System for extended storage of red blood cells and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-019/00
B01D-053/22
A61M-001/02
A01N-001/02
출원번호
US-0924179
(2015-10-27)
등록번호
US-9844615
(2017-12-19)
발명자
/ 주소
Yoshida, Tatsuro
Vernucci, Paul
출원인 / 주소
New Health Sciences, Inc.
대리인 / 주소
Arnold & Porter Kaye Scholer LLP
인용정보
피인용 횟수 :
0인용 특허 :
173
초록▼
A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended sto
A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
대표청구항▼
1. A method for preparing whole blood for transfusion comprising: obtaining whole blood;depleting oxygen and carbon dioxide from said whole blood prior to storage to prepare oxygen and carbon dioxide depleted whole blood;storing said oxygen and carbon dioxide depleted whole blood in a anaerobic stor
1. A method for preparing whole blood for transfusion comprising: obtaining whole blood;depleting oxygen and carbon dioxide from said whole blood prior to storage to prepare oxygen and carbon dioxide depleted whole blood;storing said oxygen and carbon dioxide depleted whole blood in a anaerobic storage bag comprising an outer bag having a barrier film that is impermeable to oxygen and carbon dioxide, an inner bag in contact with said whole blood, and an oxygen and carbon dioxide sorbent disposed between said inner bag and said outer bag. 2. The method of claim 1, further comprising oxygenating said stored oxygen and carbon dioxide depleted whole blood. 3. The method of claim 1, further comprising leukoreducing said whole blood prior to said depleting. 4. The method of claim 1, wherein said inner bag comprises polyvinyl chloride (PVC). 5. The method of claim 4, wherein said inner bag comprises di(2-ethylhexyl) phthalate (DEHP)-plasticized PVC. 6. The method of claim 1, further comprising inactivating pathogens before storage of said oxygen and carbon dioxide depleted whole blood. 7. The method of claim 6, wherein said inactivating pathogens comprises riboflavin and light therapy. 8. The method of claim 1, wherein said depleting oxygen and carbon dioxide comprises passing said whole blood through a combined leukoreduction and oxygen and carbon dioxide depletion device. 9. The method of claim 8, wherein said depleting oxygen and carbon dioxide from said whole blood comprises passing said whole blood through a device having a disposable housing, an inlet port, an outlet port, one or more gas permeable membranes adapted to receiving and conveying whole blood, an oxygen sorbent and a carbon dioxide sorbent to form oxygen and carbon dioxide depleted whole blood. 10. The method of claim 9, wherein said oxygen sorbent and said carbon dioxide sorbent of said anaerobic storage bag, of said combined leukoreduction and oxygen and carbon dioxide depletion device, or of said anaerobic storage bag and said combined leukoreduction and oxygen and carbon dioxide depletion device, are a combined oxygen and carbon dioxide sorbent. 11. The method of claim 1, further comprising adding an additive solution to said whole blood to form a suspension of whole blood. 12. The method of claim 11, wherein said additive solution comprises AS-1, AS-3, AS-5, SAGM, PAGG-SM, PAGG-GM, MAP, SOLX, ESOL, EAS61, OFAS1, OFAS3, or any combinations thereof. 13. The method of claim 1, wherein said anaerobic storage bag having depleted whole blood is stored under refrigeration. 14. The method of claim 13, wherein said storage temperature is from 1 to 6° C. 15. The method of claim 1, further comprising one or more steps selected from the group consisting of: irradiating said whole blood or said oxygen and carbon dioxide depleted whole blood;inactivating pathogens in said whole blood or said oxygen and carbon dioxide depleted whole blood; andediting said whole blood or said oxygen and carbon dioxide depleted whole blood. 16. A kit for the collection and storage of whole blood comprising a phlebotomy needle;a collection bag having an anticoagulant solution;a depletion device comprising a housing, a plurality of membranes permeable to both oxygen and carbon dioxide and are adapted to receiving and conveying whole blood extending within the housing from an entrance to an exit thereof;an amount of both an oxygen sorbent and carbon dioxide sorbent packed within the housing and contiguous to said plurality of membranes; anda storage bag comprising an outer bag having a barrier film, an inner bag in contact with said whole blood, and a sorbent disposed between said inner bag and said outer bag. 17. The kit of claim 16, further comprising a leukoreduction device. 18. The kit of claim 17, wherein said leukoreduction device is a combined leukoreduction and depletion device.
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