Neisseria meningitidis compositions and methods thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/00
C07K-014/22
A61K-039/095
A61K-039/12
A61K-039/39
C12N-007/00
A61K-039/13
A61K-039/295
출원번호
US-0470922
(2014-08-27)
등록번호
US-9822150
(2017-11-21)
발명자
/ 주소
Anderson, Annaliesa Sybil
Arumugham, Rasappa Gounder
Farley, John Erwin
Fletcher, Leah Diane
Harris, Shannon
Jansen, Kathrin Ute
Jones, Thomas Richard
Khandke, Lakshmi
Loun, Bounthon
Perez, John Lance
Zlotnick, Gary Warren
출원인 / 주소
Pfizer Inc.
대리인 / 주소
Chau, Anna C.
인용정보
피인용 횟수 :
2인용 특허 :
70
초록▼
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the a
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
대표청구항▼
1. A method of inducing a bactericidal immune response against a Neisseria meningitidis serogroup B subfamily A strain and against a Neisseria meningitidis serogroup B subfamily B strain in a human, comprising administering to the human an effective amount of a composition, said composition comprisi
1. A method of inducing a bactericidal immune response against a Neisseria meningitidis serogroup B subfamily A strain and against a Neisseria meningitidis serogroup B subfamily B strain in a human, comprising administering to the human an effective amount of a composition, said composition comprising a) a first lipidated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1, andb) a second lipidated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 2. 2. The method according to claim 1, wherein the composition further comprises polysorbate-80, aluminum, histidine, and sodium chloride. 3. The method according to claim 1, wherein the immune response against the Neisseria meningitidis serogroup B subfamily A strain is greater than the immune response against the Neisseria meningitidis serogroup B subfamily B strain. 4. The method according to claim 1, wherein the immune response against the Neisseria meningitidis serogroup B subfamily A strain in the human comprises a bactericidal titer that is greater than the bactericidal titer against the Neisseria meningitidis serogroup B subfamily B strain in the human. 5. The method according to claim 1, wherein the composition induces a bactericidal immune response against any one of N. meningitidis serogroup B A22, A56, B24, B44 strains, or any combination thereof. 6. The method according to claim 1, wherein the composition induces a bactericidal immune response against any one of N. meningitidis serogroup B B24, B16, B44, A22, B03, B09, A12, A19, A05, A07, B153 strains, or any combination thereof. 7. A method of inducing a bactericidal immune response against a Neisseria meningitidis serogroup B strain expressing B153 factor H binding protein in a human, comprising administering to the human an effective amount of a composition, said composition comprising a) a first lipidated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1, andb) a second lipidated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 2. 8. The method according to claim 7, wherein the composition further comprises polysorbate-80, aluminum, histidine, and sodium chloride.
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