IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0099728
(2008-04-08)
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등록번호 |
US-9814230
(2017-11-14)
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발명자
/ 주소 |
- Fishman, Robert
- Havener, Robert
- Fattah, Ihab Abdel
- Abdelazim, Anas
- Newell, Scott
- Bishop, Tom
- Khayal, Tamer
- Kyi, Stanley
- Taylor, Ron
- Harriott, Doug
- De Remer, Matthew
- Murray, Paul
- Sullivan, John
- Anderson, Mark
- Bringham, Richard
- Van Driel, Michael
- Hassanein, Waleed
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출원인 / 주소 |
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대리인 / 주소 |
Wilmer Cutler Pickering Hale and Dorr LLP
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인용정보 |
피인용 횟수 :
0 인용 특허 :
127 |
초록
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Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
대표청구항
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1. A lung care system comprising: a ventilation gas circuit;a portable multiple use module including: a portable chassis;a lung console module comprising: a pneumatic control system for controlling at least one valve in the ventilation gas circuit; anda pneumatic connector comprising a first set of
1. A lung care system comprising: a ventilation gas circuit;a portable multiple use module including: a portable chassis;a lung console module comprising: a pneumatic control system for controlling at least one valve in the ventilation gas circuit; anda pneumatic connector comprising a first set of gas lumens including at least a lumen connected to a gas exchanger, a lumen connected to the ventilation gas circuit, and a pneumatic control connection;a single use disposable module, the ventilation gas circuit configured to connect to a lung in the single use disposable module;the single use disposable module including: an interface adapted to couple the single use disposable module with the multiple use module for electro-mechanical interoperation with the multiple use module;a lung perfusion module connector comprising a second set of gas lumens including at least a lumen connected to a gas exchanger, a lumen connected to the ventilation gas circuit, and a pneumatic control connection;a lung chamber assembly having a first interface for allowing a flow of a perfusion fluid into the lung, a second interface connected to the ventilation gas circuit for allowing ventilation of the lung with a ventilation gas, anda third interface for allowing a flow of the perfusion fluid away from the lung,the lung chamber assembly including a dual drain system for carrying the flow of the perfusion fluid away from the lung, the dual drain system comprising a measurement drain for directing a part of the perfusion fluid flow to a sensor of a perfusion fluid gas content and a main drain for receiving a remaining part of perfusion fluid flow; and,wherein the pneumatic connector provides a rapid hook-up connection to the matching lung perfusion module connector to provide at least gas connection and pneumatic control connection between the portable multiple use module and the single use disposable module. 2. The system of claim 1, wherein the dual drain further comprises a vessel for collecting the flow of perfusion fluid away from the lung into a pool which feeds into the measurement drain, a drainage capacity of the measurement drain being less than a flow rate of the perfusion fluid away from the lung, wherein excess perfusion fluid overflowing the vessel flows to the main drain. 3. The system of claim 1, wherein the disposable module further comprises a pump adapted to circulate the perfusion fluid through the lung. 4. The system of claim 1, further comprising a ventilation system connected to the second interface for ventilating the lung with a gas having a predetermined composition. 5. The system of claim 4, wherein the predetermined composition includes about 12% oxygen. 6. The system of claim 4, wherein the predetermined composition is about 12% oxygen, about 5.5% carbon dioxide, and about 82.5% nitrogen. 7. The system of claim 1, further including a conduit that provides fluid communication between the main drain and a reservoir for the perfusion fluid. 8. The system of claim 1 wherein the lung console module further provides at least one of electrical, pneumatic, and mechanical control of the disposable module. 9. The system of claim 8, wherein the lung console module includes a ventilation controller for controlling the ventilation of the lung. 10. The system of claim 9, wherein the ventilation controller includes a mechanical actuator for actuating a bellows for causing a flow of ventilation gas into the lung. 11. The system of claim 10, wherein the at least one valve is disposed in the ventilation gas circuit between the lung and the bellows, an off position of the valve closing a gas connection between the lung and the bellows. 12. The system of claim 10, wherein the at least one valve includes a relief valve for venting ventilation gas from the ventilation gas circuit. 13. The system of claim 10, wherein the at least one valve includes a trickle valve for introducing a ventilation gas to the ventilation gas circuit. 14. The system of claim 9, wherein the ventilation controller is capable of selecting one of a plurality of gases for ventilating the lung. 15. The system of claim 14, wherein the plurality of gases includes an oxygenation gas, a deoxygenation gas, and a maintenance gas. 16. The system of claim 15, wherein the oxygenation gas is selected from a set consisting of air and a gas containing between 25% and 100% oxygen. 17. The system of claim 15, wherein the deoxygenation gas comprises carbon dioxide and nitrogen. 18. The system of claim 15, wherein the deoxygenation gas is composed of about 6% carbon dioxide and about 94% nitrogen. 19. The system of claim 15, wherein the maintenance gas comprises oxygen, carbon dioxide, and nitrogen. 20. The system of claim 15, wherein the maintenance gas is composed of about 12% oxygen, about 5.5% carbon dioxide, and about 82.5% nitrogen. 21. The system of claim 15, wherein the maintenance gas is supplied from a tank housed within the multiple use module. 22. The system of claim 8, wherein the portable multiple use module comprises a perfusion fluid controller for controlling a perfusion fluid gas component. 23. The system of claim 22, wherein the perfusion fluid controller includes a pneumatic valve controller for controlling a flow of gas to the gas exchanger in the disposable module, wherein the gas exchanger is configured to exchange gases between the flow of gas to the gas exchanger and the perfusion fluid. 24. The system of claim 23, wherein the flow of gas to the gas exchanger comprises a deoxygenation gas for removing oxygen from the perfusion fluid. 25. The system of claim 24, wherein the deoxygenation gas comprises carbon dioxide and nitrogen. 26. The system of claim 24, wherein the deoxygenation gas is composed of about 6% carbon dioxide and about 94% nitrogen. 27. The system of claim 1, wherein the multiple use module includes a monitor for displaying a status of the lung care system and a user interface for controlling an operation of the lung care system. 28. The system of claim 27, wherein the displayed status includes at least one of an oxygen content of the perfusion fluid entering the lung and an oxygen content of the perfusion fluid exiting the lung. 29. The system of claim 27, wherein the monitor displays a real time trace of a ventilation gas pressure where the gas enters the lung, a real time trace of pulmonary arterial pressure of the lung as measured by a pressure sensor located where the perfusion fluid enters the pulmonary artery, and a time-averaged graph of pulmonary arterial pressure. 30. The system of claim 1, wherein the multiple use module includes a monitor for displaying a status of the lung care system during assessment of the lung, and a user interface for controlling an operation of the lung care system, wherein the monitor displays a real time trace of an oxygen content of the perfusion fluid entering the lung and a real time trace of an oxygen content of the perfusion fluid leaving the lung. 31. A lung care system comprising: a ventilation gas circuit;a portable multiple use module including a portable chassis and a lung console comprising a pneumatic control system for controlling at least one valve in the ventilation gas circuit anda pneumatic connector comprising a first set of gas lumens including at least a lumen connected to a gas exchanger, a lumen connected to the ventilation gas circuit, and a pneumatic control connection;a single use disposable module, the ventilation gas circuit configured to connect to a lung in the single use disposable module;the single use disposable module including: a lung perfusion module connector comprising a second set of gas lumens including at least a lumen connected to a gas exchanger, a lumen connected to the ventilation gas circuit, and a pneumatic control connectionan interface adapted to couple the single use disposable module with the multiple use module for electro-mechanical interoperation with the multiple use module; anda lung chamber assembly having a first interface for allowing a flow of a perfusion fluid into the lung, a second interface connected to the ventilation gas circuit for allowing ventilation of the lung with a ventilation gas, and a third interface for allowing a flow of the perfusion fluid away from the lung, whereinthe lung console provides at least one of electrical, pneumatic, and mechanical control of the perfusion fluid and the ventilation gas in the disposable module and,wherein the pneumatic connector provides a rapid hook-up connection to the matching lung perfusion module connector to provide at least gas connection and pneumatic control connection between the portable multiple use module and the single use disposable module. 32. The system of claim 31, wherein the lung chamber assembly includes a dual drain system for carrying the flow of the perfusion fluid away from the lung, the dual drain system comprising a measurement drain for directing a part of the perfusion fluid flow to a sensor of a perfusion fluid gas content and a main drain for receiving a remaining part of perfusion fluid flow. 33. The system of claim 32, wherein the dual drain further comprises a vessel for collecting the flow of perfusion fluid away from the lung into a pool which feeds the measurement drain, a drainage capacity of the measurement drain being less than a flow rate of the perfusion fluid away from the lung, wherein excess perfusion fluid overflowing the vessel flows to the main drain. 34. The system of claim 31, wherein the disposable module further comprises a pump adapted to circulate the perfusion fluid through the lung. 35. The system of claim 31, wherein the disposable module further comprises a ventilation system connected to the second interface for ventilating the lung with a gas having a predetermined composition. 36. The system of claim 35, wherein the predetermined composition includes about 12% oxygen. 37. The system of claim 35, wherein the predetermined composition is about 12% oxygen, about 5.5% carbon dioxide, and about 82.5% nitrogen. 38. The system of claim 32, wherein the main drain directs the remaining part of the perfusion fluid to a reservoir. 39. The system of claim 31, wherein the lung console includes a ventilation controller for controlling the ventilation of the lung. 40. The system of claim 39, wherein the ventilation controller includes a mechanical actuator for actuating a bellows for causing a flow of ventilation gas into the lung. 41. The system of claim 40, wherein the at least one valve is disposed in the ventilation gas circuit between the lung and the bellows, an off position of the valve closing a fluid connection between the lung and the bellows. 42. The system of claim 40, wherein the at least one valve includes a relief valve for venting ventilation gas from the ventilation gas circuit. 43. The system of claim 40, wherein the at least one valve includes a trickle valve for delivering a ventilation gas to the ventilation gas circuit. 44. The system of claim 39, wherein the ventilation controller is configured to select one of a plurality of gases for ventilating the lung. 45. The system of claim 44, wherein the plurality of gases includes an oxygenation gas, a deoxygenation gas, and a maintenance gas. 46. The system of claim 45, wherein the oxygenation gas is selected from a set consisting of air and a gas containing between 25% and 100% oxygen. 47. The system of claim 45, wherein the deoxygenation gas comprises carbon dioxide and nitrogen. 48. The system of claim 45, wherein the deoxygenation gas is composed of about 6% carbon dioxide and about 94% nitrogen. 49. The system of claim 45, wherein the maintenance gas comprises oxygen, carbon dioxide, and nitrogen. 50. The system of claim 45, wherein the maintenance gas is composed of about 12% oxygen, about 5.5% carbon dioxide, and about 82.5% nitrogen. 51. The system of claim 45, wherein the maintenance gas is supplied from a tank housed within the multiple use module. 52. The system of claim 31, wherein the lung console includes a perfusion fluid controller for controlling a perfusion fluid gas component. 53. The system of claim 52, wherein the perfusion fluid controller includes a pneumatic valve controller for controlling a flow of gas to a gas exchanger in the disposable module, wherein the gas exchanger is configured to exchange gases between the flow of gas to the gas exchanger and the perfusion fluid. 54. The system of claim 53, wherein the flow of gas to the gas exchanger comprises a deoxygenation gas for removing oxygen from the perfusion fluid. 55. The system of claim 54, wherein the deoxygenation gas comprises carbon dioxide and nitrogen. 56. The system of claim 54, wherein the deoxygenation gas is composed of about 6% carbon dioxide and about 94% nitrogen. 57. The system of claim 31, wherein the multiple use module includes a monitor for displaying a status of the lung care system and a user interface for controlling an operation of the lung care system. 58. The system of claim 57, wherein the displayed status includes at least one of an oxygen content of the perfusion fluid entering the lung and an oxygen content of the perfusion fluid exiting the lung. 59. The system of claim 57, wherein the monitor displays a real time trace of a ventilation gas pressure where the gas enters the lung, a real time trace of pulmonary arterial pressure of the lung as measured by a pressure sensor located where the perfusion fluid enters the pulmonary artery, and a time-averaged graph of pulmonary arterial pressure. 60. The system of claim 31, wherein the multiple use module includes a monitor for displaying a status of the lung care system during assessment of the lung, and a user interface for controlling an operation of the lung care system, wherein the monitor displays a real time trace of an oxygen content of the perfusion fluid entering the lung and a real time trace of an oxygen content of the perfusion fluid leaving the lung.
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