Methods for reducing body fat using tafluprost and analogs thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07C-059/46
A61K-031/5575
A61K-009/00
A61K-009/06
A61K-008/69
A61Q-019/06
A61Q-019/00
A61K-031/165
A61K-031/191
A61K-031/216
A61K-031/25
출원번호
US-0932445
(2015-11-04)
등록번호
US-9861641
(2018-01-09)
발명자
/ 주소
Kalayoglu, Murat V.
Singer, Michael S.
출원인 / 주소
Topokine Therapeutics, Inc.
대리인 / 주소
Wolf, Greenfield & Sacks, P.C.
인용정보
피인용 횟수 :
1인용 특허 :
66
초록▼
Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug th
Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR1, —SR2, or —NR3R4, and R1, R2, R3, R4, R5, R6, R7, R7′, Z, Y, n, y, and x, are as defined herein.
대표청구항▼
1. A method for reducing body fat in a subject having an excess deposit of body fat, comprising administering to the skin of the subject a compound of the Formula (II): or a pharmaceutically acceptable salt or stereoisomer thereof,wherein R1 is hydrogen or C1-C6 alkyl. 2. The method of claim 1, wher
1. A method for reducing body fat in a subject having an excess deposit of body fat, comprising administering to the skin of the subject a compound of the Formula (II): or a pharmaceutically acceptable salt or stereoisomer thereof,wherein R1 is hydrogen or C1-C6 alkyl. 2. The method of claim 1, wherein R1 is hydrogen. 3. The method of claim 1, wherein R1 is C1-C4 alkyl. 4. The method of claim 1, wherein R1 is methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, isobutyl, or sec-butyl. 5. The method of claim 1, wherein R1 is ethyl. 6. The method of claim 1, wherein R1 is isopropyl. 7. The method of claim 1, wherein the subject suffers from obesity. 8. The method of claim 1, wherein the subject suffers from gynecomastia. 9. The method of claim 1, wherein the subject suffers from lipoma. 10. The method of claim 1, wherein the subject suffers from excess fat on the chin. 11. The method of claim 1, wherein the subject suffers from orbital fat prolapse. 12. The method of claim 1, wherein the compound is administered topically. 13. The method of claim 1, wherein the compound is administered subcutaneously, intradermally, or intralesionally. 14. The method of claim 1, wherein the skin is facial skin. 15. The method of claim 1, wherein the skin is palpebral skin. 16. The method of claim 1, wherein the compound is provided in a pharmaceutical composition, and further wherein the concentration of the compound in the pharmaceutical composition is between 0.001% and 1% w/w, inclusive. 17. The method of claim 16, wherein the concentration of the compound in the pharmaceutical composition is between 0.01% and 1% w/w, inclusive. 18. The method of claim 16, wherein the pharmaceutical composition is an ointment. 19. The method of claim 16, wherein the pharmaceutical composition is sterile. 20. The method of claim 16, wherein the pharmaceutical composition comprises isopropyl myristate.
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