Apparatus and methods are described, including apparatus for pacing a heart of a subject. The apparatus includes an implantable pulse generator (IPG) and a coiled lead connected to the IPG. The coiled lead includes a smaller-diameter coiled portion, a lumen of which having a first coil-lumen-diamete
Apparatus and methods are described, including apparatus for pacing a heart of a subject. The apparatus includes an implantable pulse generator (IPG) and a coiled lead connected to the IPG. The coiled lead includes a smaller-diameter coiled portion, a lumen of which having a first coil-lumen-diameter, and a larger-diameter coiled portion electrically in series with the smaller-diameter coiled portion, a lumen of the larger-diameter coiled portion having a second coil-lumen-diameter that is larger than the first coil-lumen-diameter. A perpendicular distance from a central longitudinal axis of the smaller-diameter coiled portion to the lumen of the larger-diameter coiled portion is greater than an outer radius of the smaller-diameter coiled portion, when the central longitudinal axis of the smaller-diameter coiled portion is parallel to a central longitudinal axis of the larger-diameter coiled portion. Other applications are also described.
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1. Apparatus for pacing a heart of a subject, the apparatus comprising a kit comprising: (a) a first implantable pulse generator (IPG); and(b) a first coiled lead connected to the first IPG, the first coiled lead comprising: a smaller-diameter coiled portion, a lumen of which having a first coillume
1. Apparatus for pacing a heart of a subject, the apparatus comprising a kit comprising: (a) a first implantable pulse generator (IPG); and(b) a first coiled lead connected to the first IPG, the first coiled lead comprising: a smaller-diameter coiled portion, a lumen of which having a first coillumen-diameter; anda larger-diameter coiled portion electrically in series with the smaller-diameter coiled portion, a lumen of the larger-diameter coiled portion having a second coil-lumen-diameter that is larger than the first coil-lumen-diameter, a perpendicular distance from a central longitudinal axis of the smaller-diameter coiled portion to the lumen of the larger-diameter coiled portion being greater than an outer radius of the smaller-diameter coiled portion, when the central longitudinal axis of the smaller-diameter coiled portion is parallel to a central longitudinal axis of the larger-diameter coiled portion;(c) a second IPG, which is not electrically or mechanically coupled to the first IPG when contained inside the kit; and(d) a second coiled lead connected to the second IPG, an outer diameter of the second coiled lead being less than the diameter of the lumen of the larger-diameter coiled portion of the first coiled lead,wherein when a portion of the second coiled lead is aligned with respect to the larger-diameter coiled portion of the first coiled lead such that a central longitudinal axis of the portion of the second coiled lead passes longitudinally through the larger-diameter coiled portion of the first coiled lead: one of the first and the second IPGs is configured to generate a first pacing signal, which passes through its coiled lead and induces a synchronizing signal in the other coiled lead, andthe other one of the first and the second IPGs is configured to receive the synchronizing signal, and generate a second pacing signal in response to the synchronizing signal. 2. The apparatus according to claim 1, wherein a perpendicular distance between: (a) a central longitudinal axis of the first IPG and(b) the central longitudinal axis of the smaller-diameter coiled portion is greater than a perpendicular distance between:(a) the central longitudinal axis of the first IPG and(b) the central longitudinal axis of the larger-diameter coiled portion,when the central longitudinal axis of the first IPG is parallel to (i) the central longitudinal axis of the larger-diameter coiled portion, and (ii) the central longitudinal axis of the smaller-diameter coiled portion. 3. The apparatus according to claim 1, wherein a perpendicular distance between: (a) a central longitudinal axis of the first IPG and(b) the central longitudinal axis of the larger-diameter coiled portion is greater than a perpendicular distance between:(a) the central longitudinal axis of the first IPG and(b) the central longitudinal axis of the smaller-diameter coiled portion,when the central longitudinal axis of the first IPG is parallel to (i) the central longitudinal axis of the larger-diameter coiled portion, and (ii) the central longitudinal axis of the smaller-diameter coiled portion. 4. The apparatus according to claim 1, wherein (i) a central longitudinal axis of the first IPG,(ii) the central longitudinal axis of the smaller-diameter coiled portion, and(iii) the central longitudinal axis of the larger-diameter coiled portion are not all coplanar with each other. 5. The apparatus according to claim 1, wherein a perpendicular distance from a central longitudinal axis of the first IPG to the lumen of the larger-diameter coiled portion is greater than an outer radius of the first IPG, when the first coiled lead is straight. 6. The apparatus according to claim 1, wherein a perpendicular distance from a central longitudinal axis of the first IPG to the lumen of the smaller-diameter coiled portion is greater than an outer radius of the first IPG, when the central longitudinal axis of the first IPG is parallel to the central longitudinal axis of the smaller-diameter coiled portion. 7. The apparatus according to claim 1, wherein the first IPG is shaped to define a channel, a proximal portion of the smaller-diameter coiled portion being disposed within the channel. 8. The apparatus according to claim 1, wherein the smaller-diameter coiled portion is disposed longitudinally between the first IPG and the larger-diameter coiled portion. 9. The apparatus according to claim 8, wherein the smaller-diameter coiled portion is a first smaller-diameter coiled portion,wherein the first coiled lead further comprises a second smaller-diameter coiled portion electrically in series with the larger-diameter coiled portion, a lumen of the second smaller-diameter coiled portion having a diameter that is less than the diameter of the lumen of the larger-diameter coiled portion,wherein the larger-diameter coiled portion is disposed between the first smaller-diameter coiled portion and the second smaller-diameter coiled portion, andwherein a perpendicular distance from a central longitudinal axis of the second smaller-diameter coiled portion to the lumen of the larger-diameter coiled portion is greater than an outer radius of the second smaller-diameter coiled portion, when the central longitudinal axis of the second smaller-diameter coiled portion is parallel to the central longitudinal axis of the larger-diameter coiled portion. 10. The apparatus according to claim 1, wherein the larger-diameter coiled portion is disposed longitudinally between the first IPG and the smaller-diameter coiled portion. 11. The apparatus according to claim 1, further comprising an intravascular stent, the first IPG being coupled to the stent. 12. The apparatus according to claim 1, wherein an outer diameter of the second coiled lead is constant over at least 95% of a length of the second coiled lead. 13. The apparatus according to claim 1, wherein a length of the larger-diameter coiled portion of the first coiled lead is 0.5-5 cm. 14. The apparatus according to claim 13, wherein the length of the larger-diameter coiled portion of the first coiled lead is 1-3 cm. 15. The apparatus according to claim 1, wherein a proximal end of the larger-diameter coiled portion has a funnel-shaped configuration. 16. The apparatus according to claim 15, wherein the proximal end of the larger-diameter coiled portion is configured to have (i) a collapsed configuration when disposed inside of an enclosing lumen, and (ii) the funnel-shaped configuration when not disposed inside of the enclosing lumen. 17. The apparatus according to claim 1, further comprising a flexible longitudinal element passing through the larger-diameter coiled portion. 18. The apparatus according to claim 17, wherein the flexible longitudinal element is shaped as a loop. 19. The apparatus according to claim 1, wherein the first and the second coiled leads are covered by respective non-helical casings. 20. Apparatus for pacing a heart of a subject, the apparatus comprising: an implantable pulse generator (IPG), configured to generate a pacing signal;a coiled lead connected to the IPG, the coiled lead comprising: a smaller-diameter coiled portion, a lumen of which having a first coil-lumen-diameter; anda larger-diameter coiled portion electrically in series with the smaller-diameter coiled portion, a lumen of the larger-diameter coiled portion having a second coil-lumen-diameter that is larger than the first coil-lumen-diameter, a perpendicular distance from a central longitudinal axis of the smaller-diameter coiled portion to the lumen of the larger-diameter coiled portion being greater than an outer radius of the smaller-diameter coiled portion, when the central longitudinal axis of the smaller-diameter coiled portion is parallel to a central longitudinal axis of the larger-diameter coiled portion;a flexible longitudinal element passing through the larger-diameter coiled portion,wherein the flexible longitudinal element is shaped as a loop, andwherein the flexible longitudinal element loops around the smaller-diameter coiled portion. 21. A method for pacing a heart of a subject, the method comprising: providing a kit comprising: (a) a first implantable pulse generator (IPG); and(b) a first coiled lead connected to the first IPG, the first coiled lead comprising: a smaller-diameter coiled portion, a lumen of which having a first coil-lumen-diameter; anda larger-diameter coiled portion electrically in series with the smaller-diameter coiled portion, a lumen of the larger-diameter coiled portion having a second coil-lumen-diameter that is larger than the first coil-lumen-diameter, a perpendicular distance from a central longitudinal axis of the smaller-diameter coiled portion to the lumen of the larger-diameter coiled portion being greater than an outer radius of the smaller-diameter coiled portion, when the central longitudinal axis of the smaller-diameter coiled portion is parallel to a central longitudinal axis of the larger-diameter coiled portion;(c) a second IPG, which is not electrically or mechanically coupled to the first IPG when contained inside the kit; and(d) a second coiled lead connected to the second IPG, an outer diameter of the second coiled lead being less than the diameter of the lumen of the larger-diameter coiled portion of the first coiled lead;implanting a distal end of the first coiled lead at a first location in a heart of the subject;implanting the first IPG in a blood vessel of the subject;implanting a distal end of the second coiled lead at a second location in the heart of the subject;implanting the second IPG in the blood vessel of the subject; andaligning a portion of the second coiled lead with respect to the larger-diameter coiled portion of the first coiled lead such that a central longitudinal axis of the portion of the second coiled lead passes longitudinally through the larger-diameter coiled portion of the first coiled lead,wherein when the portion of the second coiled lead is aligned with respect to the larger-diameter coiled portion of the first coiled lead such that the central longitudinal axis of the portion of the second coiled lead passes longitudinally through the larger-diameter coiled portion of the first coiled lead: one of the first and the second IPGs is configured to generate a first pacing signal, which passes through its coiled lead and induces a synchronizing signal in the other coiled lead, andthe other one of the first and the second IPGs is configured to receive the synchronizing signal, and generate a second pacing signal in response to the synchronizing signal.
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