Methods of inducing anesthesia in a subject by administering an effective amount of a compound or a mixture of compounds according to Formula I are provided. Compounds of Formula I are a class of halogenated alcohol derivatives with a vapor pressure of at least 0.1 atmospheres (76 mmHg) at 25° C. Co
Methods of inducing anesthesia in a subject by administering an effective amount of a compound or a mixture of compounds according to Formula I are provided. Compounds of Formula I are a class of halogenated alcohol derivatives with a vapor pressure of at least 0.1 atmospheres (76 mmHg) at 25° C. Compounds of Formula I can be administered by any route sufficient to achieve a desired anesthetic endpoint.
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1. A method of inducing anesthesia in a subject, comprising administering to the subject via the respiratory system an effective amount of a compound or a mixture of compounds of Formula I: wherein:n is 0-4,R1 is H;R2, R3, R4, R5 and R6 independently are selected from H, X, CX3, CHX2, CH2X and C2X5;
1. A method of inducing anesthesia in a subject, comprising administering to the subject via the respiratory system an effective amount of a compound or a mixture of compounds of Formula I: wherein:n is 0-4,R1 is H;R2, R3, R4, R5 and R6 independently are selected from H, X, CX3, CHX2, CH2X and C2X5; andwherein X is a fluorine, the compound having a vapor pressure of at least 0.1 atmospheres (76 mmHg) at 25° C., and the number of hydrogen atoms in Formula I do not exceed the number of carbon atoms, thereby inducing anesthesia in the subject. 2. The method of claim 1, wherein the compound is selected from the group consisting of: a) 1-Butanol, 4,4,4-trifluoro-3,3-bis(trifluoromethyl)- (CAS#14115-49-2);b) 1-Butanol, 1,1,2,2,3,3,4,4,4-nonafluoro- (CAS#3056-01-7);c) 1-Butanol, 2,2,3,4,4,4-hexafluoro-3-(trifluoromethyl)- (CAS#782390-93-6);d) 1-Butanol, 3,4,4,4-tetrafluoro-3-(trifluoromethyl)- (CAS#90999-87-4);e) 1-Pentanol, 1,1,4,4,5,5,5-heptafluoro- (CAS#313503-66-1); andf) 1-Pentanol, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro- (CAS#57911-98-5). 3. The method of claim 2, wherein the compound is 1-Butanol, 4,4,4-trifluoro-3,3-bis(trifluoromethyl)- (CAS#14115-49-2). 4. The method of claim 2, wherein the compound is 1-Butanol, 1,1,2,2,3,3,4,4,4-nonafluoro- (CAS#3056-01-7). 5. The method of claim 2, wherein the compound is 1-Butanol, 2,2,3,4,4,4-hexafluoro-3-(trifluoromethyl)- (CAS#782390-93-6). 6. The method of claim 2, wherein the compound is 1-Butanol, 3,4,4,4-tetrafluoro-3-(trifluoromethyl)- (CAS#90999-87-4). 7. The method of claim 2, wherein the compound is 1-Pentanol, 1,1,4,4,5,5,5-heptafluoro- (CAS#313503-66-1). 8. The method of claim 2, wherein the compound is 1-Pentanol, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro- (CAS#57911-98-5). 9. The method of claim 2, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint, the desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 10. The method of claim 2, wherein the subject is a mammal. 11. A method of inducing anesthesia in a subject, comprising administering to the subject an effective amount of a compound or a mixture of compounds of Formula I: wherein:n is 0-4,R1 is H;R2, R3, R4, R5 and R6 independently are selected from H, X, CX3, CHX2, CH2X and C2X5; andwherein X is a fluorine, the compound having a vapor pressure of at least 0.1 atmospheres (76 mmHg) at 25° C., and the number of hydrogen atoms in Formula I do not exceed the number of carbon atoms, thereby inducing anesthesia in the subject. 12. The method of claim 11, wherein the compound is selected from the group consisting of: a) 1-Butanol, 4,4,4-trifluoro-3,3-bis(trifluoromethyl)- (CAS#14115-49-2);b) 1-Butanol, 1,1,2,2,3,3,4,4,4-nonafluoro- (CAS#3056-01-7);c) 1-Butanol, 2,2,3,4,4,4-hexafluoro-3-(trifluoromethyl)- (CAS#782390-93-6);d) 1-Butanol, 3,4,4,4-tetrafluoro-3-(trifluoromethyl)- (CAS#90999-87-4);e) 1-Pentanol, 1,1,4,4,5,5,5-heptafluoro- (CAS#313503-66-1); andf) 1-Pentanol, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro- (CAS#57911-98-5). 13. The method of claim 12, wherein the administering comprises administering by any route sufficient to achieve a desired anesthetic effect. 14. The method of claim 13, wherein the compound is 1-Butanol, 4,4,4-trifluoro-3,3-bis(trifluoromethyl)- (CAS#14115-49-2). 15. The method of claim 13, wherein the compound is 1-Butanol, 1,1,2,2,3,3,4,4,4-nonafluoro- (CAS#3056-01-7). 16. The method of claim 13, wherein the compound is 1-Butanol, 2,2,3,4,4,4-hexafluoro-3-(trifluoromethyl)- (CAS#782390-93-6). 17. The method of claim 13, wherein the compound is 1-Butanol, 3,4,4,4-tetrafluoro-3-(trifluoromethyl)- (CAS#90999-87-4). 18. The method of claim 13, wherein the compound is 1-Pentanol, 1,1,4,4,5,5,5-heptafluoro- (CAS#313503-66-1). 19. The method of claim 13, wherein the compound is 1-Pentanol, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro- (CAS#57911-98-5). 20. The method of claim 13, wherein the compound is administered at a dose sufficient to achieve a desired anesthetic endpoint, the desired anesthetic endpoint selected from the group consisting of general anesthesia, sedation, tranquilization, immobility, amnesia, analgesia, unconsciousness and autonomic quiescence. 21. The method of claim 12, wherein the subject is a mammal. 22. The method of claim 1, wherein the mammal is a human. 23. The method of claim 21, wherein the mammal is a human.
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Siegemund ; Gunter ; Muschaweck ; Roman, 1,2,2,2-Tetrafluoroethyl-fluoromethyl ether and process for preparing it.
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