Super-soft foam materials, optionally for use as medical dressings, are provided. The pads are made of a foam prepared from NCO-terminated prepolymers in combination with an aqueous phase including fatty alcohols and alkyl polysaccharides. The foam may optionally contain at least one medicinal agent
Super-soft foam materials, optionally for use as medical dressings, are provided. The pads are made of a foam prepared from NCO-terminated prepolymers in combination with an aqueous phase including fatty alcohols and alkyl polysaccharides. The foam may optionally contain at least one medicinal agent.
대표청구항▼
1. A medical product comprising: a dried, porous foam produced from a composition for a foam comprising: at least one NCO-terminated hydrophilic urethane prepolymer comprising a reaction product of at least one isocyanate selected from the group consisting of aromatic isocyanates, aliphatic isocyana
1. A medical product comprising: a dried, porous foam produced from a composition for a foam comprising: at least one NCO-terminated hydrophilic urethane prepolymer comprising a reaction product of at least one isocyanate selected from the group consisting of aromatic isocyanates, aliphatic isocyanates, and combinations thereof, in combination with a polyether polyol comprising a reaction product of an ethylene oxide and a compound containing at least two active hydrogen atoms selected from the group consisting of polyhydric alcohols, polyhydric phenols, amines, polycarboxylic acids, and phosphorous acids;an aqueous phase comprising deionized water, at least one fatty alcohol, and at least one alkyl polysaccharide; andan antimicrobial agent selected from the group consisting of polyhexamethylene biguanide (PHMB), polyethylene hexamethylene biguanide, and combinations thereof, wherein the antimicrobial agent is present in the composition in an amount up to about 20,000 ppm. 2. The medical product of claim 1, wherein the polyether polyol has an oxyethylene content from about 50% to about 90% by weight and the at least one isocyanate is selected from the group consisting of p-phenylene diisocyanate, 4,4′-diphenylmethane diisocyanate and position isomers thereof, 2,4-toluene diisocyanate and position isomers thereof, 3,4-dichlorophenyl diisocyanate, dicyclohexylmethane-4,4′-diisocyanate, 1,6-hexamethylene diisocyanate and position isomers thereof, isophorone diisocyanate, and combinations thereof. 3. The medical product of claim 1, wherein the at least one fatty alcohol is selected from the group consisting of caproic alcohol, caprylic alcohol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, hexyl decanol, palmitoleyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, linolyl alcohol, linolenyl alcohol, elaeostearyl alcohol, arachyl alcohol, gadoleyl alcohol, behenyl alcohol, octyl dodecanol, erucyl alcohol, brassidyl alcohol, coconut oil, and combinations thereof. 4. The medical product of claim 3, wherein the aqueous phase further comprises an ether comprising the reaction product of ethylene oxide with an alcohol selected from the group consisting of caproic alcohol, caprylic alcohol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, hexyl decanol, palmitoleyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, linolyl alcohol, linolenyl alcohol, elaeostearyl alcohol, arachyl alcohol, gadoleyl alcohol, octyl dodecanol, behenyl alcohol, erucyl alcohol, brassidyl alcohol, and combinations thereof. 5. The medical product of claim 1, wherein the at least one alkyl polysaccharide comprises a hydrophobic group having from about 8 to about 20 carbon atoms and a polysaccharide hydrophilic group having from about 1.5 to about 10 saccharide units. 6. The medical product of claim 1, wherein the at least one alkyl polysaccharide is selected from the group consisting of glucosides, galactosides, lactosides, fructosides, fructosyls, lactosyls, glucosyls, galactosyls, and mixtures thereof. 7. The medical product of claim 1, wherein the aqueous phase comprises deionized water, cetearyl alcohol, polyoxyethylene ether derived from cetyl alcohol and stearyl alcohol, and an alkyl polyglucoside of the formula: RO(CnH2nO)r(Z)x; wherein Z is derived from glucose, R is a hydrophobic group selected from the group consisting of alkyl, alkylphenyl, hydroxyalkylphenyl, and mixtures thereof having from about 10 to about 18 carbon atoms, n is from about 2 to about 3, r is from about 0 to about 10, and x is from about 1.5 to about 8. 8. The medical product of claim 1, wherein the antimicrobial agent comprises PHMB, wherein the PHMB is present in the composition in an amount between about 5,000 ppm and about 20,000 ppm. 9. The medical product of claim 8, wherein the antimicrobial agent is present in an amount sufficient to provide at least a 2 log reduction in the quantity of one or more common wound pathogens over an exposure period of at least seven days, and wherein the one or more wound pathogens comprise one or more of Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus auereus, Escherichia coli, Enterococcus faecalis, and Candida albicans. 10. The medical product of claim 8, wherein the antimicrobial agent is present in an amount sufficient to provide at least a 2 log reduction in the quantity of one or more common wound pathogens after an exposure period of no more than about 10 minutes. 11. The medical product of claim 1, constructed to provide a zone of inhibition upon exposure to one or more wound pathogens that increases after a period of exposure of at least 3 days. 12. The medical product of claim 1, wherein the medical product has an Identation Force Deflection at 25% indentation (IFD 25%) from about 1 pound to about 2 pounds, an Indentation Force Deflection at 65% indentation (IFD 65%) from about 3.5 pounds to about 9 pounds, a support factor from about 3.5 to about 4.5, and a conformability value of from about 0.01 N/cm3 to about 0.1 N/cm3. 13. The medical product of claim 1, wherein the medical product has a fluid capacity under compression equivalent to 18 mm Hg of about 4 to about 8 cc/in2. 14. The medical product of claim 1, wherein the medical product has a fluid capacity under compression equivalent to 40 mm Hg of about 3 to about 7 cc/in2. 15. The medical product of claim 1, further comprising a backing layer selected from the group consisting of polyurethanes, acetate fibers, acrylic fibers, cellulose ester fibers, modacrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foam, and combinations thereof. 16. The medical product of claim 1, further comprising a backing layer selected from the group consisting of polyurethanes, polyester fibers, rayon fibers, and combinations thereof, optionally in combination with an adhesive selected from the group consisting of acrylic adhesives, hydrocolloid adhesives, hydrogel adhesives, polyurethane adhesives, and silicone adhesives. 17. The medical product of claim 1, wherein the at least one fatty alcohol is selected from the group consisting of caproic alcohol, caprylic alcohol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, hexyl decanol, palmitoleyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, linolyl alcohol, linolenyl alcohol, elaeostearyl alcohol, arachyl alcohol, gadoleyl alcohol, behenyl alcohol, octyl dodecanol, erucyl alcohol, brassidyl alcohol, coconut oil, and combinations thereof, and wherein the at least one alkyl polysaccharide is of the formula: RO(CnH2nO)r(Z)x wherein Z is derived from glucose, R is a hydrophobic group selected from the group consisting of alkyl, alkylphenyl, hydroxyalkylphenyl, and mixtures thereof having from about 10 to about 18 carbon atoms, n is from about 2 to about 3, r is from about 0 to about 10, and x is from about 1.5 to about 8. 18. A wound dressing comprising: a dried, porous foam formed by a composition comprising: at least one NCO-terminated hydrophilic urethane prepolymer comprising a reaction product of at least one isocyanate selected from the group consisting of aromatic isocyanates, aliphatic isocyanates, and combinations thereof, in combination with a polyether polyol comprising a reaction product of an ethylene oxide and a compound containing at least two active hydrogen atoms selected from the group consisting of polyhydric alcohols, polyhydric phenols, amines, polycarboxylic acids, and phosphorous acids;an aqueous phase comprising deionized water, cetearyl alcohol, polyoxyethylene ether derived from cetyl alcohol and stearyl alcohol, and an alkyl polyglucoside of the formula: RO(CnH2nO)r(Z)x; wherein Z is derived from glucose, R is a hydrophobic group selected from the group consisting of alkyl, alkylphenyl, hydroxyalkylphenyl, and mixtures thereof having from about 10 to about 18 carbon atoms, n is from about 2 to about 3, r is from about 0 to about 10, and x is from about 1.5 to about 8; andfrom about 5,000 ppm to about 20,000 ppm of an antimicrobial agent comprising polyhexamethylene biguanide. 19. The medical product of claim 18, wherein the foam has an Indentation Force Deflection at 25% indentation (IFD 25%) between about 1 pound to about 2 pounds, and an Indentation Force Deflection at 65% indentation (IFD 65%) between about 3.5 pounds to about 9 pounds.
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