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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0875539 (2015-10-05) |
등록번호 | US-9801574 (2017-10-31) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 357 |
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observab
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
1. An implantable device for measuring an analyte in a biological fluid, comprising: an implantable sensor comprising an electrochemically reactive surface; anda membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a matrix comprising a
1. An implantable device for measuring an analyte in a biological fluid, comprising: an implantable sensor comprising an electrochemically reactive surface; anda membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a matrix comprising a first polymer and a second polymer dispersed throughout the matrix, wherein the first polymer is polyurethane urea, wherein the second polymer comprises at least one hydrophilic component, wherein the hydrophilic component of the second polymer forms in the membrane hydrophilic segments along which the analyte diffuses. 2. The implantable device of claim 1, wherein the second polymer comprises polyethylene oxide. 3. The implantable device of claim 2, wherein polyethylene oxide comprises about 20% by weight of the second polymer. 4. The implantable device of claim 2, wherein the polyethylene oxide has an average molecular weight from 200 to 3,000 Daltons. 5. The implantable device of claim 1, wherein the hydrophilic segments comprise a network of microdomains. 6. The implantable device of claim 5, wherein the microdomains are not photomicroscopically observable when hydrated at 400× magnification or less. 7. The implantable device of claim 5, wherein the network of are substantially dispersed throughout the matrix. 8. The implantable device of claim 1, wherein the membrane has a thickness from 5 to 100 microns. 9. The implantable device of claim 1, wherein the membrane is configured to yield calibration factors that are stable over the life of the sensor. 10. The implantable device of claim 1, wherein the analyte is glucose.
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