Force-controlled applicator for applying a microneedle device to skin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
출원번호
US-0433234
(2013-11-14)
등록번호
US-9789299
(2017-10-17)
국제출원번호
PCT/US2013/070115
(2013-11-14)
국제공개번호
WO2014/078545
(2014-05-22)
발명자
/ 주소
Simmers, Ryan P.
출원인 / 주소
3M INNOVATIVE PROPERTIES COMPANY
대리인 / 주소
3M Innovative Properties Company
인용정보
피인용 횟수 :
0인용 특허 :
24
초록▼
An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first
An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. A method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.
대표청구항▼
1. An applicator for applying a microneedle array to a skin surface, the applicator comprising: a first portion comprising a microneedle array and defining a first major surface from which the microneedle array protrudes, the first major surface configured to be substantially parallel with the skin
1. An applicator for applying a microneedle array to a skin surface, the applicator comprising: a first portion comprising a microneedle array and defining a first major surface from which the microneedle array protrudes, the first major surface configured to be substantially parallel with the skin surface and configured to be positioned toward the skin surface; anda second portion coupled to the first portion via a connector that directly contacts both the first portion and the second portion, the connector configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when an application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first major surface of the first portion that meets or exceeds a threshold application force, the second portion defining a second major surface, the second major surface configured to be positioned toward the skin surface;wherein at least a portion of the microneedle array extends beyond the first major surface and the second major surface when the connector is in the first state,wherein the applicator is configured to be pressed as a whole in a direction substantially perpendicular to the first major surface to press the microneedle array into the skin surface until the threshold application force is reached and the connector is changed to its second state such that after the threshold application force is reached or exceeded continued pressure on the second portion in the direction of the skin will not cause continued pressure on the microneedle array, whereinthe second portion is movable relative to the first portion between(i) a first position in which the connector is in its first state, and the applicator is configured to be applied to the skin surface, and(ii) a second position in which the connector is in its second state, and the microneedles are inserted into the skin; and whereinthe second portion is movable relative to the first portion by the connector being changed from its first state to its second state. 2. The applicator of claim 1, wherein the second portion is spaced a first distance from the first portion when the second portion is in its first position, wherein the second portion is spaced a second distance from the first portion when the second portion is in its second position, and wherein the second distance is less than the first distance. 3. The applicator of claim 1, wherein the applicator is configured to generate: a first force generated by pressing the applicator into the skin surface, anda second force generated by the resistance of the skin surface when the applicator is pressed into the skin surface, andwherein the connector is configured to change to its second state when at least one of the (i) first force, (ii) the second force, and (iii) the sum of the magnitude of the first force and the magnitude of the second force equals or exceeds the threshold application force. 4. The applicator of claim 1, wherein the applicator is free of a stored energy element. 5. The applicator of claim 1, wherein the second portion is configured to be removed from the applicator when the connector is in its second state. 6. The applicator of claim 1, wherein the first portion is configured to remain on the skin surface with the microneedle array for a treatment period. 7. The applicator of claim 1, wherein the applicator is configured to be pressed via the second portion. 8. The applicator of claim 1, wherein the first portion and the second portion are substantially fixed with respect to one another until the connector is changed to its second state. 9. The applicator of claim 8, wherein the applicator is configured to be pressed via the second portion until the connector is changed to its second state and the second portion becomes movable with respect to the first portion. 10. The applicator of claim 1, wherein the second portion has a height that is greater than a height of the first portion and is configured to receive at least a portion of the first portion when the connector is changed to its second state. 11. The applicator of claim 1, wherein the second portion includes a recess, and wherein at least a portion of the first portion is dimensioned to be received in the recess of the second portion. 12. The applicator of claim 11, wherein the connector is positioned to connect a lower portion of an inner wall of the second portion that at least partially defines the recess with an upper portion of the first portion. 13. The applicator of claim 1, wherein the connector extends horizontally between the first portion and the second portion. 14. The applicator of claim 1, wherein the connector extends at least partially horizontally and at least partially vertically between the first portion and the second portion. 15. The applicator of claim 1, wherein the second portion includes an opening formed therein dimensioned to receive the first portion therethrough. 16. The applicator of claim 1, wherein the first portion includes an inner surface that defines a recess, and wherein the second portion includes a projection that is dimensioned to be received in the recess of the first portion when the connector is in its second state. 17. A method of applying a microneedle array to a skin surface, the method comprising: providing the applicator of claim 1;pressing the applicator in a direction substantially perpendicular to the first major surface to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.
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