A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent
A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
대표청구항▼
1. A method for making a drug-coated angioplasty catheter, comprising: applying a solution of a lipophilic drug directly to a surface of a balloon wall of a balloon of an angioplasty catheter, and drying the solution to form a coating of the lipophilic drug directly on the balloon wall to provide an
1. A method for making a drug-coated angioplasty catheter, comprising: applying a solution of a lipophilic drug directly to a surface of a balloon wall of a balloon of an angioplasty catheter, and drying the solution to form a coating of the lipophilic drug directly on the balloon wall to provide an outermost surface over the balloon, wherein said solution comprises a solvent, said lipophilic drug, and an iodine-containing radiopaque agent, and said lipophilic drug is selected from prostacyclin and prostacyclin analogues, rapamycine, colchicine, and paclitaxel. 2. The method of claim 1, wherein the lipophilic drug is paclitaxel. 3. The method of claim 2, wherein the solution consists of said solvent, paclitaxel, and said radiopaque agent. 4. The method of claim 1, wherein the solution consists of said solvent, said lipophilic drug, and said radiopaque agent. 5. The method of claim 1, also comprising processing said angioplasty catheter to be suitable for insertion into a patient with said coating providing said outermost surface. 6. The method of claim 1, wherein said solvent is ethanol. 7. A method of claim 1, wherein said solution consists of ethanol, paclitaxel, and an iodine-containing radiopaque agent, and said applying is by immersing said balloon surface into said solution. 8. The method of claim 1, wherein the lipophilic drug is rapamycine. 9. A method for making a drug-coated angioplasty device, comprising: applying a solution of a lipophilic drug directly to a surface of a balloon of an angioplasty device, said solution comprising a solvent, said lipophilic drug, and an iodine-containing radiopaque agent, and drying the solution to form a coating of the lipophilic drug directly on the surface of said balloon to provide an outermost surface over said balloon, wherein said lipophilic drug is selected from prostacyclin and prostacyclin analogues, rapamycine, colchicine, and paclitaxel. 10. The method of claim 9, wherein the lipophilic drug is paclitaxel. 11. The method of claim 10, wherein the solution consists of said solvent, paclitaxel, and said radiopaque agent. 12. The method of claim 9, wherein the solution consists of said solvent, said lipophilic drug, and said radiopaque agent. 13. The method of claim 9, also comprising rendering said angioplasty device suitable for insertion into a patient with said coating providing said outermost surface. 14. The method of claim 9, wherein said surface is a balloon wall surface of the angioplasty device. 15. The method of claim 9, wherein the lipophilic drug is rapamycine. 16. A method for making an angioplasty device useful for applying a lipophilic drug to a wall of a vascular vessel of a patient, the angioplasty device comprising a balloon having an outermost surface for contact with the wall of the vascular vessel, the method comprising: processing an angioplasty device so as to be suitable for insertion into a patient to perform an angioplasty, wherein the processed angioplasty device comprises a balloon having an outermost coating comprising a lipophilic drug, the outermost coating positioned on a portion of the balloon that contacts the wall of the vascular vessel upon conduct of an angioplasty procedure with the angioplasty device; wherein said processing includes applying an amount of a solution comprising a solvent, said lipophilic drug, and an iodine-containing radiopaque agent directly to the balloon to form said outermost coating, and wherein said lipophilic drug is selected from prostacyclin and prostacyclin analogues, rapamycine, colchicine, and paclitaxel. 17. The method of claim 16, wherein said lipophilic drug is paclitaxel. 18. The method of claim 16, wherein the solution consists of said solvent, paclitaxel, and said radiopaque agent. 19. The method of claim 16, wherein the solution consists of said solvent, said lipophilic drug, and said radiopaque agent. 20. The method of claim 16, wherein the lipophilic drug is rapamycine. 21. A method for making a drug-coated angioplasty catheter, comprising: applying a solution of a lipophilic drug directly to a surface of a balloon wall of a balloon of the angioplasty catheter and drying the solution to form a coating comprising the lipophilic drug directly on the balloon wall to provide an outermost surface over the balloon, wherein said solution comprises a solvent, said lipophilic drug, and an iodine-containing radiopaque agent, and said lipophilic drug is selected from prostacyclin and prostacyclin analogues, rapamycine, colchicine, and paclitaxel. 22. A method for making a drug-coated angioplasty device, comprising: applying a solution of a lipophilic drug directly to a surface of a polymeric balloon wall of a balloon of an angioplasty device and drying the solution to form a coating of the lipophilic drug directly on the polymeric balloon wall to provide an outermost surface over the balloon, wherein said solution comprises a solvent, said lipophilic drug, and an iodine-containing radiopaque agent, and said lipophilic drug is selected from prostacyclin and prostacyclin analogues, rapamycine, colchicine, and paclitaxel.
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