IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0267158
(2011-10-06)
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| 등록번호 |
US-9757723
(2017-09-12)
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발명자
/ 주소 |
- Bruno, Colin
- O'Bear, Raymond
- Paris, Cecile
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| 출원인 / 주소 |
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
0 인용 특허 :
37 |
초록
▼
The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are oper
The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.
대표청구항
▼
1. A sample test card, comprising: (a) a card body defining a first surface and a second surface opposite said first surface, a fluid intake port and a plurality of sample wells in which biological reagents have been deposited disposed between said first and second surfaces, said first and second su
1. A sample test card, comprising: (a) a card body defining a first surface and a second surface opposite said first surface, a fluid intake port and a plurality of sample wells in which biological reagents have been deposited disposed between said first and second surfaces, said first and second surfaces sealed with a sealant tape covering said plurality of sample wells;(b) a fluid channel network connecting said fluid intake port to said sample wells, said fluid channel network comprising at least one distribution channel, and a plurality of fill channels connecting said at least one distribution channel to said sample wells, wherein each of said fill channels connects said distribution channel to individual sample wells; and(c) two or more fluid over-flow reservoirs comprising a first fluid over-flow reservoir and a second fluid over-flow reservoir, said two or more over-flow reservoirs being connected to said distribution channel downstream from said sample wells by a fluid over-flow channel, wherein the two or more fluid over-flow reservoirs are connected to the distribution channel in series, such that the first fluid over-flow reservoir is connected directly to the distribution channel via the fluid over-flow channel and the first fluid over-flow reservoir connects the second fluid over-flow reservoir to the distribution channel, and wherein the second fluid over-flow reservoir is configured to receive fluid from the first fluid over-flow reservoir. 2. The test card of claim 1, wherein said test card comprises 96 sample wells arranged as twelve columns of eight sample wells. 3. The test card of claim 1, wherein said test card comprises 112 sample wells arranged as fourteen columns of eight sample wells. 4. The test card of claim 1, further comprising bubble traps in fluid communication with said sample wells, said traps being positioned at least partly above said wells. 5. The test card of claim 1, wherein said one or more over-flow reservoirs further comprise an adsorbent for adsorbing any excess liquid from said fluid channel network. 6. The test card of claim 5, wherein said adsorbent is selected from the group consisting of adsorptive resins, silica gels, hydrogels, molecular sieves, zeolites and other well known adsorbent materials. 7. The test card of claim 1, wherein the fluid channel network further comprises a second distribution channel disposed on said first surface of said test card and operatively connected to said sample wells. 8. The test card of claim 1, further comprising sensor stop holes for aligning the card for optical readings. 9. The test card of claim 8, wherein said sensor stop holes are aligned from about 0.25 mm to about 2 mm ahead of each of said columns of sample wells. 10. The sample test card of claim 1, wherein the fluid over-flow channel has a reduced cross-section compared to the distribution channel. 11. The sample test card of claim 1, wherein the first fluid over-flow reservoir is directly connected to the fluid over-flow channel and a second fluid over-flow channel, wherein the fluid over-flow channel connects the first fluid over-flow reservoir to the distribution channel, and wherein the second fluid-over flow channel connects the first fluid over-flow reservoir to the second fluid over-flow reservoir. 12. The sample test card of claim 1, further comprising a third fluid over-flow reservoir connected in series to the first fluid over-flow reservoir and the second fluid over-flow reservoir, wherein the first fluid over-flow reservoir is connected directly to the distribution channel via the fluid over-flow channel, the second fluid over-flow reservoir connects the third fluid over-flow reservoir to the first fluid over-flow reservoir, and the first fluid over-flow reservoir connects the second fluid over-flow reservoir and the third fluid over-flow reservoir to the distribution channel. 13. A sample test card is provided comprising: (a) a card body defining a first surface and a second surface opposite said first surface, a fluid intake port and a plurality of sample wells in which biological reagents have been deposited disposed between said first and second surfaces, said first and second surfaces sealed with a sealant tape covering said plurality of sample wells;(b) a fluid channel network connecting said fluid intake port to said sample wells, said fluid channel network comprising a single distribution channel disposed on said first surface, said single distribution channel providing a fluid flow path from said fluid intake port to each of said sample wells, and wherein said distribution channel further comprises a plurality of diamond shaped flow reservoirs, each of said diamond shaped flow reservoirs, being directly connected to two or more fill channels and a portion of the distribution channel, wherein each of said diamond shaped flow reservoirs defines a greater width than the distribution channel, wherein each of said fill channels connect said diamond shaped flow reservoir to one of said sample wells, such each diamond shaped flow reservoir connects at least two of said sample wells to the distribution channel, and wherein said diamond shaped flow reservoirs are operable for trapping air to reduce and/or prevent well-to-well contamination; and(c) one or more fluid over-flow reservoirs, said over-flow reservoirs and connected to said distribution channel downstream from said sample wells by a fluid over-flow channel. 14. The test card of claim 13, wherein said test card comprises from about 80 to about 140 total sample wells. 15. The test card of claim 13, wherein said test card comprises 96 sample wells arranged as twelve columns of eight sample wells. 16. The test card of claim 13, wherein said test card comprises 112 sample wells arranged as fourteen columns of eight sample wells. 17. The sample test card of claim 13, wherein the fluid over-flow channel has a reduced cross-section compared to the distribution channel. 18. The sample test card of claim 13, wherein the one or more fluid over-flow reservoirs comprises: two or more fluid over-flow reservoirs comprising a first fluid over-flow reservoir and a second fluid over-flow reservoir, said two or more over-flow reservoirs being connected to said distribution channel downstream from said sample wells by a fluid over-flow channel, wherein the two or more fluid over-flow reservoirs are connected to the distribution channel in series, such that the first fluid over-flow reservoir is connected directly to the distribution channel via the fluid over-flow channel and the first fluid over-flow reservoir connects the second fluid over-flow reservoir to the distribution channel, and wherein the second fluid over-flow reservoir is configured to receive fluid from the first fluid over-flow reservoir. 19. The sample test card of claim 13, wherein the plurality of diamond shaped flow reservoirs comprises a first diamond shaped flow reservoir and a second diamond shaped flow reservoir, and wherein the plurality of diamond shaped flow reservoirs are connected in series, such that the first diamond shaped flow reservoir connects the second diamond shaped flow reservoir to the fluid intake port.
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