in the treatment of cancer.
Sonnenhol, Julian Bernd; Eursch, Andreas; Harfensteller, Mark; Schilp, Michael; Buck, Oliver; Ehrenfried, Lisa Maria; Nikula, Tuomo, Apparatus for and method of preparing a small amount of a radioactive substance combination.
Quirico, Charles R.; Balestracci, Ernest; Childs, Jacob S.; Madson, Peter B.; Clements, Daniel V.; Gelbach, Janet L., Cabinet structure configurations for infusion systems.
Balestracci, Ernest; Melchore, Jr., James A.; Monteferrante, Jo Anna; Kucharewicz Ropiak, Irene; Schramm, Ernst; Zodda, Julius P.; Quirico, Charles R., Containers for pharmaceuticals, particularly for use in radioisotope generators.
Reilly, David M.; Hirschman, Alan D.; Griffiths, David M.; Crookston, Currie, Delivery methods, systems and components for use with hazardous pharmaceutical substances.
Reilly,David M.; Hirschman,Alan D.; Griffiths,David M.; Crookston,Currie, Delivery methods, systems and components for use with hazardous pharmaceutical substances.
Kenley Rodney S. (Libertyville IL) Matthews Dawn (Grayslake IL) Wilkerson Douglas L. (Gurnee IL) Treu Dennis M. (Gurnee IL) Peter ; Jr. Frederick H. (Barrington IL) Brose Tom L. (Gurnee IL) Feldsein , Filter integrity test method for dialysis machines.
Ford Alan D. (Concord NH) Sims Nathaniel M. (Wellesley Hills MA) Mandro Marc A. (Bow NH), Infusion pump with an electronically loadable drug library and a user interface for loading the library.
Jeppsson Jan-Bertil,SEX ; Thell Bengt-Olov,SEX, Method and arrangement for integrity-testing of a tube-set for use in a cycler for peritoneal dialysis.
Shefer Ruth E. (Newton MA) Klinkowstein Robert E. (Winchester MA) Hughey Barbara J. (Lexington MA) Welch Michael J. (St. Louis MO) Dence Carmen S. (St. Louis MO), Method for producing radioisotopes.
Wells Charles P. (Canterbury GB2) Kettle Andrew G. (Margate GB2), Method of conveying liquid materials and device for the automated elution of a radionuclidic generator.
Herscheid Jacobus D. M. (Nieuw Vennep NLX) Van Roojj Leo F. (Amstelveen NLX), Method of preparing a radiodiagnostic comprising a gaseous radionuclide, as well as a radionuclide generator suitable fo.
Brooker Michael J. ; Frye John E. ; Kotnik Paul T. ; Mosholder Michael B. ; Placke Michael E. ; Zimlich ; Jr. William C., Pulmonary dosing system and method.
Holdsworth David W. (London CAX) Drangova Maria (London CAX) Fenster Aaron (London CAX), Pulse-injector for quantitative angiographic blood-flow measurements.
Moller,Teresia; Adams,Todd; Cisar,Alan; Gali,Hariprasad; Sylvester,Paul, Rubidium-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets.
Sylvester, Paul, Rubidlum-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets.
Bryant Cal L. (Bartlet IL) Parrish Charles A. (New Holland PA) Griffin ; Jr. B. Franklin (Alexandria VA), Semi-automatic baler control and indicator system.
Quirico, Charles R.; Balestracci, Ernest; Darst, Daniel; Krause, Eric J.; Lokhande, Vishal N.; Childs, Jacob S.; Madson, Peter B.; Clements, Daniel V., Shielding assemblies for infusion systems.
Kroll Mark W. (Minnetonka MN) Pommrehn Mark R. (Eden Prairie MN), System for remotely authorizing operation of a device and for automatically generating an invoice based on device usage.
Casale, Guillermo Arturo; Nicolini, Jorge Osvaldo; Kock, Elvira Calvo, System for the control, verification and recording of the performance of a radioisotope generator's operations.
Dhawale, Paritosh Jayant; Jackson, Mark Alan; Lara, Hernan Rodrigo; Brussermann, Michael; Ketzscher, Ulrich, Systems, methods and apparatus for preparation, delivery and monitoring of radioisotopes in positron emission tomography.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.