최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0554992 (2014-11-26) |
등록번호 | US-9861296 (2018-01-09) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 3 인용 특허 : 417 |
An improved device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to deliver one or more therapeutic agents. In one embodiment, the probe communicates wirelessly with a portable electronic device outside the organism in order to re
An improved device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to deliver one or more therapeutic agents. In one embodiment, the probe communicates wirelessly with a portable electronic device outside the organism in order to receive commands to deliver the therapeutic agent, or perform other functions while the probe is within the intestinal tract.
1. An electronic probe ingestible by a human being, the electronic probe comprising: a housing;a digital processor apparatus disposed within the housing;an electrical power source configured to provide electrical power to at least the digital processor apparatus;a reservoir at least partly disposed
1. An electronic probe ingestible by a human being, the electronic probe comprising: a housing;a digital processor apparatus disposed within the housing;an electrical power source configured to provide electrical power to at least the digital processor apparatus;a reservoir at least partly disposed within the housing and capable of storage of an agent; anda release apparatus in data communication with the digital processor apparatus and configured to selectively release at least a portion of the agent to a region exterior to the housing at a target location within an intestinal tract of the human being;wherein the digital processor apparatus is configured to: automatically enter a sleep state after ingestion by the human being, the sleep state reducing electrical power consumption by at least the digital processor apparatus for at least a portion of time that the probe is moving through the intestinal tract of the human being as compared to a normal operating state of the digital processor apparatus; andexit the sleep state prior to arrival of the probe at the target location within the intestinal tract of the human being and the selective release of the at least portion of the agent. 2. The probe of claim 1, further comprising a first wireless interface in data communication with the digital processor apparatus and configured to at least receive a wireless data command issued by an apparatus external to the human being while the probe is disposed within an intestinal tract of the human being. 3. The probe of claim 2, wherein the first wireless interface comprises a short range inductive wireless interface. 4. The probe of claim 3, wherein the short range inductive wireless interface comprises a passive radio frequency apparatus configured to backscatter energy incident thereon. 5. The probe of claim 4, wherein the apparatus external to the human being comprises a portable personal device configured to be carried by the human being, and further configured to emit an interrogation signal to cause said backscatter. 6. The probe of claim 2, wherein the apparatus external to the human being comprises a portable personal device configured to be carried by the human being, and further configured to emit said wireless command, the wireless command comprising a command to cause said probe to perform said selective release of said agent. 7. The probe of claim 1, wherein the probe further comprises a storage device in data communication with the digital processor apparatus, the storage device comprising at least one computer program configured to, when executed on the digital processor apparatus, cause the selective release. 8. The probe of claim 7, wherein the causation of the selective release comprises causation of the selective release when a prescribed criterion is met. 9. The probe of claim 8, wherein the prescribed criterion comprises the probe reaching a desired location within an intestinal tract of the human being. 10. The probe of claim 1, further comprising: a wireless interface in data communication with the digital processor apparatus;a data storage device in data communication with the digital processor apparatus; andcomputerized logic configured to enable user-specific data to be received from an external transmitter via the wireless interface and stored in the storage device while the probe is in situ. 11. The probe of claim 1, wherein the release apparatus utilizes at least an electrical current generated from energy stored in said electrical power source to initiate the selective release. 12. The probe of claim 11, further comprising an orifice apparatus configured to regulate at least a portion of said release of said agent according to a desired rate or limit. 13. The probe of claim 1, further comprising orifice apparatus configured to regulate at least a portion of said release of said agent according to a desired rate or limit. 14. The probe of claim 1, further comprising an accelerometer, and wherein the digital processor apparatus is configured to exit the sleep state prior to the selective release based at least in part on a signal originated by the accelerometer indicating movement of the human being. 15. The probe of claim 1, further comprising a first wireless interface in data communication with the digital processor apparatus and configured to at least receive a wireless data command issued by an apparatus external to the human being while the probe is disposed within an intestinal tract of the human being, the wireless command configured to cause at least said exit of the state. 16. The probe of claim 1, further comprising a second reservoir configured to contain a second agent, and wherein the probe is configured to, based at least on a signal from the digital processor apparatus, selectively cause mixing of the agent and the second agent while the probe is in situ. 17. The probe of claim 1, wherein the agent comprises at least one of a ligand and/or gene therapy agent. 18. An electronic probe ingestible by a human being and configured to deliver at least one therapeutic agent to the interior of the intestinal tract of the human being, the electronic probe comprising: a housing sized so that it may be swallowed by the human being;a digital processor apparatus disposed within the housing;a first wireless interface disposed at least partly within the housing and in data communication with the digital processor apparatus;a reservoir at least partly disposed within the housing and capable of storage of the at least one therapeutic agent, the reservoir comprising at least one aperture communicating with a region exterior to the housing, the at least one aperture being disposed in a recessed portion of an outer surface of the housing;a first dislocatable element configured to obstruct the at least one aperture prior to expulsion of the therapeutic agent; anda pressurization apparatus controlled by the digital processor apparatus and configured to selectively cause dislocation of the first dislocatable element and expulsion of at least a portion of the at least one therapeutic agent in the reservoir to the region exterior to the housing when the probe is within the intestinal tract, the region exterior being within the intestinal tract, such that the released at least portion of the at least one therapeutic agent is directly applied to at least part of the intestinal tract. 19. An electronic probe ingestible by a human being and configured to deliver at least one therapeutic agent targeted to the interior portion of the intestinal tract of the human being, the interior portion comprising a portion after a stomach of the intestinal tract, the electronic probe comprising: a housing sized so that it may be swallowed by the human being;a digital processor apparatus disposed within the housing;a first wireless interface disposed at least partly within the housing and in data communication with the digital processor apparatus;a reservoir at least partly disposed within the housing and capable of storage of the at least one therapeutic agent; andan apparatus controlled by the digital processor apparatus and configured to, upon receipt of a data command via the first wireless interface, selectively cause pressurization of at least a portion of the therapeutic agent in the reservoir via direct application of a pressurized substance on the at least portion of the therapeutic agent so as to cause expulsion of the at least portion of the at least one therapeutic agent to a region exterior to the housing when the probe is within the intestinal tract, the region exterior being within the portion of the intestinal tract, such that the released at least portion of the at least one therapeutic agent is directly applied to the portion of the intestinal tract;wherein the reservoir is configured to remain sealed until at least the receipt of the command. 20. The probe of claim 18, wherein the probe is configured such that the dislocation of the dislocatable element occurs based on a differential pressure between said reservoir and said region exterior to said housing. 21. The probe of claim 18, wherein the probe is configured such that the dislocation of the dislocatable element is enabled at least in part by one or more mechanical features of said dislocatable element, said one or more mechanical features comprising one or more selectively weakened portions of said dislocatable element causing at least a portion of said dislocatable element to rupture upon application of a differential pressure. 22. An electronic probe ingestible by a human being for passage through an intestinal tract of the human being and internal delivery of an agent to the human being, the electronic probe comprising: a housing;a digital processor apparatus disposed within the housing;a passive wireless apparatus configured to at least generate electrical power when radio frequency energy is incident thereon;a reservoir at least partly disposed within the housing and capable of storage of the agent; anda release apparatus in data communication with the digital processor apparatus and configured to selectively release at least a portion of the agent to a region exterior to the housing and expose at least a portion of the intestinal tract to the at least portion of the agent;wherein the digital processor is configured to awake from a completely shut down state during passage of the probe through the intestinal tract prior to the selective release, the selective release based at least on receipt of electrical power from said passive wireless apparatus, and subsequently issue one or more data commands to cause said selective release. 23. The probe of claim 22, wherein the passive wireless apparatus is configured to backscatter at least a portion of said radio frequency energy, said backscattered at least portion modulated so as to encode data therein, the encoded data descriptive of at least one of (i) the probe; and/or (ii) the human being. 24. The probe of claim 22, wherein the wherein the electronic probe comprises no battery or electrical power source other than said passive wireless apparatus. 25. An electronic probe ingestible by a human being and configured to deliver at least one therapeutic agent targeted to the interior portion of the intestinal tract of the human being, the interior portion comprising a portion after a stomach of the intestinal tract, the electronic probe comprising: a housing sized so that it may be swallowed by the human being;a digital processor apparatus disposed within the housing;a reservoir at least partly disposed within the housing and capable of storage of the at least one therapeutic agent; andan apparatus controlled by the digital processor apparatus and configured to, upon receipt of a data command issued from the digital processor apparatus, selectively cause expulsion of at least a portion of the at least one therapeutic agent from the reservoir to a region exterior to the housing when the probe is within the portion of the intestinal tract, the selective expulsion comprising expulsion of the at least portion of the at least one therapeutic agent through at least one aperture of the reservoir, the at least one aperture disposed at oblique angle relative to an outer surface of the housing, such that the released at least portion of the at least one therapeutic agent is directly applied to the portion of the intestinal tract;wherein the reservoir is configured to remain sealed until at least said causation of said expulsion by the digital processor apparatus. 26. The probe of claim 18, wherein the recessed portion of the outer surface of the housing is configured to position the at least one aperture at an oblique angle relative to an interior surface of the at least part of the intestinal tract. 27. The probe of claim 20, wherein the pressurization apparatus comprises an aperture communicating with the reservoir, a second dislocatable element configured to obstruct the aperture of the pressurization apparatus prior to receipt of a data command via the first wireless interface, the data command comprising data indicative of a command to activate the pressurization apparatus. 28. The probe of claim 27, wherein the pressurization apparatus is further configured to, upon receipt of the data command via the first wireless interface, selectively cause dislocation of the second dislocatable element prior to the expulsion of the at least portion of the therapeutic agent. 29. The probe of claim 28, wherein the probe is configured such that the dislocation of the second dislocatable element is enabled at least in part by one or more mechanical features of the second dislocatable element, the one or more mechanical features comprising one or more selectively weakened portions of the second dislocatable element configured to cause at least a portion of the second dislocatable element to rupture. 30. The probe of claim 19, wherein the pressurized substance comprises a non-toxic gas. 31. The probe of claim 19, wherein the probe is configured to transiently expel at least a portion of the pressurized substance during the expulsion of the at least portion of the therapeutic agent. 32. The probe of claim 25, wherein the reservoir comprises at least one aperture communicating with the region exterior of the housing, the at least one aperture disposed at an oblique angle relative to an outer surface of housing and configured to enable the expulsion of the of the at least portion of the at least one therapeutic agent from the reservoir to the region exterior to the housing at the oblique angle relative to the portion of the intestinal wall. 33. The probe of claim 32, wherein the at least one aperture is disposed within a recessed portion of an outer surface of the housing. 34. An electronic probe ingestible by a human being, the electronic probe comprising: a housing;a digital processor apparatus disposed within the housing;an electrical power source configured to provide electrical power to at least the digital processor apparatus;a reservoir at least partly disposed within the housing and capable of storage of an agent;a release apparatus in data communication with the digital processor apparatus and configured to selectively release at least a portion of the agent to a region exterior to the housing at a target location within an intestinal tract of the human being; anda first wireless interface in data communication with the digital processor apparatus and configured to at least receive a wireless data command issued by an apparatus external to the human being while the probe is disposed within an intestinal tract of the human being, the apparatus external to the human being comprising a portable personal device configured to be carried by the human being, and further configured to emit said wireless command, the wireless command comprising a command to cause said probe to perform said selective release of said agent;wherein the digital processor apparatus is configured to: enter a reduced operational state after ingestion by the human being, the reduced operational state comprising a reduction of electrical power consumption by the digital processor apparatus over a normal operating state of the digital processor apparatus, for at least a portion of time that the probe is moving through the intestinal tract of the human being; andexit the reduced operational state at or prior to arrival of the probe at the target location within the intestinal tract of the human being, and prior to the selective release of the at least portion of the agent.
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