Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with
Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support member. The filter assemblies may further include a pre-filter and/or a post-filter positioned between the walls of the housing. If provided, the pre- and post-filter may be positioned on opposite walls of the filtration medium, with the post-filter being a mesh positioned between the filtration medium and one of the walls of the housing or within an opening defined by the support member. A seal of the filter assembly may pass through the filtration medium, with the filtration medium being substantially omitted in a section of the seal.
대표청구항▼
1. A biological fluid filter assembly comprising: a flexible housing having first and second walls;a filtration medium at least partially positioned between the first and second walls of the housing;a post-filter mesh at least partially positioned between the filtration medium and the second wall; a
1. A biological fluid filter assembly comprising: a flexible housing having first and second walls;a filtration medium at least partially positioned between the first and second walls of the housing;a post-filter mesh at least partially positioned between the filtration medium and the second wall; anda seal joining the first and second walls of the housing, whereinthe first wall includes an inlet port, the second wall includes an outlet port, and the first and second walls are made from a plastic material;a pre-filter is at least partially positioned between the inlet port and the filtration medium;the post-filter mesh is integrally formed with a frame and is made from the plastic material; andan inner seal is formed by integrating a section of the filtration medium at or adjacent to a perimeter of the filtration medium, a section of the pre-filter at or adjacent to a perimeter of the pre-filter, a section of the frame of the post-filter mesh, and a section of the first and second walls at or adjacent to a perimeter of the first and second walls and over the entire perimeter of the first and second walls, wherein the inner seal comprises a central section consisting of a layer consisting only of the plastic material of the first wall and having a thickness in the range of approximately 90-250 micrometers,an intermingled layer in which the plastic material of at least the first wall is intermingled with the pre-filter and having a thickness in the range of approximately 170-300 micrometers, andan aggregate in which the plastic material of at least the second wall and the frame are intermingled and having a thickness in the range of approximately 0.84-1.5 millimeters. 2. The biological fluid filter assembly of claim 1, further comprising a pair of peripheral sections, with the peripheral sections positioned at opposite sides of the central section and each comprising a layer consisting only of the plastic material of the first wall,an intermingled layer in which the plastic material of at least the first wall is intermingled with the pre-filter,an intermingled interface in which molten filtration medium is intermingled with the pre-filter,a layer consisting only of molten filtration medium,a second intermingled interface in which molten filtration medium is intermingled with the frame,a second intermingled layer in which the plastic material of at least the second wall and the frame are intermingled, anda layer consisting only of the plastic material of the second wall, wherein the intermingled interface and the second intermingled interface each have a thickness of less than 150 micrometers. 3. The biological fluid filter assembly of claim 2, wherein the filtration medium transitions from a molten state at an end of each peripheral section adjacent to the central section of the seal to a non-molten state at an opposite end of each peripheral section. 4. The biological fluid filter assembly of claim 1, wherein the plastic material is polyvinyl chloride. 5. A biological fluid filter assembly comprising: a flexible housing having first and second walls;a filtration medium at least partially positioned between the first and second walls of the housing;a post-filter mesh at least partially positioned between the filtration medium and the second wall;a seal joining the first and second walls of the housing; andan inner seal joining the first and second walls of the housing, the inner seal passing through the filtration medium to define a perimeter within the biological fluid filter assembly, with substantially no filtration medium present in a central section of the inner seal along at least a majority of the extent of the perimeter defined by the inner seal. 6. The biological fluid filter assembly of claim 5, wherein the first and second walls are generally transparent,the filtration medium is generally opaque, andthe central section of the inner seal is generally transparent along at least a majority of the extent of the perimeter defined by the inner seal. 7. The biological fluid filter assembly of claim 6, wherein the filtration medium is present in generally opaque peripheral sections of the inner seal. 8. The biological fluid filter assembly of claim 5, further comprising a pre-filter at least partially positioned between the filtration medium and the first wall of the housing, wherein the inner seal joins the first and second walls of the housing and the pre-filter. 9. The biological fluid filter assembly of claim 5, further comprising a support member at least partially positioned between the filtration medium and the second wall of the housing, wherein the inner seal joins the first and second walls of the housing and the support member. 10. The biological fluid filter assembly of claim 9, wherein the support member comprises a frame integrally formed with the post-filter mesh.
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