초록

The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive methods.

대표청구항 ▼

1. A glycopolymer comprising a plurality of repeating units, wherein each of said repeating units comprises a saccharide moiety (SA), a linking group (L) and a polymer backbone moiety (PB), wherein said repeating units are optionally connected by one or more carbon-carbon double bonds, wherein said

1. A glycopolymer comprising a plurality of repeating units, wherein each of said repeating units comprises a saccharide moiety (SA), a linking group (L) and a polymer backbone moiety (PB), wherein said repeating units are optionally connected by one or more carbon-carbon double bonds, wherein said glycopolymer is of the formula: or a pharmaceutically acceptable salt thereof, wherein: R′ and R″ are each independently selected from the group consisting of unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted cycloalkyl, and unsubstituted or substituted heterocycloalkyl;each of the repeating units is of the formula: R1 and R4 are sulfate, and R2 is sulfite;m is 2; andn is an integer between 30 and 45. 2. The glycopolymer of claim 1, wherein R′ is unsubstituted or substituted cycloalkyl. 3. The glycopolymer of claim 1, wherein R″ is unsubstituted or substituted alkyl. 4. The glycopolymer of claim 3, wherein the polydispersity index of said glycopolymer is less than about 1.5. 5. The glycopolymer of claim 3, wherein the polydispersity index of said glycopolymer is less than about 4. 6. The glycopolymer of claim 5, wherein R′ is unsubstituted cycloalkyl. 7. The glycopolymer of claim 6, wherein R″ is unsubstituted alkyl. 8. The glycopolymer of claim 1, wherein n is 30 or 45. 9. A composition comprising a substantially homogeneous population of a glycopolymer of claim 1. 10. A pharmaceutical composition comprising a glycopolymer of claim 1, and a pharmaceutically acceptable carrier. 11. A pharmaceutical composition comprising a glycopolymer of claim 1, and a second pharmaceutical agent. 12. A kit comprising a glycopolymer of claim 1. 13. A substrate, immobilized thereon a glycopolymer of claim 1. 14. The substrate of claim 13, wherein said substrate comprises a solid support. 15. The substrate of claim 13, wherein said substrate is an array.