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Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
  • A61K-038/17
  • C07K-016/28
  • C07K-016/24
  • A61K-035/13
  • A61K-039/00
  • A61K-045/06
출원번호 US-0697007 (2015-04-27)
등록번호 US-9839670 (2017-12-12)
발명자 / 주소
  • Podack, Eckhard R.
  • Deyev, Vadim
  • Levy, Robert
출원인 / 주소
  • UNIVERSITY OF MIAMI
대리인 / 주소
    Morgan, Lewis & Bockius LLP
인용정보 피인용 횟수 : 0  인용 특허 : 59

초록

This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e.g., to treat

대표청구항

1. A tumor vaccine comprising a tumor antigen and a TNFR25 agonist, wherein said TNFR25 agonist is selected from the group consisting of: (a) an antibody that binds to TNFR25, wherein said antibody is capable of increasing OT-I CD8 cell expansion when cross-primed by gp96-Ig-ovalbumin relative to a

이 특허에 인용된 특허 (59)

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