Method for formulating large diameter synthetic membrane vesicles
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01J-013/04
A61K-009/127
B01D-001/16
A61K-031/4458
B01F-003/08
B01F-005/10
B01F-007/00
A61K-009/48
A61M-011/00
B01J-013/12
A61K-031/445
B01F-003/04
B01F-015/06
출원번호
US-0786945
(2013-03-06)
등록번호
US-9757336
(2017-09-12)
발명자
/ 주소
Schutt, Ernest George
McGuire, Ronald Warren
Walters, Peter Andrew
Los, Kathleen D. A.
출원인 / 주소
Pacira Pharmaceuticals, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear, LLP
인용정보
피인용 횟수 :
0인용 특허 :
172
초록▼
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
대표청구항▼
1. A process for making multivesicular liposomes using an atomizing nozzle apparatus, wherein the apparatus comprises: a first fluid conduit and a second fluid conduit each having at least one entrance orifice and at least one exit orifice;a fluid contacting chamber having a top comprising at least
1. A process for making multivesicular liposomes using an atomizing nozzle apparatus, wherein the apparatus comprises: a first fluid conduit and a second fluid conduit each having at least one entrance orifice and at least one exit orifice;a fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and connecting to the at least one exit orifice of the first fluid conduit, wherein the fluid contacting chamber conically narrows in diameter from the top of the fluid contacting chamber to the exit orifice of the fluid contacting chamber; anda third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the fluid contacting chamber,wherein the process for making multivesicular liposomes comprises:applying a first liquid to the first fluid conduit, wherein the first liquid comprises an organic solvent;applying a second liquid to the second fluid conduit;applying a pressurized gas to the third fluid conduit to provide atomized droplets, wherein the pressurized gas exiting the third fluid conduit exit orifice impinges the liquid exiting the fluid contacting chamber exit orifice; andremoving the organic solvent from the atomized droplets, wherein less than 4000 ppm of the organic solvent remains in the atomized droplets, resulting in formation of multivesicular liposomes. 2. The process of claim 1, wherein the first liquid is an emulsion comprised of: a discontinuous aqueous phase; anda continuous organic phase comprising the organic solvent. 3. The process of claim 2, wherein the organic solvent is methylene chloride or chloroform. 4. The process of claim 2, wherein the discontinuous aqueous phase further comprises a therapeutic agent. 5. The process of claim 2, wherein the continuous organic phase further comprises a therapeutic agent. 6. The process of claim 5, wherein the therapeutic agent is bupivacaine or a salt thereof. 7. The process of claim 1, wherein the second liquid applied to the second fluid conduit is an aqueous solution. 8. The process of claim 7, wherein the aqueous solution further comprises either dextrose or lysine, or a mixture thereof. 9. The process of claim 1, wherein the gas is a sterilized gas. 10. The process of claim 9, wherein the sterilized gas is nitrogen. 11. The process of claim 1, wherein the atomized droplets contain organic solvent in the range of from about 400 ppm to about 3500 ppm after solvent removal. 12. The process of claim 4, wherein the therapeutic agent is bupivacaine or a salt thereof. 13. A process for making multivesicular liposomes using an evaporation apparatus comprising, wherein the evaporation apparatus comprises: a solvent removal vessel having a top, a bottom, and a circular wall,at least one atomizing nozzle,at least one carrier gas entrance orifice,a solvent removal gas exit orifice centrally connected to the top, anda product exit orifice connected to the bottom of the vessel;wherein the at least one atomizing nozzle comprises: a first fluid conduit a second fluid conduit each having at least one entrance orifice and at least one exit orifice;a fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and connecting to the at least one exit orifice of the first fluid conduit, wherein the fluid contacting chamber conically narrows in diameter from the top of the fluid contacting chamber to the exit orifice of the fluid contacting chamber; anda third fluid conduit, wherein the third fluid conduit annularly surrounds a portion of the fluid contacting chamber,wherein the process for making multivesicular liposomes comprises:applying a first liquid to the first fluid conduit, wherein the first liquid comprises an organic solvent;applying a second liquid to the second fluid conduit;applying a pressurized gas to the third fluid conduit to provide atomized droplets, wherein the pressurized gas exiting the third fluid conduit exit orifice impinges the liquid exiting the fluid contacting chamber exit orifice; andremoving the organic solvent from the atomized droplets wherein the step of removing the organic solvent from the atomized droplets comprises:introducing atomized droplets from the at least one atomizing nozzle into the evaporation apparatus,introducing a pressurized carrier gas tangentially to the circular wall into the solvent removal vessel through one of the at least one carrier gas entrance orifices; andremoving a solvent removal gas wherein the solvent removal gas removes greater than 90% of the organic solvent in the atomized droplets resulting in formation of multivesicular liposomes. 14. The process of claim 13, wherein the carrier gas is heated and humidified. 15. The process of claim 13, further comprising spraying a wall rinse solution into the solvent removal vessel using a rinse nozzle, wherein the wall rinse solution prevents build-up of particles in the evaporation apparatus.
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Kim In (354-7 Myunmok-Dong ; Dongdaemoon-Ku Seoul KRX) Kim Seo (354-7 Myunmok-Dong ; Dongdaemoon-Ku Seoul KRX), Colloid-active synthetic detergent and process for its manufacture.
Graves ; Jr. George A. (Bellbrook OH) McCullum Dale E. (Vandalia OH) Goodrich Steven M. (Dayton OH), Controlled pore size ceramics particularly for orthopaedic and dental applications.
Lee Fei P. (Novi MI) Guzowski Mike (Canton MI), Fuel injector assembly with first and second fuel injectors and inner, outer, and intermediate air discharge chambers.
Zwiercan Gary A. (Knutsford NJ GB2) Lacourse Norman L. (Plainsboro NJ) Lenchin Julianne M. (Cranbury NJ), Imitation cheese products containing high amylose starch as total caseinate replacement.
Bolotin Elijah M. ; Grant Gilbert J. ; Barenholz Yechezkel,ILX ; Turndorf Herman ; Piskoun Boris, Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient.
Damgaard-Iversen Jorgen (Birkerod DK) Gude Klaus Erik (Vedbaek DK) Hansen Ove Emil (Vaerlose DK) Lund Bjorn (Frederiksberg DK) Petersen Mogens (Lyngby DK), Method and apparatus for evaporating liquid.
Lundquist ; Jr. Joseph Theodore (Ellicott City MD) Veltman Preston Leonard (Severna Park MD) Woodruff Edward Theodore (Woodbine MD), Method for drying fructose solutions.
Arndt Peter J. (Seeheim-Jugenheim DEX) Wenzel Franz (Darmstadt DEX) Mller Manfred (Rossdorf DEX) Schlosser Fritz (Darmstadt DEX), Method for isolating vinyl salt compounds from aqueous solutions.
Katcher Jay H. (Cranbury NJ) Mabon John T. (Andover MA) Matherly Jennifer W. (Cherry Hill NJ) McCarty Lawrence T. (Dover DE) Schara Robert E. (Princeton Junction NJ), Method for pregelatinized, spray-dried starch agglomerates.
Kalka Josef (Herten DT) Winter Hermann (Marl DT) Smolinski Manfred (Marl DT) Wolf Hans-Georg (Marl DT), Method for preparing synthetic powders based on polyvinyl chloride or vinyl chloride copolymers containing emulsifiers.
Netting David I. (Springfield PA) Hertzenberg Elliot P. (Wilmington DE), Method of preparing modified hollow, largely spherical particles by spray drying.
Swarr Thomas E. (South Windsor CT) Nickols Richard C. (East Hartford CT) Krasij Myron (Avon CT), Method of preparing thin porous sheets of ceramic material.
Chickering, III, Donald E.; Narasimhan, Sridhar; Altreuter, David; Kopesky, Paul; Keegan, Mark; Straub, Julie A.; Bernstein, Howard, Methods and apparatus for making particles using spray dryer and in-line jet mill.
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Cassani Giovanni Rodolfo (Pavia ITX) Lani Marina Barbara (Lesmo ITX), Mobile-module plant for the development and the production of biotechnological products on a pilot scale.
Kim Sinil ; Howell Stephen B., Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride.
Kim Sinil ; Howell Stephen B., Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride.
Salpekar Anil M. (Creve Coeur MO) Freebersyser Steven R. (Florissant MO) Robinson Douglas A. (Creve Coeur MO), N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same.
Veltman Preston L. (212 Old Country Rd. Severna Park MD 21146) Hansen Ove (6560 Walnut Grove Columbia MD 21045), Particulate fuel components for solid propellant systems.
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Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI) Wisniach Joseph T. (Riverview MI), Process for lubricating water-soluble vitamin powders.
Kaczur Jerry J. (Cleveland TN) Deininger J. Paul (Los Alamos NM) Carpenter Larry D. (Cleveland TN), Process for making selected doped barium and strontium hexaferrite particles.
Yamazaki Hiroshi (Nepean CAX) Modler Howard W. (Kemptville CAX) Jones John D. (Ottawa CAX) Elliot James I. (Ottawa CAX), Process for preparing flour from Jerusalem artichoke tubers.
Schara Robert E. (Princeton Junction NJ) Katcher Jay H. (Cranbury NJ), Process for preparing modified, pregelatinized dent cornstarch and product thereof.
Moller Jens C. T. (5245 Hayledge Court Columbia MD 21045) Hansen Ove E. (Skovgards Alle 261 3500 Ll. Vaerlose DK), Process for preparing paraformaldehyde.
Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI) Schmidt Douglass N. (Grosse Ile MI), Process for preparing spray dried acetaminophen powder and the powder prepared thereby.
Schmidt Douglass N. (Grosse Ile MI) Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI), Process for preparing spray-dried powders containing a water-soluble vitamin and powders prepared thereby.
Subramaniam Anandaraman (Syracuse NY) Ozogar Robert M. (Mattydale NY) Bergsbaken Carlton K. (Syracuse NY), Process for preparing “non-bitter”enzyme modified cheese flavoring material and spray dried product.
Kalka Josef (Herten DEX) Winter Hermann (Marl DEX) Kania Alfred (Marl DEX), Process for production of polymers of vinyl chloride for paste preparation using spray-drying.
Seiter Wolfgang (Neuss DEX) Wegener Ingo (Duesseldorf DEX) Reuter Herbert (Hilden DEX), Process for the production of a spray-dried nonionic washing aid.
Brenner Joseph (Middletown NY) Henderson Gary H. (Middletown NY) Bergensten Robert W. (Kerhonkson NY), Process of encapsulating an oil and product produced thereby.
Hensler Paul L. (Lawrence KS) Kelso Frederick J. (Trenton NJ) Wolfe Gary E. (Trenton NJ) Zeh Peter H. (Fremont CA), Production of Phase II sodium tripolyphosphate.
Horn Hans Christoph,DEX ; Kumberger Otto,DEX ; Millies Marco,DEX ; Neth Norbert,DEX ; Popel Wolfgang Jurgen,DEX ; Rieker Christopher William,DEX ; Sprague Michael Jolyon,DEX ; Stroezel Manfred,DEX, Production of solids by precipitation.
Kowalski Werner (Weilerswist DEX) Haas Hans (Swisttal DEX) Dahmen Theo (Brhl DEX) Erpenbach Markus (Cologne DEX), Spheroidal alkali metal polyphosphates of low apparent density, and process for making them.
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Kirkpatrick Paul A. (Jackson NJ) Schulman Marvin (Howell NJ) Lehmann Douglas M. (Howell NJ) Hegadorn Joseph L. (Ridgewood NJ), Three-fluid atomizing nozzle and method of utilization thereof.
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