This present invention provides a delivery device that could be used to delivery discreet small volume of expensive biotechnology treatments to specific areas of the oral cavity, or other tissues. The present invention also provides a method of using the device disclosed herein to deliver biotechnol
This present invention provides a delivery device that could be used to delivery discreet small volume of expensive biotechnology treatments to specific areas of the oral cavity, or other tissues. The present invention also provides a method of using the device disclosed herein to deliver biotechnology treatments and/or therapeutic agents to specific areas of the oral cavity, or other tissues. In one embodiment, the treatments and/or therapeutic agents are delivered to the interproximal area between and around the teeth.
대표청구항▼
1. A device for delivering therapeutic agents to a subject, comprising a) a peristaltic pump driven by a motor, wherein the peristaltic pump comprises a peristaltic pump head and a pneumatic piston;b) a liquid reservoir which is connected to a mixing chamber via pump tubing, wherein the mixing chamb
1. A device for delivering therapeutic agents to a subject, comprising a) a peristaltic pump driven by a motor, wherein the peristaltic pump comprises a peristaltic pump head and a pneumatic piston;b) a liquid reservoir which is connected to a mixing chamber via pump tubing, wherein the mixing chamber is located above said pneumatic piston and the pump tubing passes through the peristaltic pump head;c) a spring which is connected to a shaft of the pneumatic piston; andd) an outlet channel for dispersing aerosolized therapeutic agents out of the device, wherein the peristaltic pump delivers liquid from the liquid reservoir to the mixing chamber via the pump tubing, said liquid is aerosolized in the mixing chamber during a power stroke of the pneumatic piston and delivered to the subject, the peristaltic pump is connected to the motor via a reduction gear and a conversion gear, wherein said reduction gear is articulated with said conversion gear and the conversion gear comprises a smaller diameter gear-set close to an axle of the conversion gear, wherein said smaller diameter gear-set articulates with a gear-tooth section on the shaft of the pneumatic piston. 2. A method of using the device of claim 1 to deliver therapeutic agents to a tissue of a subject, comprising the steps of: a) loading said therapeutic agents into the liquid reservoir of said device;b) aerosolizing said therapeutic agents in the mixing chamber; andc) delivering the aerosolized therapeutic agents to the tissue. 3. The method of claim 2, wherein the tissue is an oral cavity. 4. The method of claim 2, wherein the tissue is gingiva. 5. The method of claim 2, wherein the tissue is an interproximal area between and around teeth of an oral cavity. 6. A device for delivering therapeutic agents to a subject, comprising a) a peristaltic pump driven by a motor, wherein the peristaltic pump comprises a peristaltic pump head and a pneumatic piston;b) a liquid reservoir which is connected to a mixing chamber via pump tubing, wherein the mixing chamber is located above said pneumatic piston and the pump tubing passes through the peristaltic pump head;c) a spring which is connected to a shaft of the pneumatic piston; andd) an outlet channel for dispersing aerosolized therapeutic agents out of the device, wherein the peristaltic pump delivers liquid from the liquid reservoir to the mixing chamber via the pump tubing, said liquid is aerosolized in the mixing chamber during a power stroke of the pneumatic piston and delivered to the subject, the pneumatic piston is drawn back against the spring and then released, thereby generating a power stroke by the reflection of the compressed spring, and when the pneumatic piston is being drawn back, a valve located in the mixing chamber is closed and a valve located outside the mixing chamber is opened to allow air to enter into a chamber above the pneumatic piston. 7. A method of using the device of claim 6 to deliver therapeutic agents to a tissue of a subject, comprising the steps of: a) loading said therapeutic agents into the liquid reservoir of said device;b) aerosolizing said therapeutic agents in the mixing chamber; andc) delivering the aerosolized therapeutic agents to the tissue. 8. The method of claim 7, wherein the tissue is an oral cavity. 9. The method of claim 7, wherein the tissue is gingiva. 10. The method of claim 7, wherein the tissue is an interproximal area between and around teeth of an oral cavity. 11. A device for delivering therapeutic agents to a subject, comprising a) a peristaltic pump driven by a motor, wherein the peristaltic pump comprises a peristaltic pump head and a pneumatic piston;b) a liquid reservoir which is connected to a mixing chamber via pump tubing, wherein the mixing chamber is located above said pneumatic piston and the pump tubing passes through the peristaltic pump head;c) a spring which is connected to a shaft of the pneumatic piston; andd) an outlet channel for dispersing aerosolized therapeutic agents out of the device, wherein the peristaltic pump delivers liquid from the liquid reservoir to the mixing chamber via the pump tubing, said liquid is aerosolized in the mixing chamber during a power stroke of the pneumatic piston and delivered to the subject, the pneumatic piston is drawn back against the spring and then released, thereby generating a power stroke by the reflection of the compressed spring, and when the pneumatic piston is being released, a valve located in the mixing chamber is opened and a valve located outside the mixing chamber is closed to allow air to enter into the mixing chamber. 12. A method of using the device of claim 11 to deliver therapeutic agents to a tissue of a subject, comprising the steps of: a) loading said therapeutic agents into the liquid reservoir of said device;b) aerosolizing said therapeutic agents in the mixing chamber; andc) delivering the aerosolized therapeutic agents to the tissue. 13. The method of claim 12, wherein the tissue is an oral cavity. 14. The method of claim 12, wherein the tissue is gingiva. 15. The method of claim 12, wherein the tissue is an interproximal area between and around teeth of an oral cavity.
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이 특허에 인용된 특허 (5)
Jass Herman E. (Princeton NJ) Kohlhepp Frederick F. (Princeton Junction NJ), Aerosol package.
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