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Hydrophobically tagged janus kinase inhibitors and uses thereof

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07D-239/48
  • C07D-401/14
  • C07D-403/12
  • C07D-487/04
출원번호 US-0305845 (2015-04-23)
등록번호 US-9862688 (2018-01-09)
국제출원번호 PCT/US2015/027294 (2015-04-23)
국제공개번호 WO2015/164604 (2015-10-29)
발명자 / 주소
  • Gray, Nathanael S.
  • Tan, Li
출원인 / 주소
  • Dana-Farber Cancer Institute, Inc.
대리인 / 주소
    Wolf, Greenfield & Sacks, P.C.
인용정보 피인용 횟수 : 3  인용 특허 : 60

초록

The present invention provides Janus kinase inhibitors, such as compounds of Formula (I) and Formula (II) wherein RY1 and RY2 comprise a tagged hydrophobic moiety RH. The compounds may covalently or non-covalently bind a kinase (e.g., Janus kinase 3 (JAK3)). The hydrophobic moiety RH may signal to t

대표청구항

1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: W1 is N, W2 is N and W3 is CRX, or W1 is N, W2 is CH, and W3 is N;RY1 is a group of formula or L1-RH; L3 is a bond or a linker selected from the group consisting of substituted and unsubstituted C1-6alkylene, sub

이 특허에 인용된 특허 (60)

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이 특허를 인용한 특허 (3)

  1. Gray, Nathanael; Zhang, Tinghu, Inhibitors of c-Jun-N-terminal kinase (JNK).
  2. Gray, Nathanael; Zhang, Tinghu; Kwiatkowski, Nicholas Paul, Inhibitors of cyclin-dependent kinase 7 (CDK7).
  3. Gray, Nathanael S.; Tan, Li, Janus kinase inhibitors and uses thereof.
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