Amine-functionalized polymeric compositions for medical devices
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-026/00
A61L-015/26
A61F-013/00
C08J-009/36
C08G-018/84
C08G-018/83
C08G-018/08
C08G-018/32
C08G-018/76
C08J-009/00
출원번호
US-0491228
(2017-04-19)
등록번호
US-9861723
(2018-01-09)
발명자
/ 주소
Hanson, Douglas Philip
Courage, James
출원인 / 주소
KCI Licensing, Inc.
대리인 / 주소
Harness, Dickey & Pierce, P.L.C.
인용정보
피인용 횟수 :
0인용 특허 :
90
초록▼
The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active pol
The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.
대표청구항▼
1. A wound dressing comprising an amine-functionalized polymer foam and a biologically active agent covalently attached to an amine group on the polymer foam. 2. The wound dressing of claim 1, wherein the biologically active agent is attached to the foam through an adapter. 3. The wound dressing of
1. A wound dressing comprising an amine-functionalized polymer foam and a biologically active agent covalently attached to an amine group on the polymer foam. 2. The wound dressing of claim 1, wherein the biologically active agent is attached to the foam through an adapter. 3. The wound dressing of claim 1, wherein the biologically active agent is a polypeptide. 4. The wound dressing of claim 3, wherein the polypeptide is selected from the group consisting of gelatin, collagen, albumin, an enzyme, growth factor, chemokine, cytokine, and a polypeptide that binds to any of them. 5. The wound dressing of claim 4, wherein the polypeptide is an enzyme selected from a protease, hydrolase, lyase, ligase, isomerase, transferase, oxidase, reductase, oxidoreductase, synthase, polymerase, kinase, and phosphatase. 6. The wound dressing of claim 1, comprising a polyurethane foam. 7. The wound dressing of claim 6, comprising an open cell foam. 8. The wound dressing of claim 1, wherein the amine-functionalized polymer foam comprises a polyurethane polymer copolymerized with neomycin. 9. The wound dressing of claim 1, wherein the biologically active agent is directly attached to the functionalized polymer foam. 10. The wound dressing of claim 2, wherein the adapter is an amine to amine crosslinker. 11. The wound dressing of claim 10, wherein the amine-to-amine crosslinker is selected from malondialdehyde, succinaldehyde, phthalaldehyde, glutaraldehyde, and glyoxal. 12. The wound dressing of claim 11, wherein the crosslinker is glutaraldehyde. 13. The wound dressing of claim 2, wherein the adapter is cleavable. 14. The wound dressing of claim 7, wherein the material comprises a foam that is a reticulated open-celled foam. 15. A method for treating a wound site, comprising: applying a wound dressing according to claim 1 to a wound site; andapplying negative pressure to the wound site. 16. The method of claim 15, further comprising applying an instillation solution to the wound site. 17. The method of claim 15, wherein the biologically active agent comprises a polypeptide. 18. The method of claim 16, wherein the instillation solution includes one or more agents that modulate a release of the biologically active agent. 19. The wound dressing of claim 1, wherein the biologically active agent comprises a debridement enzyme. 20. The wound dressing according to claim 19, wherein the biologically active agent is bromelain. 21. The wound dressing according to claim 19, wherein the biologically active agent is papain. 22. The wound dressing according to claim 19, wherein the biologically active agent is trypsin. 23. The wound dressing according to claim 19, wherein the biologically active agent is collagenase.
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이 특허에 인용된 특허 (90)
Ward William J. (Hull GBX) Shorthouse Joanne (Hull GBX), Adhesive dressing for retaining a cannula on the skin.
Errede Louis A. (North Oaks MN) Stoesz James D. (St. Paul MN) Winter ; deceased George D. (late of St. Paul MN by Jenny Upton ; personal representative), Composite wound dressing.
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Moriuchi Yousuke (Fujinomiya JPX) Ishida Toshinobu (Fujinomiya JPX) Kousai Tadashi (Fujinomiya JPX), Method of securing a catheter body to a human skin surface.
Luheshi Abdul B. N. (Hull GB3) Smalley Robert K. (Urmston GB3) Kennewell Peter D. (Okus GB3) Westwood Robert (Kingston Bagpuize GB3), Process for the preparation of azabicyclo compounds.
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