[특허]Spray-dried blood products and methods of making same

Spray-dried blood products and methods of making same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/16 A61F-013/00 A61K-009/00 A61K-035/16 A61K-035/19 A61L-026/00
출원번호	US-0262931 (2010-04-06)
등록번호	US-9867782 (2018-01-16)
국제출원번호	PCT/US2010/030031 (2010-04-06)
§371/§102 date	20111013 (20111013)
국제공개번호	WO2010/117976 (2010-10-14)
발명자 / 주소	Fischer, Thomas H. DaCorta, Joseph A. Galiger, Michael Lawrence
출원인 / 주소	ENTEGRION, INC.
대리인 / 주소	NexSen Pruet, PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 44

초록 ▼

The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method. The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient. The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.

대표청구항 ▼

1. A method of preparing dehydrated plasma, comprising the steps of: a. providing hydrated plasma having a first level of activities of clotting factors;b. measuring said first level of activities of clotting factors;c. spray-drying said hydrated plasma at a temperature between about 110° C. to about 140° C. to produce dehydrated plasma, wherein said activities of clotting factors are preserved;d. measuring a second level of activities of said clotting factors after said spray-drying; ande. rehydrating said dehydrated plasma comprising said second level of activities of clotting factors that are essentially the same as said first level of clotting factors. 2. The method of claim 1, wherein said hydrated plasma is physically or chemically modified. 3. The method of claim 2, wherein said modification is chemical fixation. 4. The method of claim 2, wherein said modification comprises additional diagnostic or therapeutic reagents. 5. The method of claim 4, wherein said diagnostic or therapeutic reagents are selected from the group consisting of imaging agents, concentration factors, performance enhancement drugs, antimicrobial and antiviral reagents, universal donor solutions, and combinations thereof. 6. A method of preparing dehydrated plasma, comprising the steps of: a. providing hydrated plasma having a first level of activities of clotting factors;b. measuring said first level of activities of clotting factors;c. spray-drying said hydrated plasma at a temperature between 110° C. to 140° C. to produce dehydrated plasma having a second level of activities of clotting factors; andd. measuring said second level of activities of clotting factors after said spray-drying, wherein said activities of clotting factors are preserved after said spray-drying such that said first and second levels of activities of clotting factor levels of said hydrated plasma and of said dehydrated plasma are essentially the same.

이 특허에 인용된 특허 (44)

Yoder Ralph P. (Fort Dodge IA), Animal feed supplement containing co-spray dried plasma protein and amylase.
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Yoder Ralph P. (Fort Dodge IA), Animal feed supplement containing co-sprayed dried plasma protein and amylase.
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Andersen Poul Rasmus (Kvistgrd DKX) Hansen Ove Emil (Allerd DKX), Apparatus and process for drying a moist material dispersed or dispersible in a stream of drying gas.
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Esvan Daniel (Maffliers FRX) Roisin Jean P. (Saint Maur des Fosses FRX), Apparatus for detecting a change of viscosity by measuring a relative slip, in particular for detecting the coagulation.
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Botich Leon A. (10125 E. Tanglewood Cir. Palos Park IL 60464), Apparatus for heating purge gas and transmitting microwave energy for desiccant regeneration.
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Wright,David W.; Kriewall,Timothy J.; Cheek,Daniel S., Blood coagulation test cartridge, system, and method.
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Kisic, Julie A.; Shipp, Thomas E., Combination of plasma and hyperimmunized products for increased performance.
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Bote Bote,Antonio, Device and method for measuring coagulation time and platelet activity.
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Stiene,Matthias; Richter,Tanja; McAleer,Jerome; Plotkin,Elliot; Alvarez Icaza,Manuel; Allen,John, Device for measuring blood coagulation and method thereof.
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Lu, Shun-Tsung; Lu, Ta-Wei, Device for separating dry solid and liquid by cooling spray.
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Doty Brian D. (Phoenixville PA) Meyer Mark (Ames IA), Dried animal plasma as a pharmaceutical excipient for compressed tablet formulation.
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Ware Gerald J. (754 Brookside Ct. Vacaville CA 95688), Drying apparatus and method.
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Kral, Jude A.; Priest, Robert M.; Kelsch, Daniel N.; Hlebovy, James C.; Sanford, Bill R.; Greszler, Alan J.; Zelina, Francis John; Klobusnik, Kenneth J., Fluid spray system for cleaning and sterilizing medical devices supported on a rack.
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Weaver Eric M. ; Campbell Joy M. ; Russell Louis, Granular plasma protein supplement with increased bio-efficacy.
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Tankersley Donald L. (Rockville MD), Intravenously injectable solution of plasma protein fraction free from bradykinin, kininogen and prekallikrein activator.
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Tankersley, Donald L., Intravenously injectable solution of plasma protein fraction free from bradykinin, kininogen and prekallikrein activators and processes for its production.
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Herbert,Paul F.; Bissonnette,Douglas M.; Troiano,Gregory C., Method and apparatus for filtering and drying a product.
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Jina Arvind N., Method and device for measuring blood coagulation or lysis by viscosity changes.
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Fischer,Timothy J.; Baglin,Trevor; Tejidor,Liliana, Method for assessing coagulation.
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Guy Feuilloley FR; Veronique Bernard FR, Method for drying a hollow body and implementing device.
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Hagi Takashi (Yokkaichi JPX) Misawa Kouichi (Yokohama JPX) Saito Shuji (Fujisawa JPX) Sakamoto Yuji (Yokkaichi JPX) Kadota Noriaki (Mie JPX) Toda Yoshiro (Suzuka JPX) Yamazaki Nagataka (Yokkaichi JPX, Method for preparation of plasma powder and product thereof.
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van Dommelen Frederik S. (Apeldoorn NLX) Roodink Hendrikus B. J. (Twello NLX), Method for purifying blood plasma.
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Suzuki Yoshio (Kamakura JPX) Shimizu Masao (Yokohama JPX), Method for reducing the bacterial population of blood powder.
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Hajek,Milan; Drahos,Jiri, Method of drying book and similar paper-based materials.
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Crenshaw, Joe David; Campbell, Joy; Russell, Louis E., Methods of increasing productivity in older sows while decreasing feed intake.
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Takabatake Hikaru (Yokohama JPX) Shudo Yoshiro (Tokyo JPX), Multipurpose basic apparatus for treating powders.
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Mortazavi Sassan ; Ataee Mehran, PWM/linear driver for disk drive voice coil actuator.
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Read Marjorie S. ; Reddick Robert L. ; Bode Arthur P., Pharmaceutically acceptable fixed-dried human blood platelets.
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Campbell,Joy; Russell,Louis E., Poultry feed containing plasma.
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Wang, Zhaolin; Finlay, Warren H., Powder formation by atmospheric spray-freeze drying.
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Wang,Zhaolin; Finlay,Warren H., Powder formation by atmospheric spray-freeze drying.
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Ove Emil Hansen DK; Jens Mourits S?rensen DK; Martin Andreas Gr?nlund Scholten DK, Process and a plant for spray drying.
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Folan Michael Anthony,IEX, Process for drying a material from solution.
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Meldrum, Charles R., Produce drying system utilizing multiple energy sources.
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Hubbard, Dennis Brian; Haley, Michael, Spray dried human plasma.
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Hubbard, Jr., Dennis Brian; Haley, Michael, Spray dried human plasma.
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Becker ; Jr. James J. (1205 S. 1st St. Stillwater MN 55082) Beresford Henry T. (2243 E. Larpenteur Ave. ; Apt. 115 Maplewood MN 55109), Spray dryer.
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Chickering, III, Donald E.; Keegan, Mark J.; Randall, Greg; Bernstein, Howard; Straub, Julie, Spray drying apparatus and methods of use.
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Chickering ; III Donald E. ; Keegan Mark J. ; Randall Greg ; Bernstein Howard ; Straub Julie, Spray drying method.
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Titus Hans-Joachim (11 ; Av. Princesse Grace MC 98 Monaco MCX), Suction filter-drier.
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Wolkers, Willem F.; Crowe, John H.; Tablin, Fern; Oliver, Ann E.; Walker, Naomi J.; Tsvetkova, Nelly, Therapeutic platelets and methods.
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Bergquist Dwight H. (Omaha NE) Lorimor Gary D. (Omaha NE) Wildy Thomas E. (Omaha NE), Tower spray dryer with hot and cool air supply.
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Iijima Tetsuo,JPX, Two-fluid nozzle and device employing the same nozzle for freezing and drying liquid containing biological substances.
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Takahashi Masashi,JPX, Two-stage drying spray dryer.
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